| Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization. | Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization.
Shamir M, Martin FJO, Woolfson DN, Friedler A., Free PMC Article | 11/7/2023 |
| STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer. | STIL/AURKA axis promotes cell proliferation by influencing primary cilia formation in bladder cancer.
Li J, Qi Y, Li B, Liu Y, Yang K, Zhang Z, Zhu J, Du E., Free PMC Article | 05/3/2023 |
| Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration. | Direct interaction between CEP85 and STIL mediates PLK4-driven directed cell migration.
Liu Y, Kim J, Philip R, Sridhar V, Chandrashekhar M, Moffat J, van Breugel M, Pelletier L., Free PMC Article | 08/28/2021 |
| circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426. | circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426.
Chen Z, Ling K, Zhu Y, Deng L, Li Y, Liang Z. | 07/3/2021 |
| Novel compound heterozygous variants in the STIL gene identified in a Chinese family with presentation of foetal microcephaly. | Novel compound heterozygous variants in the STIL gene identified in a Chinese family with presentation of foetal microcephaly.
Cheng C, Yang Y, Zhu X, Yu X, Zhang T, Yang F, Chen F, Chen X, Zhao S, Guo J. | 06/5/2021 |
| Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex. | Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
Ito H, Tsunoda T, Riku M, Inaguma S, Inoko A, Murakami H, Ikeda H, Matsuda M, Kasai K. | 11/28/2020 |
| Knockdown of STIL suppresses the progression of gastric cancer by down-regulating the IGF-1/PI3K/AKT pathway. | Knockdown of STIL suppresses the progression of gastric cancer by down-regulating the IGF-1/PI3K/AKT pathway.
Wang J, Zhang Y, Dou Z, Jiang H, Wang Y, Gao X, Xin X., Free PMC Article | 08/29/2020 |
| these results demonstrate that SFI1 is a centrosomal protein that localizes USP9X to the centrosome to stabilize STIL and promote centriole duplication. We propose that the USP9X protection of STIL to facilitate centriole duplication underlies roles of both proteins in human neurodevelopment. | SFI1 promotes centriole duplication by recruiting USP9X to stabilize the microcephaly protein STIL.
Kodani A, Moyer T, Chen A, Holland A, Walsh CA, Reiter JF., Free PMC Article | 05/16/2020 |
| STIL is a key regulator that promotes the proliferation of nasopharyngeal carcinoma | STIL is upregulated in nasopharyngeal carcinoma tissues and promotes nasopharyngeal carcinoma proliferation, migration and invasion.
Ouyang Y, Jin YB, Chen XP, Zhang GY, Mao SL, Ling F, Luo W. | 03/14/2020 |
| The conserved short coiled-coil region of STIL binds to and protects Plk4 from protein degradation at the site of procentriole formation. On the other hand, the conserved C-terminal region of STIL named truncated in microcephaly (TIM) domain promotes autophosphorylation and degradation of adjacent Plk4 by the direct interaction. | Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number.
Ohta M, Watanabe K, Ashikawa T, Nozaki Y, Yoshiba S, Kimura A, Kitagawa D. | 11/9/2019 |
| blocking of PLK4 or STIL functions leads to centrosome loss followed by both p53-dependent and -independent defects, including prolonged cell divisions, upregulation of p53, chromosome instability, and, importantly, reduction of pluripotency markers and induction of differentiation. | Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells.
Renzova T, Bohaciakova D, Esner M, Pospisilova V, Barta T, Hampl A, Cajanek L., Free PMC Article | 09/21/2019 |
| suggesting that STIL-TAL1 fusion genes are most probably postnatal events in paediatric T-cell acute lymphoblastic leukaemia | Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
Gustafsson BM, Mattsson K, Bogdanovic G, Leijonhufvud G, Honkaniemi E, Ramme K, Ford AM. | 05/25/2019 |
| Data describe a novel mechanism that contributes to centriole homeostasis in human cells by controlling the abundance and localization of the centriole duplication factor STIL which was identified as a direct target of bTrCP. bTrCP binds aDSG motif located within the N-terminus of STIL, and that mutation of this degron leads to STIL stabilization and consequent centriole overduplication. | The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.
Arquint C, Cubizolles F, Morand A, Schmidt A, Nigg EA., Free PMC Article | 03/16/2019 |
| Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly. | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Liu Y, Gupta GD, Barnabas DD, Agircan FG, Mehmood S, Wu D, Coyaud E, Johnson CM, McLaughlin SH, Andreeva A, Freund SMV, Robinson CV, Cheung SWT, Raught B, Pelletier L, van Breugel M., Free PMC Article | 12/22/2018 |
| Results from a study on gene expression variability markers in early-stage human embryos shows that STIL is a putative expression variability marker for the 3-day, 8-cell embryo stage. | Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article | 07/23/2018 |
| we observed that depletion of STIL enhanced canonical homologous recombination repair and increased BRCA1 and RAD51 foci in response to DNA double strand breaks. Thus, inhibition of STIL significantly enhances the efficacy of DNA damaging chemotherapeutic drugs in treatment of ovarian cancer. | Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer.
Rabinowicz N, Mangala LS, Brown KR, Checa-Rodriguez C, Castiel A, Moskovich O, Zarfati G, Trakhtenbrot L, Levy-Barda A, Jiang D, Rodriguez-Aguayo C, Pradeep S, van Praag Y, Lopez-Berestein G, David A, Novikov I, Huertas P, Rottapel R, Sood AK, Izraeli S., Free PMC Article | 03/10/2018 |
| These data show that complementary mechanisms, such as mother-daughter centriole proximity and CDK1-CyclinB interaction with centriolar components, ensure that centriole biogenesis occurs once and only once per cell cycle, raising parallels to the cell-cycle regulation of DNA replication and centromere formation. | CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis.
Zitouni S, Francia ME, Leal F, Montenegro Gouveia S, Nabais C, Duarte P, Gilberto S, Brito D, Moyer T, Kandels-Lewis S, Ohta M, Kitagawa D, Holland AJ, Karsenti E, Lorca T, Lince-Faria M, Bettencourt-Dias M., Free PMC Article | 01/27/2018 |
| RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. | Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Chen HY, Wu CT, Tang CC, Lin YN, Wang WJ, Tang TK., Free PMC Article | 12/16/2017 |
| Deletions of Stil is associated with acute T-lymphoblastic leukemia. | Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis.
Skalska-Sadowska J, Dawidowska M, Szarzyńska-Zawadzka B, Jarmuż-Szymczak M, Czerwińska-Rybak J, Machowska L, Derwich K. | 07/22/2017 |
| Studies indicate that depletion of any one of the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification. | The PLK4-STIL-SAS-6 module at the core of centriole duplication.
Arquint C, Nigg EA., Free PMC Article | 07/15/2017 |
| Reconstituting mouse embryonic fibroblasts lacking endogenous Stil, the authors show that STIL oligomerization mediated by these residues is not only important for the centrosomal functions of STIL during the canonical duplication process but also for de-novo formation of centrosomes. | Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.
David A, Amartely H, Rabinowicz N, Shamir M, Friedler A, Izraeli S., Free PMC Article | 03/4/2017 |
| Egyptian T-cell acute lymphoblastic leukemia cases seemed to have a different genetic pattern compared to other populations, with a lower incidence of TLX3/HOX11L2 and SIL/TAL but a higher incidence of NKX2-5 expression than recorded in Western countries | NKX2-5, SIL/TAL and TLX3/HOX11L2 expression in Egyptian pediatric T-cell acute lymphoblastic leukemia.
Moussa H, Sidhom I. | 11/12/2016 |
| data provide evidence for novel functions of the human oncogene Stil in neural toxic susceptibility. | A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway.
Li L, Carr AL, Sun L, Drewing A, Lee J, Rao Z., Free PMC Article | 09/10/2016 |
| The authors suggest that the STIL-coiled-coil region/PLK4 interaction mediates PLK4 activation as well as stabilization of centriolar PLK4 and plays a key role in centriole duplication. | STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Arquint C, Gabryjonczyk AM, Imseng S, Böhm R, Sauer E, Hiller S, Nigg EA, Maier T., Free PMC Article | 04/16/2016 |
| The STIL p.Gly717Glu mutation was not able to fully restore the centriole duplication failure following depletion of endogenous STIL protein indicating the deleterious role of the mutation. | Homozygous STIL mutation causes holoprosencephaly and microcephaly in two siblings.
Mouden C, de Tayrac M, Dubourg C, Rose S, Carré W, Hamdi-Rozé H, Babron MC, Akloul L, Héron-Longe B, Odent S, Dupé V, Giet R, David V., Free PMC Article | 02/6/2016 |