| Glutamate transporter-associated protein 3-18 (GTRAP3-18), an anchor protein that retains interacting proteins in the endoplasmic reticulum, is a critical regulator of food intake and body weight by interacting with POMC. GTRAP3-18-deficient mice showed hypophagia, lean bodies, and lower blood glucose, insulin, and leptin levels with increased serum and brain alpha-MSH levels, leading to AMPK inhibition. | GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin.
Aoyama K, Bhadhprasit W, Watabe M, Wang F, Matsumura N, Nakaki T. | 11/3/2018 |
| Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis. | JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2.
Zhao X, Wang R, Xiong J, Yan D, Li A, Wang S, Xu J, Zhou J. | 08/12/2017 |
| the JWA deficiency through cascading FAK-PI3K-Akt-mTOR pathway increases the newborn neurons. | Lack of JWA Enhances Neurogenesis and Long-Term Potentiation in Hippocampal Dentate Gyrus Leading to Spatial Cognitive Potentiation.
Sha S, Xu J, Lu ZH, Hong J, Qu WJ, Zhou JW, Chen L. | 10/22/2016 |
| These findings indicated that Arl6ip5 was an anti-catabolic factor by binding with RANKL and disturbing its subcellular trafficking in osteoblast. | Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Wu Y, Wang M, Peng Y, Ding Y, Deng L, Fu Q. | 04/30/2016 |
| Arl6ip5 is a novel regulator of bone formation in osteoblasts. | Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis.
Wu Y, Yang M, Fan J, Peng Y, Deng L, Ding Y, Yang R, Zhou J, Miao D, Fu Q., Free PMC Article | 06/20/2015 |
| This study provided evidence that astrocytic JWA expression protects DA neurons from degeneration and plays an important role in neuroprotection via inhibition of ROS and NF-kappaB activation. | Astrocytic JWA expression is essential to dopaminergic neuron survival in the pathogenesis of Parkinson's disease.
Miao SH, Sun HB, Ye Y, Yang JJ, Shi YW, Lu M, Hu G, Zhou JW., Free PMC Article | 04/4/2015 |
| The double-fluorescent immunohistochemical analysis revealed that addicsin and TR1 were coexpressed in neurons | Identification of tomoregulin-1 as a novel addicsin-associated factor.
Arano T, Fujisaki S, Ikemoto MJ. | 12/27/2014 |
| Data show the importance of JWA (Arl6ip5) in skin homeostasis and in the process of skin tumor development. | JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
Gong Z, Shi Y, Zhu Z, Li X, Ye Y, Zhang J, Li A, Li G, Zhou J., Free PMC Article | 06/30/2012 |
| This study demonistrated that GTRAP3-18(-/-) mice performed better in motor/spatial learning and memory tests. The suppression of GTRAP3-18 increases neuronal resistance to oxidative stress by increasing GSH content and also facilitates cognitive function | Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.
Aoyama K, Wang F, Matsumura N, Kiyonari H, Shioi G, Tanaka K, Kinoshita C, Kikuchi-Utsumi K, Watabe M, Nakaki T. | 06/9/2012 |
| Arl6ip1 is a novel addicsin-associated partner that promotes EAAC1-mediated glutamate transport activity by decreasing the number of addicsin molecules available for interaction with EAAC1. | Modulation of the neural glutamate transporter EAAC1 by the addicsin-interacting protein ARL6IP1.
Akiduki S, Ikemoto MJ. | 04/7/2010 |
| Expression of GTRAP3-18 delays the ER exit of EAAC1, as well as other members of the excitatory amino acid transporter family. | The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein.
Ruggiero AM, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, Robinson MB, Sitte HH, Rothstein JD., Free PMC Article | 01/21/2010 |
| Addicsin mRNA is expressed in CNS neurons and may participate in the functional expression of the somatic sensory system by modulation of EAAC1-mediated glutamate transport. | Expression profile of addicsin/GTRAP3-18 mRNA in mouse brain.
Inoue K, Akiduki S, Ikemoto MJ. | 01/21/2010 |
| Our studies demonstrated that H(2)O(2) is the primary oxidative product responsible for benzo[a]pyrene (B[a]P)-induced JWA expression, and knockdown of JWA elevates H(2)O(2) (100 microM)- and B[a]P (100 microM)-induced DNA damage. | Identification of JWA as a novel functional gene responsive to environmental oxidative stress induced by benzo[a]pyrene and hydrogen peroxide.
Chen R, Qiu W, Liu Z, Cao X, Zhu T, Li A, Wei Q, Zhou J. | 01/21/2010 |
| 98% identity with that of rat GTRAP3-18; upregulated in the amygdala by repeated administration of morphine | Identification of addicsin/GTRAP3-18 as a chronic morphine-augmented gene in amygdala.
Ikemoto MJ, Inoue K, Akiduki S, Osugi T, Imamura T, Ishida N, Ohtomi M. | 01/21/2010 |
| inhibits EAAT3-mediated glutamate uptake; highly conserved protein and genomic organization amongst vertebrates | Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18.
Butchbach ME, Lai L, Lin CL. | 04/27/2003 |