| A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes. | A novel subpopulation of monocytes with a strong interferon signature indicated by SIGLEC-1 is present in patients with in recent-onset type 1 diabetes.
Guo M, Guo H, Zhu J, Wang F, Chen J, Wan C, Deng Y, Wang F, Xu L, Chen Y, Li R, Liu S, Zhang L, Wang Y, Zhou J, Li S. | 03/1/2024 |
| CD169 expression on monocytes as a marker for assessing type I interferon status in pediatric inflammatory diseases. | CD169 expression on monocytes as a marker for assessing type I interferon status in pediatric inflammatory diseases.
Sakumura N, Yokoyama T, Usami M, Hosono Y, Inoue N, Matsuda Y, Tasaki Y, Wada T. | 05/1/2023 |
| Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis. | Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis.
Klaas M, Dubock S, Ferguson DJP, Crocker PR., Free PMC Article | 03/23/2023 |
| The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease. | The role of sialic acid-binding immunoglobulin-like-lectin-1 (siglec-1) in immunology and infectious disease.
Prenzler S, Rudrawar S, Waespy M, Kelm S, Anoopkumar-Dukie S, Haselhorst T. | 02/22/2023 |
| CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses. | CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.
Jalloh S, Olejnik J, Berrigan J, Nisa A, Suder EL, Akiyama H, Lei M, Ramaswamy S, Tyagi S, Bushkin Y, Mühlberger E, Gummuluru S., Free PMC Article | 11/12/2022 |
| The role of activated monocyte IFN/SIGLEC1 signalling in Graves' disease. | The role of activated monocyte IFN/SIGLEC1 signalling in Graves' disease.
Wang Y, Jin Z, Sun J, Chen X, Xie P, Zhou Y, Wang S. | 09/17/2022 |
| SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies. | SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies.
Graf M, von Stuckrad SL, Uruha A, Klotsche J, Zorn-Pauly L, Unterwalder N, Buttgereit T, Krusche M, Meisel C, Burmester GR, Hiepe F, Biesen R, Kallinich T, Stenzel W, Schneider U, Rose T., Free PMC Article | 07/9/2022 |
| Siglec-1 expression on monocytes is associated with the interferon signature in juvenile dermatomyositis and can predict treatment response. | Siglec-1 expression on monocytes is associated with the interferon signature in juvenile dermatomyositis and can predict treatment response.
Lerkvaleekul B, Veldkamp SR, van der Wal MM, Schatorjé EJH, Kamphuis SSM, van den Berg JM, Hissink Muller PCE, Armbrust W, Vastert SJ, Wienke J, Jansen MHA, van Royen-Kerkhof A, van Wijk F., Free PMC Article | 05/14/2022 |
| Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis. | Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis.
Kong W, Wei M, Liu R, Zhang J, Wang X., Free PMC Article | 02/19/2022 |
| Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles. | Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
Benet S, Gálvez C, Drobniewski F, Kontsevaya I, Arias L, Monguió-Tortajada M, Erkizia I, Urrea V, Ong RY, Luquin M, Dupont M, Chojnacki J, Dalmau J, Cardona P, Neyrolles O, Lugo-Villarino G, Vérollet C, Julián E, Furrer H, Günthard HF, Crocker PR, Tapia G, Borràs FE, Fellay J, McLaren PJ, Telenti A, Cardona PJ, Clotet B, Vilaplana C, Martinez-Picado J, Izquierdo-Useros N., Free PMC Article | 01/8/2022 |
| CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169. | CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169.
Fenutria R, Maringer K, Potla U, Bernal-Rubio D, Evans MJ, Harris E, Rahman AH, Fernandez-Sesma A, Ramos I., Free PMC Article | 12/4/2021 |
| SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients. | SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients.
Ostendorf L, Dittert P, Biesen R, Duchow A, Stiglbauer V, Ruprecht K, Bellmann-Strobl J, Seelow D, Stenzel W, Niesner RA, Hauser AE, Paul F, Radbruch H., Free PMC Article | 11/13/2021 |
| SIGLEC1 (CD169) is a sensitive biomarker for the deterioration of the clinical course in childhood systemic lupus erythematosus. | SIGLEC1 (CD169) is a sensitive biomarker for the deterioration of the clinical course in childhood systemic lupus erythematosus.
Stuckrad SLV, Klotsche J, Biesen R, Lieber M, Thumfart J, Meisel C, Unterwalder N, Kallinich T., Free PMC Article | 07/31/2021 |
| Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission. | Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.
Ortillon M, Coudereau R, Cour M, Rimmelé T, Godignon M, Gossez M, Yonis H, Argaud L, Lukaszewicz AC, Venet F, Monneret G., Free PMC Article | 05/22/2021 |
| CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department. | CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.
Bourgoin P, Soliveres T, Barbaresi A, Loundou A, Belkacem IA, Arnoux I, Bernot D, Loosveld M, Morange PE, Michelet P, Malergue F, Markarian T., Free PMC Article | 05/22/2021 |
| Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. | Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.
Dupont M, Souriant S, Balboa L, Vu Manh TP, Pingris K, Rousset S, Cougoule C, Rombouts Y, Poincloux R, Ben Neji M, Allers C, Kaushal D, Kuroda MJ, Benet S, Martinez-Picado J, Izquierdo-Useros N, Sasiain MDC, Maridonneau-Parini I, Neyrolles O, Vérollet C, Lugo-Villarino G., Free PMC Article | 03/27/2021 |
| Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019. | Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.
Bedin AS, Makinson A, Picot MC, Mennechet F, Malergue F, Pisoni A, Nyiramigisha E, Montagnier L, Bollore K, Debiesse S, Morquin D, Veyrenche N, Renault C, Foulongne V, Bret C, Bourdin A, Le Moing V, Van de Perre P, Tuaillon E., Free PMC Article | 03/6/2021 |
| Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease. | Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease.
Tanno A, Fujino N, Yamada M, Sugiura H, Hirano T, Tanaka R, Sano H, Suzuki S, Okada Y, Ichinose M., Free PMC Article | 10/24/2020 |
| circulating dendritic cell precursors, but not other blood dendritic cell subsets, are susceptible to infection by HIV-1 in a Siglec-1-dependent manner. This constitutes a unique functional feature that might represent a preferential relationship of this emerging cell type with viruses. | Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors.
Ruffin N, Gea-Mallorquí E, Brouiller F, Jouve M, Silvin A, See P, Dutertre CA, Ginhoux F, Benaroch P., Free PMC Article | 04/11/2020 |
| In vitro, respiratory syncytial virus (RSV) increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited Interferon gamma production by adult CD4(+) T cells. In contrast,Interferon gamma production by RSV in newborns was not affected by Siglec-1. | Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.
Jans J, Unger WWJ, Vissers M, Ahout IML, Schreurs I, Wickenhagen A, de Groot R, de Jonge MI, Ferwerda G., Free PMC Article | 01/26/2019 |
| suggest that high expression of CD169 in lymph node sinus macrophages reflects a high potential for anti-cancer immune responses in esophageal cancer patients | High CD169 expression in lymph node macrophages predicts a favorable clinical course in patients with esophageal cancer.
Takeya H, Shiota T, Yagi T, Ohnishi K, Baba Y, Miyasato Y, Kiyozumi Y, Yoshida N, Takeya M, Baba H, Komohara Y. | 01/19/2019 |
| SIGLEC1 mRNA levels have potential as a novel predictive biomarker for Graves disease relapse. | Sialic Acid-Binding Immunoglobulin-Like Lectin1 as a Novel Predictive Biomarker for Relapse in Graves' Disease: A Multicenter Study.
Hashimoto K, Nishihara E, Matsumoto M, Matsumoto S, Nakajima Y, Tsujimoto K, Yamakage H, Satoh-Asahara N, Noh JY, Ito K, Miyauchi A, Mori M, Yamada M, Ogawa Y. | 12/22/2018 |
| classical HIV-1 infectious routes may compensate for the lack of Siglec-1 in fuelling HIV-1 dissemination within infected individuals | Identification of Siglec-1 null individuals infected with HIV-1.
Martinez-Picado J, McLaren PJ, Erkizia I, Martin MP, Benet S, Rotger M, Dalmau J, Ouchi D, Wolinsky SM, Penugonda S, Günthard HF, Fellay J, Carrington M, Izquierdo-Useros N, Telenti A., Free PMC Article | 09/8/2018 |
| Our findings evidenced for the first time the novel association between SIGLEC1 rs3859664 SNP and active pulmonary TB. Intriguingly, carriers of the polymorphism produced less IL-1ss than non-carriers, suggesting the possible involvement of Siglec-1 signalling pathway with inflammasome complex. | Polymorphisms in SIGLEC1 contribute to susceptibility to pulmonary active tuberculosis possibly through the modulation of IL-1ß.
Souza de Lima D, Nunes VCL, Ogusku MM, Sadahiro A, Pontillo A, Alencar BC. | 06/23/2018 |
| the antibody-sialidase conjugate desialylated tumor cells in a HER2-dependent manner, reduced binding by natural killer (NK) cell inhibitory sialic acid-binding Ig-like lectin (Siglec) receptors, and enhanced binding to the NK-activating receptor natural killer group 2D (NKG2D). | Precision glycocalyx editing as a strategy for cancer immunotherapy.
Xiao H, Woods EC, Vukojicic P, Bertozzi CR., Free PMC Article | 02/10/2018 |