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    SIX1 SIX homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 6495, updated on 8-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC.

    Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC.
    Huang S, Hu J, Hu M, Hou Y, Zhang B, Liu J, Liu X, Chen Z, Wang L.

    10/1/2024
    BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.

    BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation.
    Zhang P, Zhang W, Wang X, Li L, Lin Y, Wu N, Mao R, Lin J, Kang M, Ding C.

    08/6/2024
    Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.

    Adipose Mesenchymal Stem Cell-derived Exosomes Enhanced Glycolysis through the SIX1/HBO1 Pathway against Oxygen and Glucose Deprivation Injury in Human Umbilical Vein Endothelial Cells.
    Zhang X, Zhang X, Chen L, Zhao J, Raj A, Wang Y, Li S, Zhang C, Yang J, Sun D.

    06/27/2024
    SIX1 amplification modulates stemness and tumorigenesis in breast cancer.

    SIX1 amplification modulates stemness and tumorigenesis in breast cancer.
    Guo L, Li F, Liu H, Kong D, Chen C, Sun S., Free PMC Article

    01/31/2024
    Altered binding affinity of SIX1-Q177R correlates with enhanced WNT5A and WNT pathway effector expression in Wilms tumor.

    Altered binding affinity of SIX1-Q177R correlates with enhanced WNT5A and WNT pathway effector expression in Wilms tumor.
    Stevenson MJ, Phanor SK, Patel U, Gisselbrecht SS, Bulyk ML, O'Brien LL., Free PMC Article

    11/22/2023
    Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea.

    Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea.
    Lee S, Yun Y, Cha JH, Han JH, Lee DH, Song JJ, Park MK, Lee JH, Oh SH, Choi BY, Lee SY., Free PMC Article

    10/26/2023
    [Effect of Inhibiting SIX1 Expression on Drug-resistance of Acute Myeloid Leukemia Cell Line HL-60/ADR Cells].

    [Effect of Inhibiting SIX1 Expression on Drug-resistance of Acute Myeloid Leukemia Cell Line HL-60/ADR Cells].
    Li LY, Nie ZY, Zhang XY, Luo JM, Yang L, Wang Q.

    08/9/2023
    Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children.

    Association of SIX1-SIX6 polymorphisms with peripapillary retinal nerve fibre layer thickness in children.
    Lu SY, Zhang XJ, Wang YM, Yuan N, Kam KW, Chan PP, Tam PO, Yip WW, Young AL, Tham CC, Pang CP, Yam JC, Chen LJ.

    07/27/2023
    FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression.

    FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression.
    Zou J, Huang Y, Chen Y, Wu Z, Xie H, Zhou H, Xing C.

    07/21/2023
    LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.

    LRRC75A-AS1 delivered by M2 macrophage exosomes promotes cervical cancer progression via enhancing SIX1 expression.
    Sui HY, Cui XY, Shi CX, Yan ZP, Li HC, Wang F., Free PMC Article

    06/7/2023
    The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.

    The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.
    Ge W, Meng L, Cao S, Hou C, Zhu X, Huang D, Li Q, Peng Y, Jiang K., Free PMC Article

    03/27/2023
    Lack of association between SIX1/SIX6 locus polymorphisms and pseudoexfoliation syndrome in a population from the Republic of Korea.

    Lack of association between SIX1/SIX6 locus polymorphisms and pseudoexfoliation syndrome in a population from the Republic of Korea.
    Lee YC, Lee MY, Shin HY., Free PMC Article

    01/11/2023
    Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis.

    Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of Intestinal Immune Homeostasis and Promotes Early-onset Fatal Spontaneous Colitis.
    Zhao YX, Mei H, Huang YX, Chen JQ.

    10/15/2022
    Association of Polymorphisms at the SIX1/SIX6 Locus With Normal Tension Glaucoma in a Korean Population.

    Association of Polymorphisms at the SIX1/SIX6 Locus With Normal Tension Glaucoma in a Korean Population.
    Shin HY, Lee YC, Lee MY.

    09/17/2022
    Homeoprotein SIX1 compromises antitumor immunity through TGF-beta-mediated regulation of collagens.

    Homeoprotein SIX1 compromises antitumor immunity through TGF-β-mediated regulation of collagens.
    Liu W, Gao M, Li L, Chen Y, Fan H, Cai Q, Shi Y, Pan C, Liu J, Cheng LS, Yang H, Cheng G., Free PMC Article

    04/9/2022
    Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1.

    Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1.
    Li Y, Ng EY, Loh YR, Gea CY, Huang Q, Li Q, Kang C.

    03/19/2022
    Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease.

    Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease.
    Coppenrath K, Tavares ALP, Shaidani NI, Wlizla M, Moody SA, Horb M., Free PMC Article

    03/19/2022
    Phenotype-genotype correlation in patients with typical and atypical branchio-oto-renal syndrome.

    Phenotype-genotype correlation in patients with typical and atypical branchio-oto-renal syndrome.
    Masuda M, Kanno A, Nara K, Mutai H, Morisada N, Iijima K, Morimoto N, Nakano A, Sugiuchi T, Okamoto Y, Masuda S, Katsunuma S, Ogawa K, Matsunaga T., Free PMC Article

    03/5/2022
    Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders.

    Unexpected role of SIX1 variants in craniosynostosis: expanding the phenotype of SIX1-related disorders.
    Calpena E, Wurmser M, McGowan SJ, Atique R, Bertola DR, Cunningham ML, Gustafson JA, Johnson D, Morton JEV, Passos-Bueno MR, Timberlake AT, Lifton RP, Wall SA, Twigg SRF, Maire P, Wilkie AOM., Free PMC Article

    03/5/2022
    Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.

    Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.
    Ciceri S, Montalvão-de-Azevedo R, Tajbakhsh A, Bertolotti A, Spagnuolo RD, Boschetti L, Capasso M, D'Angelo P, Serra A, Diomedi-Camassei F, Meli M, Nantron M, Quarello P, Buccoliero AM, Tamburini A, Ciniselli CM, Verderio P, Collini P, Radice P, Spreafico F, Perotti D.

    02/26/2022
    Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-kappaB axis promotes proliferation and migration in breast cancer.

    Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590-3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer.
    Chang J, Zhang Y, Ye X, Guo H, Lu K, Liu Q, Guo Y., Free PMC Article

    02/19/2022
    A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.

    A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.
    Liao Y, Liu Y, Shao Z, Xia X, Deng Y, Cai J, Yao L, He J, Yu C, Hu T, Sun W, Liu F, Tang D, Liu J, Huang H.

    12/25/2021
    SIX1 transcription factor: A review of cellular functions and regulatory dynamics.

    SIX1 transcription factor: A review of cellular functions and regulatory dynamics.
    Rafiq A, Aashaq S, Jan I, Beigh MA.

    12/25/2021
    Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4alpha and SIX1/4.

    Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4.
    Camolotto SA, Belova VK, Torre-Healy L, Vahrenkamp JM, Berrett KC, Conway H, Shea J, Stubben C, Moffitt R, Gertz J, Snyder EL., Free PMC Article

    12/4/2021
    Silencing SIX1 inhibits epithelial mesenchymal transition through regulating TGF-beta/Smad2/3 signaling pathway in papillary thyroid carcinoma.

    Silencing SIX1 inhibits epithelial mesenchymal transition through regulating TGF-β/Smad2/3 signaling pathway in papillary thyroid carcinoma.
    Min WP, Wei XF.

    11/13/2021
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