| Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1. | Acidic preconditioning induced intracellular acid adaptation to protect renal injury via dynamic phosphorylation of focal adhesion kinase-dependent activation of sodium hydrogen exchanger 1.
Chen A, Zhang J, Yan Z, Lu Y, Chen W, Sun Y, Gu Q, Li F, Yang Y, Qiu S, Lin X, Zhang D, Teng J, Fang Y, Shen B, Song N, Ding X., Free PMC Article | 08/26/2024 |
| Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma. | Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma.
Hayashi Y, Miyoshi S, Watanabe I, Yano N, Nagashio K, Kaneko M, Kaminota T, Sanada T, Hosokawa Y, Kitani T, Mitani S, Choudhury ME, Yano H, Tanaka J, Hato N. | 06/26/2024 |
| Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells. | Requirement of Na+/H+ Exchanger NHE1 for Vasopressin-Induced Osteogenic Signaling and Calcification in Human Aortic Smooth Muscle Cells.
Zhu X, Ma K, Zhou K, Pan X, Liu J, Nürnberg B, Alesutan I, Völkl J, Lang F. | 06/25/2022 |
| Permissive role of Na(+)/H(+) exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells. | Permissive role of Na(+)/H(+) exchanger isoform 1 in migration and invasion of triple-negative basal-like breast cancer cells.
Li X, Fliegel L. | 03/26/2022 |
| Hypoxia enhances motility and EMT through the Na(+)/H(+) exchanger NHE-1 in MDA-MB-231 breast cancer cells. | Hypoxia enhances motility and EMT through the Na(+)/H(+) exchanger NHE-1 in MDA-MB-231 breast cancer cells.
Takatani-Nakase T, Matsui C, Hosotani M, Omura M, Takahashi K, Nakase I. | 02/12/2022 |
| The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma. | The positive feedback loop of NHE1-ERK phosphorylation mediated by BRAF(V600E) mutation contributes to tumorigenesis and development of glioblastoma.
Li Y, Li D, Liu Y, Wang S, Sun M, Zhang Z, Zheng X, Li J, Li Y. | 02/12/2022 |
| Roles of the Na(+)/H(+) Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion. | Roles of the Na(+)/H(+) Exchanger Isoform 1 and Urokinase in Prostate Cancer Cell Migration and Invasion.
Li X, Buckley B, Stoletov K, Jing Y, Ranson M, Lewis JD, Kelso M, Fliegel L., Free PMC Article | 02/5/2022 |
| Dynamic Na(+)/H(+) exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation. | Dynamic Na(+)/H(+) exchanger 1 (NHE1) - calmodulin complexes of varying stoichiometry and structure regulate Ca(2+)-dependent NHE1 activation.
Sjøgaard-Frich LM, Prestel A, Pedersen ES, Severin M, Kristensen KK, Olsen JG, Kragelund BB, Pedersen SF., Free PMC Article | 01/29/2022 |
| Amino Acids 785, 787 of the Na(+)/H(+) Exchanger Cytoplasmic Tail Modulate Protein Activity and Tail Conformation. | Amino Acids 785, 787 of the Na(+)/H(+) Exchanger Cytoplasmic Tail Modulate Protein Activity and Tail Conformation.
Li X, Tu T, Quan S, Quintero FJ, Fahlman R, Fliegel L., Free PMC Article | 01/15/2022 |
| Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett's Esophageal Cell Line. | Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett's Esophageal Cell Line.
Becskeházi E, Korsós MM, Gál E, Tiszlavicz L, Hoyk Z, Deli MA, Köhler ZM, Keller-Pintér A, Horváth A, Csekő K, Helyes Z, Hegyi P, Venglovecz V., Free PMC Article | 11/6/2021 |
| Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells. | Ethyl isopropyl amiloride decreases oxidative phosphorylation and increases mitochondrial fusion in clonal untransformed and cancer cells.
Manoli SS, Kisor K, Webb BA, Barber DL., Free PMC Article | 09/11/2021 |
| Characterization of intracellular buffering power in human induced pluripotent stem cells and the loss of pluripotency is delayed by acidic stimulation and increase of NHE1 activity. | Characterization of intracellular buffering power in human induced pluripotent stem cells and the loss of pluripotency is delayed by acidic stimulation and increase of NHE1 activity.
Lee SP, Chao SC, Chou MF, Huang SF, Dai NT, Wu GJ, Tsai CS, Loh SH, Tsai YT. | 09/11/2021 |
| Role of Genetic Mutations of the Na(+)/H(+) Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity. | Role of Genetic Mutations of the Na(+)/H(+) Exchanger Isoform 1, in Human Disease and Protein Targeting and Activity.
Fliegel L. | 07/17/2021 |
| Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species. | Sodium Glucose Co-Transporter 2 Inhibitors Ameliorate Endothelium Barrier Dysfunction Induced by Cyclic Stretch through Inhibition of Reactive Oxygen Species.
Li X, Römer G, Kerindongo RP, Hermanides J, Albrecht M, Hollmann MW, Zuurbier CJ, Preckel B, Weber NC., Free PMC Article | 07/17/2021 |
| The intracellular lipid-binding domain of human Na(+)/H(+) exchanger 1 forms a lipid-protein co-structure essential for activity. | The intracellular lipid-binding domain of human Na(+)/H(+) exchanger 1 forms a lipid-protein co-structure essential for activity.
Hendus-Altenburger R, Vogensen J, Pedersen ES, Luchini A, Araya-Secchi R, Bendsoe AH, Prasad NS, Prestel A, Cardenas M, Pedraz-Cuesta E, Arleth L, Pedersen SF, Kragelund BB., Free PMC Article | 07/3/2021 |
| Type-1 Na(+)/H(+) exchanger is a prognostic factor and associate with immune infiltration in liver hepatocellular carcinoma. | Type-1 Na(+)/H(+) exchanger is a prognostic factor and associate with immune infiltration in liver hepatocellular carcinoma.
Zhou YT, Chen H, Ai M, Li SS, Li BY, Zhao Y, Cai WW, Hou B, Ni LL, Xu F, Qiu LY. | 07/3/2021 |
| Structure and mechanism of the human NHE1-CHP1 complex. | Structure and mechanism of the human NHE1-CHP1 complex.
Dong Y, Gao Y, Ilie A, Kim D, Boucher A, Li B, Zhang XC, Orlowski J, Zhao Y., Free PMC Article | 06/26/2021 |
| Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors. | Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
Buckley BJ, Kumar A, Aboelela A, Bujaroski RS, Li X, Majed H, Fliegel L, Ranson M, Kelso MJ., Free PMC Article | 04/24/2021 |
| Roles of hsa-miR-12462 and SLC9A1 in acute myeloid leukemia. | Roles of hsa-miR-12462 and SLC9A1 in acute myeloid leukemia.
Jia Y, Liu W, Zhan HE, Yi XP, Liang H, Zheng QL, Jiang XY, Zhou HY, Zhao L, Zhao XL, Zeng H., Free PMC Article | 04/13/2021 |
| our results suggest that dysregulation of NHE1 contributes to breaches in blood brain barrier integrity, drug penetrance, and the behavioral sensitivity to the antimigraine agent, sumatriptan. | Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake.
Liktor-Busa E, Blawn KT, Kellohen KL, Wiese BM, Verkhovsky V, Wahl J, Vivek A, Palomino SM, Davis TP, Vanderah TW, Largent-Milnes TM., Free PMC Article | 07/25/2020 |
| Findings imply that Na/H exchanger 1 (NHE1) is a potential target in cytotoxic or differentiation-induction treatment for acute myeloid leukemia (AML). | Induction of apoptosis and differentiation by Na/H exchanger 1 modulation in acute myeloid leukemia cells.
Hyun SY, Na EJ, Jang JE, Chung H, Kim SJ, Kim JS, Kong JH, Shim KY, Lee JI, Min YH, Cheong JW. | 06/27/2020 |
| NHE1 overexpression specifically induces death of induced pluripotent stem cells via sustained ROCK activation, probably caused by an increase in local pH near NHE1 | Overexpression of Na(+)/H(+) exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK.
Wakabayashi S, Morihara H, Yokoe S, Nakagawa T, Moriwaki K, Tomoda K, Asahi M., Free PMC Article | 06/27/2020 |
| By measuring the kinetic parameters of the NHE1 activity in the oncogene-transformed cells, it was found that NHE1 was constitutively activated by the oncogene expression via an increased sensitivity of its allosteric proton regulatory sites for the intracellular H+. This (the lowering of the H+-sensitivity threshold of NHE1) was responsible for its constitutive activation and the subsequent extracellular acidification | The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela.
Cardone RA, Alfarouk KO, Elliott RL, Alqahtani SS, Ahmed SBM, Aljarbou AN, Greco MR, Cannone S, Reshkin SJ., Free PMC Article | 01/11/2020 |
| NHE1 (Na+/H+ exchanger 1) expression and ERK1/2 phosphorylation decreased along with CIAPIN1 upregulation. | CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy.
Wang J, Zhou Y, Ma L, Cao S, Gao W, Xiong Q, Wang K, Yang L., Free PMC Article | 12/21/2019 |
| Study shows how calcineurin (CN) is recruited to plasma membrane Na+/H+ exchanger 1 (NHE1) and identify an NHE1 phosphorylation site, T779, that is critical for regulating NHE1 transport activity. CN specifically dephosphorylates pT779 to return NHE1 activity to basal levels. | Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin.
Hendus-Altenburger R, Wang X, Sjøgaard-Frich LM, Pedraz-Cuesta E, Sheftic SR, Bendsøe AH, Page R, Kragelund BB, Pedersen SF, Peti W., Free PMC Article | 12/21/2019 |