| Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx. | Multivalent, calcium-independent binding of surfactant protein A and D to sulfated glycosaminoglycans of the alveolar epithelial glycocalyx.
Avcibas R, Vermul A, Gluhovic V, Boback N, Arroyo R, Kingma P, Isasi-Campillo M, Garcia-Ortega L, Griese M, Kuebler WM, Ochs M, Lauster D, Lopez-Rodriguez E., Free PMC Article | 05/7/2024 |
| Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model. | Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model.
Jacob IB, Gemmiti A, Xiong W, Reynolds E, Nicholas B, Thangamani S, Jia H, Wang G., Free PMC Article | 04/24/2024 |
| Immunoregulatory function of SP-A. | Immunoregulatory function of SP-A.
Dong S, Pang H, Li F, Hua M, Liang M, Song C. | 02/15/2024 |
| Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway. | Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway.
Yang X, Yang P, Zhang J, Yang Y, Xiong M, Shi F, Li N, Jin Y. | 08/13/2022 |
| Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants. | Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants.
Floros J, Tsotakos N., Free PMC Article | 02/19/2022 |
| SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma. | SFTPA1 is a potential prognostic biomarker correlated with immune cell infiltration and response to immunotherapy in lung adenocarcinoma.
Yuan L, Wu X, Zhang L, Yang M, Wang X, Huang W, Pan H, Wu Y, Huang J, Liang W, Li J, Zhu X, Wang S, Guan J, Liu L., Free PMC Article | 02/12/2022 |
| Association between SP-A rs1965708 gene polymorphism and allergic rhinitis risk in Chinese population. | Association between SP-A rs1965708 gene polymorphism and allergic rhinitis risk in Chinese population.
Yin X, Wang B, Yan Z, Hu L, Zhang X., Free PMC Article | 12/25/2021 |
| Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions. | Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.
Floros J, Thorenoor N, Tsotakos N, Phelps DS., Free PMC Article | 10/30/2021 |
| Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer. | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer.
Moreno-Rubio J, Ponce S, Álvarez R, Olmedo ME, Falagan S, Mielgo X, Navarro F, Cruz P, Cabezón-Gutiérrez L, Aguado C, Colmenarejo G, Muñoz-Fernández de Leglaria M, Enguita AB, Cebollero M, Benito A, Alemany I, Del Castillo C, Ramos R, Ramírez de Molina A, Casado E, Sereno M., Free PMC Article | 10/9/2021 |
| Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer. | Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer.
Legendre M, Butt A, Borie R, Debray MP, Bouvry D, Filhol-Blin E, Desroziers T, Nau V, Copin B, Dastot-Le Moal F, Héry M, Duquesnoy P, Allou N, Bergeron A, Bermudez J, Cazes A, Chene AL, Cottin V, Crestani B, Dalphin JC, Dombret C, Doray B, Dupin C, Giraud V, Gondouin A, Gouya L, Israël-Biet D, Kannengiesser C, Le Borgne A, Leroy S, Longchampt E, Lorillon G, Nunes H, Picard C, Reynaud-Gaubert M, Traclet J, de Vuyst P, Coulomb L'Hermine A, Clement A, Amselem S, Nathan N. | 08/14/2021 |
| Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice. | Differences in the alveolar macrophage toponome in humanized SP-A1 and SP-A2 transgenic mice.
Phelps DS, Chinchilli VM, Weisz J, Yang L, Shearer D, Zhang X, Floros J., Free PMC Article | 05/29/2021 |
| Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae. | Sex-Specific Regulation of Gene Expression Networks by Surfactant Protein A (SP-A) Variants in Alveolar Macrophages in Response to Klebsiella pneumoniae.
Thorenoor N, Kawasawa YI, Gandhi CK, Floros J., Free PMC Article | 04/17/2021 |
| Correlation of pulmonary alveolar surfactant protein-a gene polymorphism with asthma in children. | Correlation of pulmonary alveolar surfactant protein-a gene polymorphism with asthma in children.
Hong L, Liu Y, Huo S. | 03/27/2021 |
| Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival. | Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.
Pocha K, Mock A, Rapp C, Dettling S, Warta R, Geisenberger C, Jungk C, Martins LR, Grabe N, Reuss D, Debus J, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende CC. | 02/6/2021 |
| SP-A and TLR4 localization in lung tissue of SM-exposed patients. | SP-A and TLR4 localization in lung tissue of SM-exposed patients.
Ghaffarpour S, Foroutan A, Askari N, Abbas FM, Salehi E, Nikoonejad M, Naghizadeh MM, Eskandarian M, Moghadam KG, Akbari HMH, Yarmohammadi ME, Ghazanfari T. | 11/28/2020 |
| Recent progress on surfactant protein A: cellular function in lung and kidney disease development. | Recent progress on surfactant protein A: cellular function in lung and kidney disease development.
King SD, Chen SY., Free PMC Article | 10/24/2020 |
| These findings provide new insight into the mechanisms of IPF in which a mutation in SFTPA1 promotes necroptosis of AEII cells through JNK-mediated up-regulation of Ripk3, highlighting the necroptosis pathway as a therapeutic target for IPF. | A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis.
Takezaki A, Tsukumo SI, Setoguchi Y, Ledford JG, Goto H, Hosomichi K, Uehara H, Nishioka Y, Yasutomo K., Free PMC Article | 06/20/2020 |
| A case-control study in China indicated that changes in SP-A expression and distribution in lung tissues may be involved in COPD pathogenesis in smokers. | Surfactant protein A expression and distribution in human lung samples from smokers with or without chronic obstructive pulmonary disease in China.
Liu Z, Chen S, Xu Y, Liu X, Xiong P, Fu Y., Free PMC Article | 03/7/2020 |
| this study shows that full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity | Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity.
Al-Qahtani AA, Murugaiah V, Bashir HA, Pathan AA, Abozaid SM, Makarov E, Nal-Rogier B, Kishore U, Al-Ahdal MN. | 02/29/2020 |
| For the first time, this study could show that infantile labial glands show expression of the surfactant proteins (SP) SP-A, SP-B, SP-C, and SP-D in acinar cells and the duct system in different intensities. | Immunolocalization of Surfactant Proteins SP-A, SP-B, SP-C, and SP-D in Infantile Labial Glands and Mucosa.
Stoeckelhuber M, Feuerhake F, Schmitz C, Wolff KD, Kesting MR., Free PMC Article | 08/3/2019 |
| Decreased levels of SP-A in obese patients with asthma, which could be due to increased local TNF-alpha levels, might lead to impaired eosinophil resolution and could contribute to the eosinophilic asthma phenotype. | Obese asthmatic patients have decreased surfactant protein A levels: Mechanisms and implications.
Lugogo N, Francisco D, Addison KJ, Manne A, Pederson W, Ingram JL, Green CL, Suratt BT, Lee JJ, Sunday ME, Kraft M, Ledford JG., Free PMC Article | 07/20/2019 |
| There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke. | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke.
Kouchaki E, Babamohammadi A, Nikoueinejad H, Sehat M. | 07/6/2019 |
| Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis. | Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis.
Hartjen N, Bräuer L, Reiß B, Claassen H, Beileke S, Garreis F, Hoogeboom S, Tsokos M, Etzold S, Müller-Hilke B, Gelse K, Müller T, Goldring MB, Paulsen F, Schicht M., Free PMC Article | 02/23/2019 |
| This study is suggestive that the PCR (polymerase chain reaction) for the detection of coa, mecA, and spa gene is a fast, accurate, and valuable diagnostic tool. | The coa, mec, and spa genes diversity among methicillin-resistant Staphylococcus aureus Strains from health-care workers and patients.
Al-Ruwaili MA. | 10/27/2018 |
| TGF beta markedly decreased expression of SP-A, SP-B, SP-C, fatty acid synthase, and the phospholipid transporter ABCA3. However, TGF beta increased protein levels of SP-D with little change in mRNA levels. | TGF beta inhibits expression of SP-A, SP-B, SP-C, but not SP-D in human alveolar type II cells.
Correll KA, Edeen KE, Zemans RL, Redente EF, Mikels-Vigdal A, Mason RJ., Free PMC Article | 10/13/2018 |