| NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1alpha into the Nucleus to Inhibit Glioma Invasion. | NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1α into the Nucleus to Inhibit Glioma Invasion.
Liu H, Yu J, Yang L, He P, Li Z., Free PMC Article | 06/23/2023 |
| The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer. | The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
Xia Z, Wang C, Zhang H., Free PMC Article | 06/19/2021 |
| miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA. | miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA.
Valsecchi V, Anzilotti S, Serani A, Laudati G, Brancaccio P, Guida N, Cuomo O, Pignataro G, Annunziato L., Free PMC Article | 04/13/2021 |
| Methylation on SLC8A2 is associated with the development of anti-tuberculosis drug-induced liver injury. | Genome-Wide Analysis of DNA Methylation and Antituberculosis Drug-Induced Liver Injury in the Han Chinese Population.
Huai C, Wei Y, Li M, Zhang X, Wu H, Qiu X, Shen L, Chen L, Zhou W, Zhang N, Zhu G, Zhang Y, Zhang Z, He L, Qin S. | 06/6/2020 |
| Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants | Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.
Khananshvili D. | 08/18/2018 |
| SLC8A2 inhibited the angiogenesis of U87MG cells, probably through combined inhibition of endothelium-dependent and endothelium-nondependent angiogenesis (vascular mimicry pattern). Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma | The Candidate Tumor Suppressor Gene SLC8A2 Inhibits Invasion, Angiogenesis and Growth of Glioblastoma.
Qu M, Yu J, Liu H, Ren Y, Ma C, Bu X, Lan Q., Free PMC Article | 07/14/2018 |
| Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte. | New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.
Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Scorziello A, Di Renzo G, Annunziato L. | 03/16/2013 |
| the large cytosolic loop of NCX1, NCX2, and NCX3 is involved in acquisition of immunosuppressive drug specificity | Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.
Rahamimoff H, Elbaz B, Valitsky M, Khatib M, Eskin-Schwartz M, Elmaz D. | 03/16/2013 |
| NCX isoforms (NCX2, NCX3) contribute to mitochondrial Na(+)/Ca(2+) exchange in human DAergic neurons and may act downstream of PINK1 in the prevention of neurodegeneration by m[Ca(2+)] accumulation. | The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Wood-Kaczmar A, Deas E, Wood NW, Abramov AY. | 03/16/2013 |
| Data suggest that NCX-mediated Ca(2+) fluxes normally exist in human ASM (potentially contributing to rapid Ca(2+) fluxes), and contribute to enhanced [Ca(2+)](i) regulation in airway inflammation. | Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.
Sathish V, Delmotte PF, Thompson MA, Pabelick CM, Sieck GC, Prakash YS., Free PMC Article | 02/18/2012 |
| Results demonstrate a selective regulation of NCX1, NCX2 and NCX3 isoforms in Alzheimer's disease cortex, specifically in terminals containing amyloid-beta. | High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.
Sokolow S, Luu SH, Headley AJ, Hanson AY, Kim T, Miller CA, Vinters HV, Gylys KH., Free PMC Article | 08/27/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| The aim of this study was to investigate if NCX2 might be a tumour suppressor gene involved in glioma. Results indicate that DNA methylation may play a key role in the transcriptional silencing of NCX2. | Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.
Qu M, Jiao H, Zhao J, Ren ZP, Smits A, Kere J, Nistér M. | 08/2/2010 |
| plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins | Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
Pulina MV, Rizzuto R, Brini M, Carafoli E. | 01/21/2010 |