| PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer. | PUM1 Promotes Tumor Progression by Activating DEPTOR-Meditated Glycolysis in Gastric Cancer.
Yin S, Liu H, Zhou Z, Xu X, Wang P, Chen W, Deng G, Wang H, Yu H, Gu L, Huo M, Li M, Zeng L, He Y, Zhang C., Free PMC Article | 09/28/2023 |
| DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells. | DEPTOR as a novel prognostic marker inhibits the proliferation via deactivating mTOR signaling pathway in gastric cancer cells.
Ma G, Sun Y, Cai F, Zhang M, Liang H, Deng J, Zhang R, Zhang L. | 04/28/2023 |
| The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells. | The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.
Zhang S, You X, Zheng Y, Shen Y, Xiong X, Sun Y., Free PMC Article | 03/7/2023 |
| DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR. | DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR.
Guo J, Yu J, Mu M, Chen Z, Xu Z, Zhao C, Yang K, Zheng J, Qin X, Zhao W, Sun X., Free PMC Article | 10/8/2022 |
| Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation. | Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.
Vega M, Chen Y, Shi Y, Gera J, Lichtenstein A., Free PMC Article | 05/7/2022 |
| Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis. | Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis.
Serrano-Maciá M, Simón J, González-Rellan MJ, Azkargorta M, Goikoetxea-Usandizaga N, Lopitz-Otsoa F, De Urturi DS, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gomez M, Gutiérrez de Juan V, Bizkarguenaga M, Fernández-Ramos D, Buque X, Baselli GA, Valenti LVC, Iruzubieta P, Crespo J, Villa E, Banales JM, Avila MA, Marin JJG, Aspichueta P, Sutherland J, Barrio R, Mayor U, Elortza F, Xirodimas DP, Nogueiras R, Delgado TC, Martínez-Chantar ML., Free PMC Article | 03/26/2022 |
| Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. | Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Cho JH, Kim K, Kim SA, Park S, Park BO, Kim JH, Kim SY, Kwon MJ, Han MH, Lee SB, Park BC, Park SG, Kim JH, Kim S., Free PMC Article | 01/22/2022 |
| DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals. | DEPTOR inhibits lung tumorigenesis by inactivating the EGFR-mTOR signals.
Gong L, Shu J, Chen X, Pan H, Chen G, Bi Y, Cui D, Li X, Liu D, Wang L, Wang Y, Liu P, Xiong X, Zhao Y. | 01/8/2022 |
| Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling. | Tyrosine phosphorylation of DEPTOR functions as a molecular switch to activate mTOR signaling.
M Gagné L, Morin N, Lavoie N, Bisson N, Lambert JP, Mallette FA, Huot MÉ., Free PMC Article | 12/18/2021 |
| Regulation of human mTOR complexes by DEPTOR. | Regulation of human mTOR complexes by DEPTOR.
Wälchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T., Free PMC Article | 10/30/2021 |
| Insights into DEPTOR regulation from in silico analysis of DEPTOR complexes. | Insights into DEPTOR regulation from in silico analysis of DEPTOR complexes.
Teh AH, Yeap KH, Hisano T. | 10/16/2021 |
| Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells. | Nuclear ErbB2 represses DEPTOR transcription to inhibit autophagy in breast cancer cells.
Bi Y, Gong L, Liu P, Xiong X, Zhao Y., Free PMC Article | 09/18/2021 |
| Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains. | Structural Basis of DEPTOR to Recognize Phosphatidic Acid Using its Tandem DEP Domains.
Weng Z, Shen X, Zheng J, Liang H, Liu Y. | 09/4/2021 |
| DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. | DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells.
Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, Xiong X, Zhao Y., Free PMC Article | 07/31/2021 |
| Regulatory role of DEPTORmediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma. | Regulatory role of DEPTOR‑mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma.
Wang J, Chen J, Qiu D, Zeng Z., Free PMC Article | 07/17/2021 |
| Function of Deptor and its roles in hematological malignancies. | Function of Deptor and its roles in hematological malignancies.
Morales-Martinez M, Lichtenstein A, Vega MI., Free PMC Article | 05/8/2021 |
| DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity. | DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity.
Cui D, Dai X, Gong L, Chen X, Wang L, Xiong X, Zhao Y., Free PMC Article | 05/1/2021 |
| DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells. | DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells.
Jabłońska E, Białopiotrowicz E, Szydłowski M, Prochorec-Sobieszek M, Juszczyński P, Szumera-Ciećkiewicz A. | 12/12/2020 |
| DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. | DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals.
Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, Shu J, Bi Y, Dai X, Gong L, Sun Y, Zhao Y., Free PMC Article | 11/28/2020 |
| Mechanistically, DEPTOR inhibited both mTOR Complex 1 (mTORC1) and 2 (mTORC2) activities in PA cells. In addition, DEPTOR expression level was increased to suppress mTOR kinase activity via decreasing E3 ubiquitin ligase, betaTrCP1, in response to CAB. | DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma.
Yao H, Tang H, Zhang Y, Zhang QF, Liu XY, Liu YT, Gu WT, Zheng YZ, Shang HB, Wang Y, Huang JY, Wei YX, Zhang X, Zhang J, Wu ZB. | 06/13/2020 |
| We identified and replicated three new genome-wide significant signals of association with idiopathic pulmonary fibrosissusceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR). The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis. | Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Allen RJ, Guillen-Guio B, Oldham JM, Ma SF, Dressen A, Paynton ML, Kraven LM, Obeidat M, Li X, Ng M, Braybrooke R, Molina-Molina M, Hobbs BD, Putman RK, Sakornsakolpat P, Booth HL, Fahy WA, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Whyte MKB, Zhang Y, Kaminski N, Adegunsoye A, Strek ME, Neighbors M, Sheng XR, Gudmundsson G, Gudnason V, Hatabu H, Lederer DJ, Manichaikul A, Newell JD Jr, O'Connor GT, Ortega VE, Xu H, Fingerlin TE, Bossé Y, Hao K, Joubert P, Nickle DC, Sin DD, Timens W, Furniss D, Morris AP, Zondervan KT, Hall IP, Sayers I, Tobin MD, Maher TM, Cho MH, Hunninghake GM, Schwartz DA, Yaspan BL, Molyneaux PL, Flores C, Noth I, Jenkins RG, Wain LV., Free PMC Article | 05/23/2020 |
| The role of DEPTOR polymorphism in T2D vascular complication. | DEPTOR polymorphisms influence late complications in Type 2 diabetes patients.
Klen J, Goričar K, Horvat S, Stojan J, Dolžan V. | 05/9/2020 |
| These findings may provide valuable molecular information for improving venous permeability through manipulation of DEPTOR and related mTOR pathways. | Identification and Analysis of Differentially Expressed Genes in Human Saphenous Vein Endothelial Cells Overexpressing Domain-Containing mTOR-Interacting Protein (DEPTOR) by RNA-Seq.
Wang W, Li Y, Wang Q, Cao Y, Wang F, Li W., Free PMC Article | 02/15/2020 |
| Data found that DEPTOR was frequently overexpressed in hepatocellular carcinoma (HCC) tissues, and its high expression was associated with high serum AFP levels, increased tumor size, vascular invasion and more advanced TMN and BCLC stage, as well as an overall poor prognosis. DEPTOR promotes the EMT and metastasis of HCC cells by activating the TGF-beta1-smad3/smad4-snail pathway via mTOR inhibition. | DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma.
Chen J, Zhu H, Liu Q, Ning D, Zhang Z, Zhang L, Mo J, Du P, Liu X, Song S, Fan Y, Liang H, Liu J, Zhang B, Chen X., Free PMC Article | 12/7/2019 |
| TNFAIP3-DEPTOR complex-induced early-onset autophagy is vital for immune inhibition in autoimmune disease. | TNFAIP3-DEPTOR complex regulates inflammasome secretion through autophagy in ankylosing spondylitis monocytes.
Zhai Y, Lin P, Feng Z, Lu H, Han Q, Chen J, Zhang Y, He Q, Nan G, Luo X, Wang B, Feng F, Liu F, Chen Z, Zhu P., Free PMC Article | 10/19/2019 |