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    SLAMF1 signaling lymphocytic activation molecule family member 1 [ Homo sapiens (human) ]

    Gene ID: 6504, updated on 2-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model.

    Identification of SLAMF1 as an immune-related key gene associated with rheumatoid arthritis and verified in mice collagen-induced arthritis model.
    Li A, Zhang Z, Ru X, Yi Y, Li X, Qian J, Wang J, Yang X, Yao Y., Free PMC Article

    10/1/2022
    SLAMF1 is expressed and secreted by hepatocytes and the liver in nonalcoholic fatty liver disease.

    SLAMF1 is expressed and secreted by hepatocytes and the liver in nonalcoholic fatty liver disease.
    Gomez-Torres O, Amatya S, Kamberov L, Dhaibar HA, Khanna P, Rom O, Yurdagul A Jr, Orr AW, Nunez K, Thevenot P, Cohen A, Samant H, Alexander JS, Burgos-Ramos E, Chapa-Rodriguez A, Cruz-Topete D., Free PMC Article

    08/20/2022
    Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1.

    Neutrophil autophagy during human active tuberculosis is modulated by SLAMF1.
    Pellegrini JM, Sabbione F, Morelli MP, Tateosian NL, Castello FA, Amiano NO, Palmero D, Levi A, Ciallella L, Colombo MI, Trevani AS, García VE., Free PMC Article

    04/16/2022
    SLAMF1/CD150 expression and topology in prostate and breast cancer cell lines.

    SLAMF1/CD150 expression and topology in prostate and breast cancer cell lines.
    Gordiienko IM, Lykhova OO, Shcherbina VM, Shlapatska LM.

    03/19/2022
    SLAM/SAP Decreased Follicular Regulatory T Cells in Patients with Graves' Disease.

    SLAM/SAP Decreased Follicular Regulatory T Cells in Patients with Graves' Disease.
    Geng L, Yang J, Tang X, Peng H, Tian J, Hu Z, Liu Y, Xu H, Wang S., Free PMC Article

    12/4/2021
    CD150 and CD180 are negative regulators of IL-10 expression and secretion in chronic lymphocytic leukemia B cells.

    CD150 and CD180 are negative regulators of IL-10 expression and secretion in chronic lymphocytic leukemia B cells.
    Shcherbina V, Gordiienko I, Shlapatska L, Gluzman D, Sidorenko S.

    08/14/2021
    In chronic lymphocytic leukaemia, SLAMF1 deregulation is associated with genomic complexity and independently predicts a worse outcome.

    In chronic lymphocytic leukaemia, SLAMF1 deregulation is associated with genomic complexity and independently predicts a worse outcome.
    Rigolin GM, Saccenti E, Melandri A, Cavallari M, Urso A, Rotondo F, Betulla A, Tognolo L, Bardi MA, Rossini M, Tammiso E, Bassi C, Cavazzini F, Negrini M, Cuneo A.

    08/7/2021
    Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline.

    Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline.
    Chen SD, Li HQ, Shen XN, Li JQ, Xu W, Huang YY, Tan L, Dong Q, Yu JT, Alzheimer’s Disease Neuroimaging Initiative.

    05/15/2021
    Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases.

    Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases.
    Magnusson L, Espes D, Casas R, Carlsson PO., Free PMC Article

    04/24/2021
    SLAMF1 signaling induces Mycobacterium tuberculosis uptake leading to endolysosomal maturation in human macrophages.

    SLAMF1 signaling induces Mycobacterium tuberculosis uptake leading to endolysosomal maturation in human macrophages.
    Barbero AM, Trotta A, Genoula M, Pino REHD, Estermann MA, Celano J, Fuentes F, García VE, Balboa L, Barrionuevo P, Pasquinelli V.

    03/20/2021
    Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species.

    Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species.
    Fukuhara H, Ito Y, Sako M, Kajikawa M, Yoshida K, Seki F, Mwaba MH, Hashiguchi T, Higashibata MA, Ose T, Kuroki K, Takeda M, Maenaka K., Free PMC Article

    08/29/2020
    the weak cis interaction of the H protein with SLAM on the same cell surface also could trigger hyperfusogenic F proteins. Some enveloped viruses may exploit such cis interactions with receptors to infect target cells, especially in cell-to-cell transmission.

    Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates.
    Shirogane Y, Hashiguchi T, Yanagi Y., Free PMC Article

    06/13/2020
    SLAMF1 ligation in a human peripheral blood T cell-B cell culture system reduced the following in both healthy controls and patients with SLE: conjugate formation, interleukin-6 (IL-6) production by B cells, IL-21 and IL-17A production by T cells, and Ig and autoantibody production.

    Signaling Lymphocytic Activation Molecule Family Member 1 Engagement Inhibits T Cell-B Cell Interaction and Diminishes Interleukin-6 Production and Plasmablast Differentiation in Systemic Lupus Erythematosus.
    Karampetsou MP, Comte D, Suárez-Fueyo A, Katsuyama E, Yoshida N, Kono M, Kyttaris VC, Tsokos GC., Free PMC Article

    11/2/2019
    SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.

    SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.
    Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T., Free PMC Article

    03/23/2019
    CD150 and CD180 receptors may modulate transcriptional program in lymphocytic leukemia cells by regulating the transcription factor expression levels

    CD150 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells.
    Gordiienko I, Shlapatska L, Kholodniuk VM, Kovalevska L, Ivanivskaya TS, Sidorenko SP.

    02/24/2018
    this paper shows that the X-linked lymphoproliferative disease gene product SAP regulates signals induced through the co-receptor SLAM

    Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469.
    Sayos J, Wu C, Morra M, Wang N, Zhang X, Allen D, van Schaik S, Notarangelo L, Geha R, Roncarolo MG, Oettgen H, De Vries JE, Aversa G, Terhorst C.

    02/17/2018
    combination of signals via CD150 and CD180 leads to blocking of pro-survival pathways that may be a restraining factor for neoplastic CLL B cells propagation in more than 50% of CLL cases where these receptors are coexpressed

    The interplay of CD150 and CD180 receptor pathways contribute to the pathobiology of chronic lymphocytic leukemia B cells by selective inhibition of Akt and MAPK signaling.
    Gordiienko I, Shlapatska L, Kholodniuk V, Sklyarenko L, Gluzman DF, Clark EA, Sidorenko SP., Free PMC Article

    11/4/2017
    EBF1 is critical for transcriptional control of SLAMF1 gene in human B cells.

    Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells.
    Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, Korneev KV, Dmitriev SE, Polanovsky OL, Sidorenko SP, Kulakovskiy IV, Kuprash DV.

    06/3/2017
    MeV can hijack SLAMF1 to drive endocytosis using a complex pathway that shares features with canonical viral macropinocytosis, phagocytosis, and mechanotransduction. This uptake pathway is specific to SLAMF1-positive cells and occurs within 60 min of viral attachment.

    The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis.
    Gonçalves-Carneiro D, McKeating JA, Bailey D., Free PMC Article

    05/20/2017
    Malignant B-cell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform.

    Differential expression of CD150/SLAMF1 in normal and malignant B cells on the different stages of maturation.
    Gordiienko IM, Shlapatska LM, Kovalevska LM, Sidorenko SP.

    04/8/2017
    Data suggest that SLAMF1 is another significant piece in the intricate defective immune-regulatory function of patients with SLE.

    Analysis of expression and function of the co-stimulatory receptor SLAMF1 in immune cells from patients with systemic lupus erythematosus (SLE).
    Liñán-Rico L, Hernández-Castro B, Doniz-Padilla L, Portillo-Salazar H, Baranda L, Cruz-Muñoz ME, González-Amaro R.

    07/30/2016
    results indicate that loss of SLAMF1 expression in chronic lymphocytic leukemia modulates genetic pathways

    SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response.
    Bologna C, Buonincontri R, Serra S, Vaisitti T, Audrito V, Brusa D, Pagnani A, Coscia M, D'Arena G, Mereu E, Piva R, Furman RR, Rossi D, Gaidano G, Terhorst C, Deaglio S., Free PMC Article

    06/28/2016
    Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150

    Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150.
    Putlyaeva LV, Schwartz AM, Korneev KV, Covic M, Uroshlev LA, Makeev VY, Dmitriev SE, Kuprash DV.

    10/17/2015
    Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM peptide.

    Structural characterization of disease-causing mutations on SAP and the functional impact on the SLAM peptide: a molecular dynamics approach.
    Chandrasekaran P, Rajasekaran R.

    01/31/2015
    Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

    Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.
    Menard L, Cantaert T, Chamberlain N, Tangye SG, Riminton S, Church JA, Klion A, Cunningham-Rundles C, Nichols KE, Meffre E., Free PMC Article

    06/21/2014
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