| The U1-70K and SRSF1 interaction is modulated by phosphorylation during the early stages of spliceosome assembly. | The U1-70K and SRSF1 interaction is modulated by phosphorylation during the early stages of spliceosome assembly.
Paul T, Zhang P, Zhang Z, Fargason T, De Silva NIU, Powell E, Ekpenyong E, Jamal S, Yu Y, Prevelige P, Lu R, Zhang J., Free PMC Article | 07/19/2024 |
| Clinical significance of small nuclear ribonucleoprotein U1 subunit 70 in patients with hepatocellular carcinoma. | Clinical significance of small nuclear ribonucleoprotein U1 subunit 70 in patients with hepatocellular carcinoma.
Jiang D, Zhu XL, An Y, Li YR., Free PMC Article | 03/20/2024 |
| Galectin-3-U1 snRNP Complexes Initiate Splicing Activity in U1-Depleted Nuclear Extracts. | Galectin-3-U1 snRNP Complexes Initiate Splicing Activity in U1-Depleted Nuclear Extracts.
Voss PG, Haudek KC, Patterson RJ, Wang JL. | 04/2/2022 |
| A specific gene-splicing alteration in the SNRNP70 gene as a hallmark of an ALS subtype. | A specific gene-splicing alteration in the SNRNP70 gene as a hallmark of an ALS subtype.
Nakaya T. | 03/5/2022 |
| CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly. | CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly.
Aubol BE, Wozniak JM, Fattet L, Gonzalez DJ, Adams JA., Free PMC Article | 11/22/2021 |
| Dissection of FUS domains involved in regulation of SnRNP70 gene expression. | Dissection of FUS domains involved in regulation of SnRNP70 gene expression.
Nakaya T. | 05/22/2021 |
| A potential mechanism underlying U1 snRNP inhibition of the cleavage step of mRNA 3' processing. | A potential mechanism underlying U1 snRNP inhibition of the cleavage step of mRNA 3' processing.
Deng Y, Shi J, Ran Y, Xiang AP, Yao C. | 02/27/2021 |
| Data show that two fragments in the low-complexity (LC) domain of small nuclear ribonucleoprotein U1 subunit 70 (U1-70K) can undergo liquid-liquid phase separation (LLPS). | Low-complexity domain of U1-70K modulates phase separation and aggregation through distinctive basic-acidic motifs.
Xue S, Gong R, He F, Li Y, Wang Y, Tan T, Luo SZ., Free PMC Article | 05/9/2020 |
| Screen using siRNA revealed depletion of U1 snRNP components SNRPA, SNRNP70 or SNRPD2 caused significant cytoplasmic localization of MEG3 reporter transcripts. | Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus.
Azam S, Hou S, Zhu B, Wang W, Hao T, Bu X, Khan M, Lei H., Free PMC Article | 03/21/2020 |
| These results indicate that the galectin-3-U1 snRNP-pre-mRNA ternary complex is a functional E complex and that U1 snRNP is required to assemble galectin-3 onto an active spliceosome | A 10S galectin-3-U1 snRNP complex assembles into active spliceosomes.
Haudek KC, Voss PG, Wang JL, Patterson RJ., Free PMC Article | 06/24/2017 |
| The epitopes of U1-70K autoantibodies have been mapped at single-amino acid resolution. | Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution.
Haddon DJ, Jarrell JA, Diep VK, Wand HE, Price JV, Tangsombatvisit S, Credo GM, Mackey S, Dekker CL, Baechler EC, Liu CL, Varma M, Utz PJ., Free PMC Article | 09/24/2016 |
| The authors propose that Gemin2 is a versatile hub for ribonucleoprotein exchange that functions broadly in RNA metabolism. | A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.
So BR, Wan L, Zhang Z, Li P, Babiash E, Duan J, Younis I, Dreyfuss G., Free PMC Article | 07/30/2016 |
| data lead to a model that FUS functions in coupling transcription to splicing via mediating an interaction between RNAP II and U1 snRNP | FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
Yu Y, Reed R., Free PMC Article | 10/31/2015 |
| The selection of 5'-splice site nucleotides by U1 snRNP is achieved predominantly through basepairing with U1 snRNA whilst U1-C fine-tunes relative affinities of mismatched 5'-splice sites. | Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Kondo Y, Oubridge C, van Roon AM, Nagai K., Free PMC Article | 09/26/2015 |
| methylation of snRNP70 by SETMAR regulates constitutive and/or alternative splicing | A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme.
Carlson SM, Moore KE, Sankaran SM, Reynoird N, Elias JE, Gozani O., Free PMC Article | 08/8/2015 |
| U1-70K interacts with the SMN complex and is required for nuclear gem integrity. | The splicing factor U1-70K interacts with the SMN complex and is required for nuclear gem integrity.
Stejskalová E, Staněk D. | 06/27/2015 |
| Data indicate that small nuclear ribonucleoprotein U1-70K in Alzheimer disease (AD) may directly sequester normal soluble forms of U1-70K into insoluble aggregates. | Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.
Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H, Laur O, Gearing M, Troncoso J, Thambisetty M, Lah JJ, Levey AI, Seyfried NT., Free PMC Article | 04/25/2015 |
| [review] The presence of antibodies against U1snRNP autoantigen is considered the serological hallmark of mixed connective tissue disease (MCTD), which is characterized by overlapping features between at least two systemic autoimmune diseases. | The diagnosis and classification of mixed connective tissue disease.
Tani C, Carli L, Vagnani S, Talarico R, Baldini C, Mosca M, Bombardieri S. | 10/4/2014 |
| These studies identify U1 snRNP pathologic changes in brain of early onset genetic forms of Alzheimer's disease | U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.
Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ., Free PMC Article | 09/13/2014 |
| inhibition of U1 snRNP also leads to regulation of the usage of In3 pA, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes. | The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP.
Luo W, Ji Z, Pan Z, You B, Hoque M, Li W, Gunderson SI, Tian B., Free PMC Article | 01/11/2014 |
| Our results demonstrate unique U1 snRNP pathology and implicate abnormal RNA splicing in Alzheimer's disease pathogenesis. | U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.
Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J, Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J., Free PMC Articles: PMC3799305, PMC3799305 | 12/7/2013 |
| High expression of U1-70K and other U1 small nuclear ribonucleoproteins spliceosome proteins in Alzheimer's disease patients and those with mild cognitive impairment. | U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.
Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J, Bai B, Hales CM, Chen PC, Gozal Y, Dammer EB, Fritz JJ, Wang X, Xia Q, Duong DM, Street C, Cantero G, Cheng D, Jones DR, Wu Z, Li Y, Diner I, Heilman CJ, Rees HD, Wu H, Lin L, Szulwach KE, Gearing M, Mufson EJ, Bennett DA, Montine TJ, Seyfried NT, Wingo TS, Sun YE, Jin P, Hanfelt J, Willcock DM, Levey A, Lah JJ, Peng J., Free PMC Articles: PMC3799305, PMC3799305 | 10/25/2013 |
| Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus. | Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study.
Katsumata Y, Kawaguchi Y, Baba S, Hattori S, Tahara K, Ito K, Iwasaki T, Yamaguchi N, Hattori H, Nagata K, Okamoto Y, Yamanaka H, Hara M. | 06/15/2013 |
| U1-snRNP activates the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in CD14+ human monocytes dependently of anti-U1-snRNP Abs, leading to interleukin (IL)-1beta production. | U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes.
Shin MS, Kang Y, Lee N, Kim SH, Kang KS, Lazova R, Kang I., Free PMC Article | 08/11/2012 |
| data identify some fungal proteins as possible triggers of anti-U1-70 kDa autoimmunity via molecular mimicry. | Potential role of molecular mimicry between human U1-70 kDa and fungal proteins in the development of T-cell mediated anti-U1-70 kDa autoimmunity.
Guarneri F, Guarneri B, Borgia F, Guarneri C. | 02/25/2012 |