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    ST6GAL1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 6480, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.

    Evaluation of ST6Gal1 expression and clinicopathological significance in human glioma.
    Zhou Y, Wu Y, Shen D, Wang Q, Thomas AM, Li S, Shi F, Lam EW, Qin H.

    10/4/2024
    N-linked alpha2,6-sialylation of integrin beta1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.

    N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease.
    Liu J, Dong X, Xie R, Tang Y, Thomas AM, Li S, Liu S, Yu M, Qin H.

    04/12/2024
    ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.

    ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression.
    Bhalerao N, Chakraborty A, Marciel MP, Hwang J, Britain CM, Silva AD, Eltoum IE, Jones RB, Alexander KL, Smythies LE, Smith PD, Crossman DK, Crowley MR, Shin B, Harrington LE, Yan Z, Bethea MM, Hunter CS, Klug CA, Buchsbaum DJ, Bellis SL., Free PMC Article

    03/20/2024
    CCCTC-binding factor: the specific transcription factor of beta-galactoside alpha-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.

    CCCTC-binding factor: the specific transcription factor of β-galactoside α-2,6-sialyltransferase 1 that upregulates the sialylation of anti-citrullinated protein antibodies in rheumatoid arthritis.
    Zhao H, Wang H, Qin Y, Ling S, Zhai H, Jin J, Fang L, Cao Z, Jin S, Yang X, Wang J.

    03/5/2024
    Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics.

    Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics.
    Ankenbauer KE, Rao TC, Mattheyses AL, Bellis SL., Free PMC Article

    02/6/2024
    Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.

    Role of ST6GAL1 in Thyroid Cancers: Insights from Tissue Analysis and Genomic Datasets.
    Gunjača I, Benzon B, Pleić N, Babić Leko M, Pešutić Pisac V, Barić A, Kaličanin D, Punda A, Polašek O, Vukojević K, Zemunik T., Free PMC Article

    11/28/2023
    Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.

    Role of the ST6GAL1 sialyltransferase in regulating ovarian cancer cell metabolism.
    Jones RB, Silva AD, Ankenbauer KE, Britain CM, Chakraborty A, Brown JA, Ballinger SW, Bellis SL., Free PMC Article

    10/26/2023
    ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.

    ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression.
    Scott E, Archer Goode E, Garnham R, Hodgson K, Orozco-Moreno M, Turner H, Livermore K, Putri Nangkana K, Frame FM, Bermudez A, Jose Garcia Marques F, McClurg UL, Wilson L, Thomas H, Buskin A, Hepburn A, Duxfield A, Bastian K, Pye H, Arredondo HM, Hysenaj G, Heavey S, Stopka-Farooqui U, Haider A, Freeman A, Singh S, Johnston EW, Punwani S, Knight B, McCullagh P, McGrath J, Crundwell M, Harries L, Heer R, Maitland NJ, Whitaker H, Pitteri S, Troyer DA, Wang N, Elliott DJ, Drake RR, Munkley J.

    09/21/2023
    ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.

    ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
    Zou X, Lu J, Deng Y, Liu Q, Yan X, Cui Y, Xiao X, Fang M, Yang F, Sawaki H, Sato T, Tan B, Lu X, Feng B, Kuno A, Narimatsu H, Gao C, Zhang Y.

    02/15/2023
    Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.

    Role of ST6GAL1 and ST6GAL2 in subversion of cellular signaling during enteroaggregative Escherichia coli infection of human intestinal epithelial cell lines.
    Chandel S, Joon A, Kaur S, Ghosh S., Free PMC Article

    02/10/2023
    Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness.

    Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness.
    Hait NC, Maiti A, Wu R, Andersen VL, Hsu CC, Wu Y, Chapla DG, Takabe K, Rusiniak ME, Bshara W, Zhang J, Moremen KW, Lau JTY., Free PMC Article

    11/19/2022
    Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome.

    Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome.
    Watts K, Wills C, Madi A, Palles C, Maughan TS, Kaplan R, Al-Tassan NA, Kerr R, Kerr DJ, Houlston RS, Escott-Price V, Cheadle JP., Free PMC Article

    07/30/2022
    Extracellular ST6GAL1 regulates monocyte-macrophage development and survival.

    Extracellular ST6GAL1 regulates monocyte-macrophage development and survival.
    Rusiniak ME, Punch PR, Hait NC, Maiti A, Burns RT, Chapla D, Moremen KW, Zhao P, Wells L, Hoffmeister K, Lau JTY., Free PMC Article

    07/23/2022
    ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion.

    ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion.
    Rao TC, Beggs RR, Ankenbauer KE, Hwang J, Ma VP, Salaita K, Bellis SL, Mattheyses AL., Free PMC Article

    05/7/2022
    Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer.

    Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer.
    Smithson M, Irwin R, Williams G, Alexander KL, Smythies LE, Nearing M, McLeod MC, Al Diffalha S, Bellis SL, Hardiman KM., Free PMC Article

    04/30/2022
    Regulation of ST6GAL1 sialyltransferase expression in cancer cells.

    Regulation of ST6GAL1 sialyltransferase expression in cancer cells.
    Dorsett KA, Marciel MP, Hwang J, Ankenbauer KE, Bhalerao N, Bellis SL., Free PMC Article

    03/19/2022
    ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab.

    ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab.
    Duarte HO, Rodrigues JG, Gomes C, Hensbergen PJ, Ederveen ALH, de Ru AH, Mereiter S, Polónia A, Fernandes E, Ferreira JA, van Veelen PA, Santos LL, Wuhrer M, Gomes J, Reis CA., Free PMC Article

    01/22/2022
    ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma.

    ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma.
    Myojin Y, Kodama T, Maesaka K, Motooka D, Sato Y, Tanaka S, Abe Y, Ohkawa K, Mita E, Hayashi Y, Hikita H, Sakamori R, Tatsumi T, Taguchi A, Eguchi H, Takehara T.

    01/22/2022
    ST6GAL1 and alpha2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.

    ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
    Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW., Free PMC Article

    12/18/2021
    ST6GAL1 polymorphisms influence susceptibility and progression of IgA nephropathy in a Chinese Han population.

    ST6GAL1 polymorphisms influence susceptibility and progression of IgA nephropathy in a Chinese Han population.
    Fu D, Zhong Z, Shi D, Peng Y, Li B, Wang D, Guo L, Li Z, Mao H, Yu X, Li M.

    10/23/2021
    Unliganded and CMP-Neu5Ac bound structures of human alpha-2,6-sialyltransferase ST6Gal I at high resolution.

    Unliganded and CMP-Neu5Ac bound structures of human α-2,6-sialyltransferase ST6Gal I at high resolution.
    Harrus D, Harduin-Lepers A, Glumoff T.

    10/16/2021
    Regulation of human beta-galactoside alpha2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells.

    Regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene expression during differentiation of human osteoblastic MG-63 cells.
    An SY, Lee M, Yoon HK, Abekura F, Kim KS, Kim DH, Kim HJ, Lee K, Kim CH, Lee YC.

    10/2/2021
    Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.

    Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells.
    Britain CM, Bhalerao N, Silva AD, Chakraborty A, Buchsbaum DJ, Crowley MR, Crossman DK, Edwards YJK, Bellis SL., Free PMC Article

    08/28/2021
    Nglycosylation and receptor tyrosine kinase signaling affect claudin3 levels in colorectal cancer cells.

    N‑glycosylation and receptor tyrosine kinase signaling affect claudin‑3 levels in colorectal cancer cells.
    Pérez AG, Andrade-Da-Costa J, De Souza WF, De Souza Ferreira M, Boroni M, De Oliveira IM, Freire-Neto CA, Fernandes PV, De Lanna CA, Souza-Santos PT, Morgado-Díaz JA, De-Freitas-Junior JCM., Free PMC Article

    07/10/2021
    Influences of two significant variants located in the ST6GAL1 3'-untranslated region on lung carcinoma susceptibility in the Chinese Han population.

    Influences of two significant variants located in the ST6GAL1 3'-untranslated region on lung carcinoma susceptibility in the Chinese Han population.
    Liu X, Chen L, Ren Z, Tian X.

    06/19/2021
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