| Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD transformation. | Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation.
Wang L, Zha H, Huang J, Shi L., Free PMC Article | 11/1/2023 |
| Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-beta/Smad3 Signaling. | Smurf2 Regulates Inflammation and Collagen Processing in Cutaneous Wound Healing through Transforming Growth Factor-β/Smad3 Signaling.
Stuelten CH, Melis N, Subramanian B, Tang Y, Kimicata M, Fisher JP, Weigert R, Zhang YE., Free PMC Article | 12/10/2022 |
| Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells. | Inhibition of ChREBP ubiquitination via the ROS/Akt-dependent downregulation of Smurf2 contributes to lysophosphatidic acid-induced fibrosis in renal mesangial cells.
Kim D, Nam GY, Seo E, Jun HS., Free PMC Article | 05/14/2022 |
| MicroRNA-411-3p inhibits bleomycin-induced skin fibrosis by regulating transforming growth factor-beta/Smad ubiquitin regulatory factor-2 signalling. | MicroRNA-411-3p inhibits bleomycin-induced skin fibrosis by regulating transforming growth factor-β/Smad ubiquitin regulatory factor-2 signalling.
Zhang Z, Gao X, He Y, Kang Y, Jin F, Li Y, Li T, Wei Z, Li S, Cai W, Mao N, Wang S, Liu H, Yang F, Xu H, Yang J., Free PMC Article | 03/26/2022 |
| Smurf2 exerts neuroprotective effects on cerebral ischemic injury. | Smurf2 exerts neuroprotective effects on cerebral ischemic injury.
Liu H, Sun S, Liu B., Free PMC Article | 12/4/2021 |
| The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice. | The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice.
Mosayebzadeh Roshan H, Abtahi-Eivary SH, Shojaee-Mend H, Mohammadzadeh A, Bahari Sani Z., Free PMC Article | 02/6/2021 |
| Smurf2 negatively regulates MOR1 activity by reducing its stability in lung epithelial cells. | The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells.
Dong S, Liu J, Li L, Wang H, Ma H, Zhao Y, Zhao J., Free PMC Article | 02/15/2020 |
| although conventional Smurf2 double knockout mice are early embryonic lethal, Cre-mediated recombination in mouse embryonic fibroblasts results in Smurf2 knockout cells that show it has roles in regulating many different signaling pathways and in genomic stability, cell polarity, tissue homeostasis and carcinogenesis | Generation of Smurf2 Conditional Knockout Mice.
Tang Y, Tang LY, Xu X, Li C, Deng C, Zhang YE., Free PMC Article | 07/20/2019 |
| Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex. | SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts.
Xu Z, Greenblatt MB, Yan G, Feng H, Sun J, Lotinun S, Brady N, Baron R, Glimcher LH, Zou W., Free PMC Article | 12/1/2018 |
| Results identified Smurf2 as an essential regulator of Topo IIalpha, providing novel insights into its control and into the suggested tumor-suppressor functions of Smurf2. | Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity.
Emanuelli A, Borroni AP, Apel-Sarid L, Shah PA, Ayyathan DM, Koganti P, Levy-Cohen G, Blank M. | 09/30/2017 |
| Young Smurf2-deficient mice develop milder osteoarthritis in knee articular cartilage compared to WT mice after surgical destabilization of the medial meniscus. | Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.
Huang H, Veien ES, Zhang H, Ayers DC, Song J., Free PMC Article | 07/30/2016 |
| TAT fused to WW2/WW3 of Smurf2 could interfere with TGF-beta signaling and reduce ArgI gene expression. | The effects of WW2/WW3 domains of Smurf2 molecule on TGF-β signaling and arginase I gene expression.
Ganji A, Roshan HM, Varasteh A, Moghadam M, Sankian M. | 02/13/2016 |
| Smurf-mediated endocytosis of Patched1 is required in sonic hedgehog signal reception | Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.
Yue S, Tang LY, Tang Y, Tang Y, Shen QH, Ding J, Chen Y, Zhang Z, Yu TT, Zhang YE, Cheng SY., Free PMC Article | 08/1/2015 |
| Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2). | TRAF4-SMURF2-mediated DAZAP2 degradation is critical for IL-25 signaling and allergic airway inflammation.
Zepp JA, Wu L, Qian W, Ouyang W, Aronica M, Erzurum S, Li X., Free PMC Article | 06/20/2015 |
| Expression of Smurf2 was increased with age and in response to regenerative stress during serial transplantation, our findings suggest that Smurf2 plays an important role in regulating HSC self-renewal and aging. | Smurf2 regulates hematopoietic stem cell self-renewal and aging.
Ramkumar C, Kong Y, Trabucco SE, Gerstein RM, Zhang H., Free PMC Article | 04/4/2015 |
| Akt regulates osteoblast differentiation by enhancing the protein stability and transcriptional activity of Runx2 through regulation of degradation of Smurf2. | Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation.
Choi YH, Kim YJ, Jeong HM, Jin YH, Yeo CY, Lee KY. | 10/18/2014 |
| that Smurf2 is an important nonredundant negative regulator of virus-triggered type I IFN signaling by targeting VISA for K48-linked ubiquitination and degradation. | Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation.
Pan Y, Li R, Meng JL, Mao HT, Zhang Y, Zhang J. | 06/28/2014 |
| Smurf2 mediates ubiquitination and degradation of YY1, a key germinal centre transcription factor. | Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
Ramkumar C, Cui H, Kong Y, Jones SN, Gerstein RM, Zhang H., Free PMC Article | 05/3/2014 |
| Smurf2 deficiency increased the susceptibility of mice to spontaneous tumorigenesis, most notably B-cell lymphoma | Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Ramkumar C, Kong Y, Cui H, Hao S, Jones SN, Gerstein RM, Zhang H., Free PMC Article | 08/11/2012 |
| T cell-specific DeltaE2Smurf2 degrades wild-type Smurf2 and controls intestinal tumor growth in mice by up-regulating TGF-beta receptor type II, reducing proliferation and production of proinflammatory cytokines. | A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.
Dornhoff H, Becker C, Wirtz S, Strand D, Tenzer S, Rosfa S, Neufert C, Mudter J, Markl J, Siebler J, Neurath MF. | 06/23/2012 |
| Smurf2 induces multiple mono-ubiquitination of Smad3 in vivo. Phosphorylation of T179, immediately upstream of the Smad3 PY motif, enhances Smurf2 and Smad3 interaction and Smad3 ubiquitination. | Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3.
Tang LY, Yamashita M, Coussens NP, Tang Y, Wang X, Li C, Deng CX, Cheng SY, Zhang YE., Free PMC Article | 02/25/2012 |
| E3 ubiquitin-protein ligase constitutive photomorphogenesis protein 1 is needed for COP1 for degradation via the ubiquitin-proteasome pathway. | E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.
Li DQ, Ohshiro K, Reddy SD, Pakala SB, Lee MH, Zhang Y, Rayala SK, Kumar R., Free PMC Article | 01/21/2010 |
| Mice mutant for Smurf1 and Smurf2 display planar cell polarity defects in the cochlea and convergence and extension movements defects that include a failure to close the neural tube. | Regulation of planar cell polarity by Smurf ubiquitin ligases.
Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. | 01/21/2010 |
| Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation. | Rheb and mTOR regulate neuronal polarity through Rap1B.
Li YH, Werner H, Püschel AW., Free PMC Article | 01/21/2010 |
| Smurf2-transgenic mice spontaneously develop an osteoarthritis-like phenotype that correlates with decreased TGFbeta signaling and increased pSmad3 degradation | Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.
Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN., Free PMC Article | 01/21/2010 |