| Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India. | Novel Mutations Reduce Expression of Meiotic Regulators SYCE1 and BOLL in Testis of Azoospermic Men from West Bengal, India.
Pal S, Paladhi P, Dutta S, Mullick RB, Bose G, Ghosh P, Chattopadhyay R, Ghosh S. | 03/27/2024 |
| Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes. | Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.
Zhang W, Chen W, Cui Y, Wen L, Yuan Q, Zhou F, Qiu Q, Sun M, Li Z, He Z., Free PMC Article | 03/19/2022 |
| Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS. | Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis.
Cheng YS, Lu CW, Lin TY, Lin PY, Lin YM. | 12/22/2018 |
| hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility | Highly conserved epigenetic regulation of BOULE and DAZL is associated with human fertility.
Zhang C, Xue P, Gao L, Chen X, Lin K, Yang X, Dai Y, Xu EY. | 09/9/2017 |
| Our study demonstrated an oncogenic role of BOLL in CRC despite tumor-specific promoter hypermethylation. | Oncogenic Role of BOLL in Colorectal Cancer.
Kang KJ, Pyo JH, Ryu KJ, Kim SJ, Ha JM, Choi K, Hong SN, Min BH, Chang DK, Son HJ, Rhee PL, Kim JJ, Kim YH. | 08/15/2015 |
| demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl | A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.
He J, Stewart K, Kinnell HL, Anderson RA, Childs AJ., Free PMC Article | 07/19/2014 |
| Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies. | CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval.
Kleiman SE, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, Yogev L. | 07/30/2011 |
| expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population | Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population.
Chen P, Ma M, Li L, Zhang S, Su D, Ma Y, Liu Y, Tao D, Lin L, Yang Y, Chen P, Ma M, Li L, Zhang S, Su D, Ma Y, Liu Y, Tao D, Lin L, Yang Y. | 06/28/2010 |
| human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes | Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation.
Kee K, Angeles VT, Flores M, Nguyen HN, Reijo Pera RA., Free PMC Article | 01/21/2010 |
| CDC25A is subject to translational control by BOLL, which is an evolutionarily conserved mechanism. | Posttranscriptional regulation of CDC25A by BOLL is a conserved fertility mechanism essential for human spermatogenesis.
Lin YM, Chung CL, Cheng YS. | 01/21/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis.
Westerveld GH, Repping S, Leschot NJ, van der Veen F, Lombardi MP, Westerveld GH, Repping S, Leschot NJ, van der Veen F, Lombardi MP. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesPhenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population.
Chen P, Ma M, Li L, Zhang S, Su D, Ma Y, Liu Y, Tao D, Lin L, Yang Y, Chen P, Ma M, Li L, Zhang S, Su D, Ma Y, Liu Y, Tao D, Lin L, Yang Y. Mutation analysis of the BOULE gene in men with non-obstructive azoospermia: identification of a novel polymorphic variant in the black population.
Lepretre AC, Patrat C, Jouannet P, Bienvenu T, Lepretre AC, Patrat C, Jouannet P, Bienvenu T. | 03/13/2008 |
| BOULE coding sequence mutations are not an important factor in the aetiology of azoospermia. | Mutation analysis of the BOULE gene in men with non-obstructive azoospermia: identification of a novel polymorphic variant in the black population.
Lepretre AC, Patrat C, Jouannet P, Bienvenu T, Lepretre AC, Patrat C, Jouannet P, Bienvenu T. | 01/21/2010 |
| Role in spermatogenesis. Decreased DAZ proteins in spermatogenic failure may be due to germ cell loss. Transcription of BOULE, DAZL, and DAZ not altered in degrees of spermatogenic failure. No increase of DAZL or BOULE found in DAZ deletion. | Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure.
Kuo PL, Wang ST, Lin YM, Lin YH, Teng YN, Hsu CC. | 01/21/2010 |
| Among the three BOULE isoforms, B2 might have the major role for meiotic completion. | Association of three isoforms of the meiotic BOULE gene with spermatogenic failure in infertile men.
Kostova E, Yeung CH, Luetjens CM, Brune M, Nieschlag E, Gromoll J. | 01/21/2010 |
| mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis. | Mutations in the human BOULE gene are not a major cause of impaired spermatogenesis.
Westerveld GH, Repping S, Leschot NJ, van der Veen F, Lombardi MP, Westerveld GH, Repping S, Leschot NJ, van der Veen F, Lombardi MP. | 01/21/2010 |
| BOULE may encode a key conserved switch that regulates progression of germ cells through meiosis in men. | Human BOULE gene rescues meiotic defects in infertile flies.
Xu EY, Lee DF, Klebes A, Turek PJ, Kornberg TB, Reijo Pera RA. | 01/21/2010 |
| Major group of infertile men with meiotic arrest lack BOULE protein and its putative target, CDC25A expression. Spermatogenic failure may arise from factor(s) upstream of BOULE possibly involved in regulating transcription and/or translation of BOULE. | Association of meiotic arrest with lack of BOULE protein expression in infertile men.
Luetjens CM, Xu EY, Rejo Pera RA, Kamischke A, Nieschlag E, Gromoll J. | 01/21/2010 |