| The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome. | The association of APOH and NCF1 polymorphisms on susceptibility to recurrent pregnancy loss in women with antiphospholipid syndrome.
Deng X, Sang Q, Zhang R, Mu J, Bao S., Free PMC Article | 09/6/2023 |
| ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes. | ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes.
Tlili A, Pintard C, Hurtado-Nedelec M, Liu D, Marzaioli V, Thieblemont N, Dang PM, El-Benna J., Free PMC Article | 01/14/2023 |
| Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease. | Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease.
Belambri SA, Marzaioli V, Hurtado-Nedelec M, Pintard C, Liang S, Liu Y, Boussetta T, Gougerot-Pocidalo MA, Ye RD, Dang PM, El-Benna J. | 04/30/2022 |
| Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages. | Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages.
Geng L, Zhao J, Deng Y, Molano I, Xu X, Xu L, Ruiz P, Li Q, Feng X, Zhang M, Tan W, Kamen DL, Bae SC, Gilkeson GS, Sun L, Tsao BP. | 02/12/2022 |
| NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma. | NCF1/2/4 Are Prognostic Biomarkers Related to the Immune Infiltration of Kidney Renal Clear Cell Carcinoma.
Chen Y, He F, Wang R, Yao M, Li Y, Guo D, He S., Free PMC Article | 01/29/2022 |
| Neutrophil Cytosolic Factor-1 Genotyping in Acne Vulgaris. | Neutrophil Cytosolic Factor-1 Genotyping in Acne Vulgaris.
Bakry O, Shoeib M, Soliman S, Kamal L. | 10/30/2021 |
| Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis. | Whole genome sequencing identifies variants associated with sarcoidosis in a family with a high prevalence of sarcoidosis.
Fritz D, Ferwerda B, Brouwer MC, van de Beek D., Free PMC Article | 08/21/2021 |
| Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population. | Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population.
Yokoyama N, Kawasaki A, Matsushita T, Furukawa H, Kondo Y, Hirano F, Sada KE, Matsumoto I, Kusaoi M, Amano H, Nagaoka S, Setoguchi K, Nagai T, Shimada K, Sugii S, Hashimoto A, Matsui T, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Migita K, Kono H, Hasegawa M, Kobayashi S, Yamada H, Nagasaka K, Sugihara T, Yamagata K, Ozaki S, Tamura N, Takasaki Y, Hashimoto H, Makino H, Arimura Y, Harigai M, Sato S, Sumida T, Tohma S, Takehara K, Tsuchiya N., Free PMC Article | 11/21/2020 |
| P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK. | P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK.
Cap KC, Kim JG, Hamza A, Park JB. | 09/26/2020 |
| Data showed that proliferating cell nuclear antigen (PCNA) associated with neutrophil cytosolic factor 1 (p47phox), a key subunit of NADPH oxidase in neutrophils and that this association regulated reactive oxygen species (ROS) production. | Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.
Ohayon D, De Chiara A, Dang PM, Thieblemont N, Chatfield S, Marzaioli V, Burgener SS, Mocek J, Candalh C, Pintard C, Tacnet-Delorme P, Renault G, Lagoutte I, Favier M, Walker F, Hurtado-Nedelec M, Desplancq D, Weiss E, Benarafa C, Housset D, Marie JC, Frachet P, El-Benna J, Witko-Sarsat V., Free PMC Article | 06/27/2020 |
| Polymorphism NCF1-339, rs201802880 mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of neutrophil extracellular traps in systemic lupus erythematosus, allowing dependence on mitochondrial reactive oxygen species (ROS). Also a striking connection between the ROS deficient NCF1-339 genotypes and the presence of phospholipid antibodies and antiphospholipid syndrome | NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus.
Linge P, Arve S, Olsson LM, Leonard D, Sjöwall C, Frodlund M, Gunnarsson I, Svenungsson E, Tydén H, Jönsen A, Kahn R, Johansson Å, Rönnblom L, Holmdahl R, Bengtsson A. | 04/25/2020 |
| flow cytometry for p47(phox) expression quickly identifies patients and carriers of p47(phox) CGD, and genomic ddPCR identifies patients and carriers of DeltaGT NCF1, the most common mutation in p47(phox) CGD. | NCF1 (p47(phox))-deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis.
Kuhns DB, Hsu AP, Sun D, Lau K, Fink D, Griffith P, Huang DW, Priel DAL, Mendez L, Kreuzburg S, Zerbe CS, De Ravin SS, Malech HL, Holland SM, Wu X, Gallin JI., Free PMC Article | 01/11/2020 |
| NCF1, a critical gene in the ROS system, was upregulated in THP-1 cell and monocytes under lipopolysaccharides stimulation. Moreover, we identified the upregulation of NCF1 in a sepsis model. | Neutrophil Cytosolic Factor 1 Contributes to the Development of Sepsis.
Chen DF, Cui XZ, Cao WM, Meng W. | 12/21/2019 |
| we identify specific cysteine residues of protein disulfide isomerase and p47phox necessary for the direct interaction of these proteins, the assembly of the Nox1 complex and subsequent activation of Nox1 in vascular disease. | Redox Activation of Nox1 (NADPH Oxidase 1) Involves an Intermolecular Disulfide Bond Between Protein Disulfide Isomerase and p47(phox) in Vascular Smooth Muscle Cells.
Gimenez M, Veríssimo-Filho S, Wittig I, Schickling BM, Hahner F, Schürmann C, Netto LES, Rosa JC, Brandes RP, Sartoretto S, De Lucca Camargo L, Abdulkader F, Miller FJ Jr, Lopes LR., Free PMC Article | 12/7/2019 |
| Activation of PAD4 by membranolytic insults that result in high levels of intracellular calcium (higher than physiological neutrophil activation) leads to rapid citrullination of p47(phox)/NCF1 and p67(phox)/NCF2, as well as their dissociation from PAD4 | Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils.
Zhou Y, An LL, Chaerkady R, Mittereder N, Clarke L, Cohen TS, Chen B, Hess S, Sims GP, Mustelin T., Free PMC Article | 11/9/2019 |
| of the total molecularly characterized Indian patients with chronic granulomatous disease (n = 90), 56% of the patients had a mutation in the NCF1 gene | Approach to Molecular Diagnosis of Chronic Granulomatous Disease (CGD): an Experience from a Large Cohort of 90 Indian Patients.
Kulkarni M, Hule G, de Boer M, van Leeuwen K, Kambli P, Aluri J, Gupta M, Dalvi A, Mhatre S, Taur P, Desai M, Madkaikar M. | 10/5/2019 |
| we discovered the existence of p47(phox) /Hyal2 complex. LSS induced the dissociation of p47(phox) /Hyal2 complex, which was inhibited by LKB1 overexpression and AICAR. Furthermore, knockdown of Hyal2 performed a positive feedback on LKB1 activity | Hyaluronidase2 (Hyal2) modulates low shear stress-induced glycocalyx impairment via the LKB1/AMPK/NADPH oxidase-dependent pathway.
Yang H, Zhu L, Chao Y, Gu Y, Kong X, Chen M, Ye P, Luo J, Chen S. | 10/5/2019 |
| In six additional Ashkenazi carriers of the NCF1 c.579G>A mutation, we found five individuals with three complete NCF1 genes of which one was mutated (like the parents), and one individual with in addition a fusion gene of NCF1 with a pseudogene | A false-carrier state for the c.579G>A mutation in the NCF1 gene in Ashkenazi Jews.
De Boer M, Gavrieli R, van Leeuwen K, Wolf HR, Dushnitzki M, Bar-Yosef Y, Bar-Ziv A, Behar D, Lipitz S, Miller TE, Tool ATJ, Kuijpers TW, van den Berg TK, Wolach B, Roos D, Pras E. | 09/21/2019 |
| Correlation between genotype and phenotype is unpredictable, although clinically, the Kavkazi patients were more severely affected than other patients with p47phox deficiency. | Analysis of Chronic Granulomatous Disease in the Kavkazi Population in Israel Reveals Phenotypic Heterogeneity in Patients with the Same NCF1 mutation (c.579G>A).
Wolach B, Gavrieli R, de Boer M, van Leeuwen K, Wolach O, Grisaru-Soen G, Broides A, Etzioni A, Somech R, Roos D. | 07/27/2019 |
| this study shows genetic and molecular findings of 38 Iranian patients with chronic granulomatous disease caused by p47-phox defect | Genetic and molecular findings of 38 Iranian patients with chronic granulomatous disease caused by p47-phox defect.
Tajik S, Badalzadeh M, Fazlollahi MR, Houshmand M, Bazargan N, Movahedi M, Mahlouji Rad M, Mahdaviani SA, Mamishi S, Khotaei GT, Mansouri D, Zandieh F, Pourpak Z. | 07/13/2019 |
| Our findings in experiments on activated human retinal endothelial cells provide translational corroboration of studies in experimental models of retinal vasculopathy and support the therapeutic application of Nox4 inhibition by GKT136901 and GKT137831 in patients with retinal vascular diseases. | Effect of NADPH oxidase 1 and 4 blockade in activated human retinal endothelial cells.
Appukuttan B, Ma Y, Stempel A, Ashander LM, Deliyanti D, Wilkinson-Berka JL, Smith JR. | 06/29/2019 |
| Tyrosine kinase substrate (Tks) proteins, analogous to the related proteins p47(phox), p40(phox) and NoxO1, also facilitate local generation of reactive oxygen species (ROS), which aid in signaling at invadopodia and/or podosomes to promote their activity. As their name suggests, Tks adaptor proteins are substrates for tyrosine kinases, especially Src. [review] | Tks adaptor proteins at a glance.
Saini P, Courtneidge SA., Free PMC Article | 03/9/2019 |
| IL-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47(phox). | Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox).
Sowrirajan B, Saito Y, Poudyal D, Chen Q, Sui H, DeRavin SS, Imamichi H, Sato T, Kuhns DB, Noguchi N, Malech HL, Lane HC, Imamichi T., Free PMC Article | 11/3/2018 |
| p47phox, but not p67phox or p40phox, binds to and activates Nrf2, enhancing the function of Nrf2 in suppressing inflammation. | Suppressed ubiquitination of Nrf2 by p47(phox) contributes to Nrf2 activation.
Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M., Free PMC Article | 09/15/2018 |
| p47phox S-glutathionylation plays an essential key role in the sustained ROS generation by human neutrophils. | S-Glutathionylation of p47phox sustains superoxide generation in activated neutrophils.
Nagarkoti S, Dubey M, Awasthi D, Kumar V, Chandra T, Kumar S, Dikshit M. | 04/21/2018 |