| PKCdelta-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. | PKCδ-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs.
Chen CH, Wang BW, Hsiao YC, Wu CY, Cheng FJ, Hsia TC, Chen CY, Wang Y, Weihua Z, Chou RH, Tang CH, Chen YJ, Wei YL, Hsu JL, Tu CY, Hung MC, Huang WC., Free PMC Article | 08/28/2024 |
| SLC5A1 Variants in Turkish Patients with Congenital Glucose-Galactose Malabsorption. | SLC5A1 Variants in Turkish Patients with Congenital Glucose-Galactose Malabsorption.
Hoşnut FÖ, Janecke AR, Şahin G, Vogel GF, Lafcı NG, Bichler P, Müller T, Huber LA, Valovka T, Aksu AÜ., Free PMC Article | 08/9/2023 |
| Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum. | Obesity and overweight are linked to increased sodium-glucose cotransporter 1 and glucose transporter 5 levels in duodenum.
Fiorentino TV, De Vito F, Suraci E, Marasco R, Hribal ML, Luzza F, Sesti G. | 02/28/2023 |
| Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy. | Decreased expression of Glucagon-like peptide-1 receptor and Sodium-glucose co-transporter 2 in patients with proliferative diabetic retinopathy.
Chen H, Zhang X, Liao N, Ji Y, Mi L, Gan Y, Su Y, Wen F., Free PMC Article | 12/17/2022 |
| Structure and mechanism of the SGLT family of glucose transporters. | Structure and mechanism of the SGLT family of glucose transporters.
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L., Free PMC Article | 05/7/2022 |
| A risk model of gene signatures for predicting platinum response and survival in ovarian cancer. | A risk model of gene signatures for predicting platinum response and survival in ovarian cancer.
Chen S, Wu Y, Wang S, Wu J, Wu X, Zheng Z., Free PMC Article | 04/9/2022 |
| New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans. | New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans.
Ferté L, Marino A, Battault S, Bultot L, Van Steenbergen A, Bol A, Cumps J, Ginion A, Koepsell H, Dumoutier L, Hue L, Horman S, Bertrand L, Beauloye C., Free PMC Article | 03/28/2021 |
| Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer. | Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer.
Wang J, Ji H, Niu X, Yin L, Wang Y, Gu Y, Li D, Zhang H, Lu M, Zhang F, Zhang Q., Free PMC Article | 02/6/2021 |
| Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes. | Expression of glucose transporters in duodenal mucosa of patients with type 1 diabetes.
Bolla AM, Butera E, Pellegrini S, Caretto A, Bonfanti R, Zuppardo RA, Barera G, Cavestro GM, Sordi V, Bosi E. | 12/12/2020 |
| SGLT1 depletion results in decreased levels of phospho-EGFR, and as a result, the activity of downstream signalling pathways (such as AKT and ERK) is inhibited. Hence, targeting SGLT1 itself or the EGFR-SGLT1 interaction may provide novel therapeutics against triple-negative breast cancer. | SGLT1 is required for the survival of triple-negative breast cancer cells via potentiation of EGFR activity.
Liu H, Ertay A, Peng P, Li J, Liu D, Xiong H, Zou Y, Qiu H, Hancock D, Yuan X, Huang WC, Ewing RM, Downward J, Wang Y., Free PMC Article | 05/2/2020 |
| This study showed that SGLT2 mRNA expression was lower in diabetic kidney disease compared with controls or glomerulonephritis and inversely related to interstitial fibrosis. | Renal SGLT mRNA expression in human health and disease: a study in two cohorts.
Srinivasan Sridhar V, Ambinathan JPN, Kretzler M, Pyle LL, Bjornstad P, Eddy S, Cherney DZ, Reich HN, European Renal cDNA Bank (ERCB);, Nephrotic Syndrome Study Network (NEPTUNE)., Free PMC Article | 04/11/2020 |
| Functionally damaging missense variants in SGLT1 protect from diet-induced Hyperglycemia. Reduced intestinal glucose uptake may protect from long-term Cardiometabolic outcomes. | Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk.
Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD., Free PMC Article | 09/14/2019 |
| Here we show that both human and murine endometrial epithelial cells express the high affinity Na(+)-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (Slc5a1 (+/+)) but not in SGLT1 deficient (Slc5a1 (-/-)) mice. | Loss of Endometrial Sodium Glucose Cotransporter SGLT1 is Detrimental to Embryo Survival and Fetal Growth in Pregnancy.
Salker MS, Singh Y, Zeng N, Chen H, Zhang S, Umbach AT, Fakhri H, Kohlhofer U, Quintanilla-Martinez L, Durairaj RRP, Barros FSV, Vrljicak P, Ott S, Brucker SY, Wallwiener D, Vrhovac Madunić I, Breljak D, Sabolić I, Koepsell H, Brosens JJ, Lang F., Free PMC Article | 06/29/2019 |
| Sanger sequencing for the full coding regions of SLC5A1 resulted in the identification of 4 allelic variants in a homozygous state. Two mutations are novel and 2 have been previously reported to cause Congenital Glucose-Galactose Malabsorption | SLC5A1 Mutations in Saudi Arabian Patients With Congenital Glucose-Galactose Malabsorption.
Al-Suyufi Y, ALSaleem K, Al-Mehaidib A, Banemai M, Aldekhail WM, Al-Muhandes A, Mohammed M, Allam R, Jambi A, Ramzan K, Imtiaz F. | 04/20/2019 |
| SGLT1, SGLT2 and GLUT2 have roles in renal glucose handling [review] | Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.
Ghezzi C, Loo DDF, Wright EM., Free PMC Article | 02/2/2019 |
| Only the index variant in SLC5A1 showed a significant association with fasting glucose in the expected opposing direction. Products of genes in all 1,5-AG-associated loci have known roles in carbohydrate digestion and enteral or renal glucose transport, suggesting that genetic variants associated with 1,5-AG influence its concentration via effects on glucose metabolism and handling | Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism.
Li M, Maruthur NM, Loomis SJ, Pietzner M, North KE, Mei H, Morrison AC, Friedrich N, Pankow JS, Nauck M, Boerwinkle E, Teumer A, Selvin E, Köttgen A., Free PMC Article | 12/22/2018 |
| High glucose levels induce MMP-2 expression in Human cardiac fibroblasts , possibly by up-regulation of SGLT1. | Role of SGLT1 in high glucose level-induced MMP-2 expression in human cardiac fibroblasts.
Meng L, Uzui H, Guo H, Tada H. | 09/22/2018 |
| Data suggest that a fraction of sodium glucose transporter is rapidly degraded by lysosomes and never reached the plasma membrane; another fraction reaches the membrane and is subsequently degraded by lysosomes following internalization. | Real-time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cells.
Ghezzi C, Calmettes G, Morand P, Ribalet B, John S., Free PMC Article | 06/23/2018 |
| Data suggest expression of SGLT1 is markedly increased in kidney of patients with type 2 diabetes as compared to control subjects; SGLT1 mRNA is highly and significantly correlated with fasting and postprandial plasma glucose and HbA1c. In contrast, data suggest SGLT2 and GLUT2 mRNA in kidney are down-regulated in type 2 diabetes, but not to statistically significant level. (GLUT2 = glucose transporter type 2) | Sodium-glucose co-transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects.
Norton L, Shannon CE, Fourcaudot M, Hu C, Wang N, Ren W, Song J, Abdul-Ghani M, DeFronzo RA, Ren J, Jia W. | 05/12/2018 |
| Data suggest that SGLT2 expression is higher in control kidney than in kidney from subjects with type 2 diabetes; SGLT1 expression in kidney tended in the same direction; SGLT2 appears to be localized to tubular brush-border membranes; unaffected renal tissues were obtained from subjects undergoing unilateral nephrectomy for renal carcinomas. | Sodium-glucose co-transporter (SGLT)2 and SGLT1 renal expression in patients with type 2 diabetes.
Solini A, Rossi C, Mazzanti CM, Proietti A, Koepsell H, Ferrannini E. | 05/12/2018 |
| Duodenal SGLT-1 expression is increased in individuals with 1-hour postload hyperglycemia or impaired glucose tolerance, as well as in subjects with T2 Diabetes mellitus, and it positively correlates with early postload glucose excursion. | Duodenal Sodium/Glucose Cotransporter 1 Expression Under Fasting Conditions Is Associated With Postload Hyperglycemia.
Fiorentino TV, Suraci E, Arcidiacono GP, Cimellaro A, Mignogna C, Presta I, Andreozzi F, Hribal ML, Perticone F, Donato G, Luzza F, Sesti G. | 12/9/2017 |
| Homoeriodictyol affects both the glucose metabolism and the serotonin system in Caco-2 cells via a sodium glucose cotransporter 1 protein (SGLT-1)-meditated pathway. | The flavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells.
Lieder B, Hoi JK, Holik AK, Geissler K, Hans J, Friedl B, Liszt K, Krammer GE, Ley JP, Somoza V., Free PMC Article | 08/26/2017 |
| intracellular Na+ and sugar release occurs in a random, independent manner | Stochastic steps in secondary active sugar transport.
Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M., Free PMC Article | 08/12/2017 |
| Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop | The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop.
Sasseville LJ, Morin M, Coady MJ, Blunck R, Lapointe JY., Free PMC Article | 07/22/2017 |
| Binding of RS1-Reg to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose. | Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.
Chintalapati C, Keller T, Mueller TD, Gorboulev V, Schäfer N, Zilkowski I, Veyhl-Wichmann M, Geiger D, Groll J, Koepsell H. | 05/13/2017 |