| In summary, CENP-H may be involved in cell proliferation and apoptosis of hepatocellular carcinoma (HCC)cells through the mitochondrial apoptotic pathway. Combined with previous studies, the data provide a new perspective on HCC development and progression. | CENP-H regulates the cell growth of human hepatocellular carcinoma cells through the mitochondrial apoptotic pathway.
Lu G, Hou H, Lu X, Ke X, Wang X, Zhang D, Zhao Y, Zhang J, Ren M, He S. | 03/3/2018 |
| Upregulation of centromere protein H is associated with progression of renal cell carcinoma | Upregulation of centromere protein H is associated with progression of renal cell carcinoma.
Wu X, Lin Y, Shi L, Huang Y, Lai C, Wang Y, Zhang M, Wang S, Heng B, Yu G, Du X, Fang L, Fu Y, Chen J, Guo Z, Su Z, Wu S. | 05/28/2016 |
| propose that CSPP1 cooperates with CENP-H on kinetochores to serve as a novel regulator of kinetochore microtubule dynamics for accurate chromosome segregation | Mitotic Protein CSPP1 Interacts with CENP-H Protein to Coordinate Accurate Chromosome Oscillation in Mitosis.
Zhu L, Wang Z, Wang W, Wang C, Hua S, Su Z, Brako L, Garcia-Barrio M, Ye M, Wei X, Zou H, Ding X, Liu L, Liu X, Yao X., Free PMC Article | 05/7/2016 |
| CENP-H was overexpressed in HCC, and its level of upregulation was an independent prognostic indicator, suggesting that CENP-H may be an effective therapeutic strategy for the treatment of HCC. | Overexpression of CENP-H as a novel prognostic biomarker for human hepatocellular carcinoma progression and patient survival.
Lu G, Shan T, He S, Ren M, Zhu M, Hu Y, Lu X, Zhang D. | 04/12/2014 |
| CENP-H promotes the proliferation of human gastric cancer cells | [Role of centromere protein H in human gastric cancer cell proliferation].
Quan T, He B, Liu T, Li W, Wu S, Jiang Q, Liu W, Liu H, Xu X. | 09/28/2013 |
| High expression of CENP-H in gastric cancer indicates poor prognosis and Survivin may mediate its procancer role. | Combined evaluation of centromere protein H and Ki-67 as prognostic biomarker for patients with gastric carcinoma.
He WL, Li YH, Yang DJ, Song W, Chen XL, Liu FK, Wang Z, Li W, Chen W, Chen CY, He YL, Zhan WH. | 03/2/2013 |
| Breast cancer patients with high CENP-H expression had short overall survival. CENP-H expression was related with clinical stage. | Overexpression of centromere protein H is significantly associated with breast cancer progression and overall patient survival.
Liao WT, Feng Y, Li ML, Liu GL, Li MZ, Zeng MS, Song LB., Free PMC Article | 12/8/2012 |
| upregulated CENP-H and Ki67 levels are significantly associated with short relapse-free survival in hypopharyngeal squamous cell carcinoma (HSSC); these factors may be predictors of a relapsing phenotype in HSSC cases | Role of centromere protein H and Ki67 in relapse-free survival of patients after primary surgery for hypopharyngeal cancer.
Wang JX, Zhang YY, Yu XM, Jin T, Pan XL. | 12/8/2012 |
| Sp1 and Sp3 bind to the CENPH minimal promoter and function as a regulator of the transcription of CENPH in nasopharyngeal carcinomas. | Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.
Zhao WF, Wang HB, Xie B, Hu LJ, Xu LH, Kuang BH, Li MZ, Zhang X. | 09/29/2012 |
| CENP-H-containing complex facilitates deposition of newly synthesized CENP-A into centromeric chromatin in cooperation with FACT and CHD1. | CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.
Okada M, Okawa K, Isobe T, Fukagawa T., Free PMC Article | 01/21/2010 |
| Upregulation of CENP-H in tongue cancer is associated with disease progression. | Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression.
Liao WT, Yu CP, Wu DH, Zhang L, Xu LH, Weng GX, Zeng MS, Song LB, Li JS., Free PMC Article | 01/21/2010 |
| expression of CENPH was much higher in cancer cell lines & lung cancer tissue than normal cells & adjacent noncancerous lung tissues; results show that high CENPH protein expression was related to poor outcome in patients with nonsmall cell lung cancer | Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival.
Liao WT, Wang X, Xu LH, Kong QL, Yu CP, Li MZ, Shi L, Zeng MS, Song LB. | 01/21/2010 |
| TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H. | TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression.
Miyajima N, Maruyama S, Nonomura K, Hatakeyama S. | 01/21/2010 |
| the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins. | KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.
Cheeseman IM, Hori T, Fukagawa T, Desai A., Free PMC Article | 01/21/2010 |
| CENP-H protein has a role in esophageal carcinoma progression | Prognostic relevance of Centromere protein H expression in esophageal carcinoma.
Guo XZ, Zhang G, Wang JY, Liu WL, Wang F, Dong JQ, Xu LH, Cao JY, Song LB, Zeng MS., Free PMC Article | 01/21/2010 |
| CENP-C and CENP-H co-localize to the CENP-A chromatin domain. | Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.
Alonso A, Fritz B, Hasson D, Abrusan G, Cheung F, Yoda K, Radlwimmer B, Ladurner AG, Warburton PE., Free PMC Article | 01/21/2010 |
| has an important impact on the architecture and function of the human kinetochore complex | RNAi knockdown of human kinetochore protein CENP-H.
Orthaus S, Ohndorf S, Diekmann S. | 01/21/2010 |
| CENP-H has a role in preventing progression of nasopharyngeal carcinoma | Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival.
Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, Feng Y, Guo BH, Mai HQ, Cao SM, Li MZ, Qin HD, Zeng YX, Zeng MS. | 01/21/2010 |
| The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres. | The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T. | 01/21/2010 |
| CENP-H is up-regulated and plays an important role in the aneuploidy frequently observed in colorectal cancers. | Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy.
Tomonaga T, Matsushita K, Ishibashi M, Nezu M, Shimada H, Ochiai T, Yoda K, Nomura F. | 01/21/2010 |