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    SLC10A1 solute carrier family 10 member 1 [ Homo sapiens (human) ]

    Gene ID: 6554, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease.

    SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease.
    Ko YL, Tuan WL, Teng MS, Su WC, Wang CC, Er LK, Wu S, Hsu LA.

    06/26/2024
    Molecular mechanisms of Na[+]-driven bile acid transport in human NTCP.

    Molecular mechanisms of Na(+)-driven bile acid transport in human NTCP.
    Lu X, Huang J.,

    05/29/2024
    Association between NTCP hepatic expression and inflammation/fibrosis as well as gender-specific differences in chronic HBV-infected patients.

    Association between NTCP hepatic expression and inflammation/fibrosis as well as gender-specific differences in chronic HBV-infected patients.
    Shi J, Wang X, Qi W, Wang S, Fu Y, Zhang Y, Zhang Q, Han L, Xu Y, Duan H, Liu J, Cong X, Zhou C, Zhao P, Wang J.

    02/20/2024
    Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics.

    Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics.
    Zhang Z, Zhang Q, Zhang Y, Lou Y, Ge L, Zhang W, Zhang W, Song F, Huang P.

    01/3/2024
    Aborted infection of human sodium taurocholate cotransporting polypeptide (hNTCP) expressing woodchuck hepatocytes with hepatitis B virus (HBV).

    Aborted infection of human sodium taurocholate cotransporting polypeptide (hNTCP) expressing woodchuck hepatocytes with hepatitis B virus (HBV).
    Yang L, Zhou D, Martin K, Wu J, Chen M, Lu M, Yang D, Protzer U, Roggendorf M, Song J.

    11/27/2023
    Interactions of Na[+]/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy.

    Interactions of Na(+)/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy.
    Zakrzewicz D, Geyer J.

    06/18/2023
    LINC00659 Inhibits Hepatocellular Carcinoma Malignant Progression by Blocking Aerobic Glycolysis through FUS Recruitment and SLC10A1 Modulation.

    LINC00659 Inhibits Hepatocellular Carcinoma Malignant Progression by Blocking Aerobic Glycolysis through FUS Recruitment and SLC10A1 Modulation.
    Chen B, Xu X, Wu W, Zheng K, Yu Y., Free PMC Article

    05/30/2023
    Genetic variants of NTCP gene and hepatitis B vaccine failure in Taiwanese children of hepatitis B e antigen positive mothers.

    Genetic variants of NTCP gene and hepatitis B vaccine failure in Taiwanese children of hepatitis B e antigen positive mothers.
    Chen YH, Tsuei DJ, Lai MW, Wen WH, Chiang CL, Wu JF, Chen HL, Hsu HY, Ni YH, Chang MH.

    08/13/2022
    Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.

    Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.
    Tremmel R, Nies AT, van Eijck BAC, Handin N, Haag M, Winter S, Büttner FA, Kölz C, Klein F, Mazzola P, Hofmann U, Klein K, Hoffmann P, Nöthen MM, Gaugaz FZ, Artursson P, Schwab M, Schaeffeler E., Free PMC Article

    07/23/2022
    The relationship between NTCP gene varieties and the progress of liver disease after HBV infection: an updated systematic review and meta-analysis.

    The relationship between NTCP gene varieties and the progress of liver disease after HBV infection: an updated systematic review and meta-analysis.
    He C, He HY, Sun CF, Ojha SC, Wang H, Deng CL, Sheng YJ.

    07/16/2022
    Structural insights into the HBV receptor and bile acid transporter NTCP.

    Structural insights into the HBV receptor and bile acid transporter NTCP.
    Park JH, Iwamoto M, Yun JH, Uchikubo-Kamo T, Son D, Jin Z, Yoshida H, Ohki M, Ishimoto N, Mizutani K, Oshima M, Muramatsu M, Wakita T, Shirouzu M, Liu K, Uemura T, Nomura N, Iwata S, Watashi K, Tame JRH, Nishizawa T, Lee W, Park SY., Free PMC Article

    07/9/2022
    Structure of the bile acid transporter and HBV receptor NTCP.

    Structure of the bile acid transporter and HBV receptor NTCP.
    Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U.

    07/9/2022
    Structural basis of sodium-dependent bile salt uptake into the liver.

    Structural basis of sodium-dependent bile salt uptake into the liver.
    Goutam K, Ielasi FS, Pardon E, Steyaert J, Reyes N., Free PMC Article

    07/9/2022
    Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.

    Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.
    Salhab A, Amer J, Lu Y, Safadi R., Free PMC Article

    06/18/2022
    NTCP polymorphisms were associated with fibrosis development in patients with chronic HBV infection.

    NTCP polymorphisms were associated with fibrosis development in patients with chronic HBV infection.
    Su Z, Cai B, Wu X, Li L, Wei B, Meng L, Wang L, Wang L.

    04/9/2022
    Role of serum organic solute transporter alpha/beta and sodium taurocholate cotransporting polypeptide in intrahepatic cholestasis of pregnancy.

    Role of serum organic solute transporter alpha/beta and sodium taurocholate cotransporting polypeptide in intrahepatic cholestasis of pregnancy.
    İrak K, Bayram M, Cifci S, Acar Z, Kazezoğlu C, Yorulmaz E, Yildirim S.

    04/2/2022
    Concentration of Na(+)-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus.

    Concentration of Na(+)-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus.
    Oswald A, Chakraborty A, Ni Y, Wettengel JM, Urban S, Protzer U., Free PMC Article

    01/1/2022
    NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization.

    NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization.
    Fukano K, Oshima M, Tsukuda S, Aizaki H, Ohki M, Park SY, Wakita T, Wakae K, Watashi K, Muramatsu M., Free PMC Article

    12/25/2021
    NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings.

    NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings.
    Mao F, Wang MX, Hou X, Zhou Z, Yan YY, Fang LJ, Tan Z, Fang WY, Liu T, He W, Li C, Xie XB, Lu SQ, Sui J, Wang F, Han J, Wang JS, Li W., Free PMC Article

    12/25/2021
    Assessment of Statin Interactions With the Human NTCP Transporter Using a Novel Fluorescence Assay.

    Assessment of Statin Interactions With the Human NTCP Transporter Using a Novel Fluorescence Assay.
    Wang Y, Wilkerson M, Li J, Zhang W, Owens A, Wright S, Hidalgo I.

    09/25/2021
    A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position.

    A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position.
    Ruggiero MJ, Malhotra S, Fenton AW, Swint-Kruse L, Karanicolas J, Hagenbuch B., Free PMC Article

    09/18/2021
    Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP).

    Hyperosmolarity stimulates transporter-mediated insertion of estrone sulfate into the plasma membrane, but inhibits the uptake by SLC10A1 (NTCP).
    Müller JP, Keufgens L, Gründemann D.

    07/3/2021
    Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency.

    Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency.
    Yan YY, Wang MX, Gong JY, Liu LL, Setchell KDR, Xie XB, Wang NL, Li W, Wang JS.

    07/3/2021
    In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na(+)-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1).

    In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na(+)-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1).
    Russell LE, Zhou Y, Lauschke VM, Kim RB.

    05/29/2021
    NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population.

    NTCP gene polymorphisms and hepatitis B virus infection status in a Ghanaian population.
    Nyarko E, Obirikorang C, Owiredu WKBA, Adu EA, Acheampong E, Aidoo F, Ofori E, Addy BS, Asare-Anane H., Free PMC Article

    04/13/2021
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