| Regulatory mechanism of RNA binding motif protein 15-mediated N[6] methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells. | Regulatory mechanism of RNA binding motif protein 15-mediated N(6) methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells.
Chen J. | 10/25/2023 |
| RBM15-mediating MDR1 mRNA m[6]A methylation regulated by the TGF-beta signaling pathway in paclitaxel-resistant ovarian cancer. | RBM15‑mediating MDR1 mRNA m(6)A methylation regulated by the TGF‑β signaling pathway in paclitaxel‑resistant ovarian cancer.
Yuan J, Guan W, Li X, Wang F, Liu H, Xu G., Free PMC Article | 08/22/2023 |
| RBM15 m[6] A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling. | RBM15 m(6) A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling.
Song Y, Wu Q. | 08/9/2023 |
| Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer. | Knockdown of RBM15 inhibits tumor progression and the JAK-STAT signaling pathway in cervical cancer.
Zhang C, Gu L, Xiao J, Jin F., Free PMC Article | 07/27/2023 |
| RBM15 silencing promotes ferroptosis by regulating the TGF-beta/Smad2 pathway in lung cancer. | RBM15 silencing promotes ferroptosis by regulating the TGF-β/Smad2 pathway in lung cancer.
Feng J, Li Y, He F, Zhang F. | 03/15/2023 |
| Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA. | Knockdown RBM15 Inhibits Colorectal Cancer Cell Proliferation and Metastasis Via N6-Methyladenosine (m6A) Modification of MyD88 mRNA.
Zhang Z, Mei Y, Hou M. | 12/24/2022 |
| The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma. | The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma.
Ma M, Wang W, Wang B, Yang Y, Huang Y, Zhao G, Ye L. | 07/16/2022 |
| Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11. | Epigenetic activation of RBM15 promotes clear cell renal cell carcinoma growth, metastasis and macrophage infiltration by regulating the m6A modification of CXCL11.
Zeng X, Chen K, Li L, Tian J, Ruan W, Hu Z, Peng D, Chen Z. | 05/21/2022 |
| RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent. | RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent.
Wang X, Tian L, Li Y, Wang J, Yan B, Yang L, Li Q, Zhao R, Liu M, Wang P, Sun Y., Free PMC Article | 10/23/2021 |
| RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes. | RBM15-mediated N6-methyladenosine modification affects COVID-19 severity by regulating the expression of multitarget genes.
Meng Y, Zhang Q, Wang K, Zhang X, Yang R, Bi K, Chen W, Diao H., Free PMC Article | 08/7/2021 |
| Study has shown that MED12 mutations can be heterogeneous in both synchronous and recurrent phyllodes tumor unlike TERT mutations. Authors have also shown that RBM15 mutations may be important in the pathogenesis of borderline/malignant phyllodes tumors. | MED12, TERT promoter and RBM15 mutations in primary and recurrent phyllodes tumours.
Garcia-Dios DA, Levi D, Shah V, Gillett C, Simpson MA, Hanby A, Tomlinson I, Sawyer EJ., Free PMC Article | 01/19/2019 |
| The authors demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4). | Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, Laha S, Abdel-Wahab O, Levine RL, Raffel G, Liu Y, Chen D, Li H, Townes T, Wang H, Deng H, Zheng YG, Leslie C, Luo M, Zhao X., Free PMC Article | 10/29/2016 |
| OTT1 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thrombopoietin-mediated signaling. | Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Xiao N, Laha S, Das SP, Morlock K, Jesneck JL, Raffel GD., Free PMC Article | 04/25/2015 |
| RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment. | Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells.
Yang Y, Wang S, Zhang Y, Zhu X. | 06/22/2013 |
| both Rbm15 and the leukemogenic Rbm15-Mkl1 fusion protein interact with the Setd1b histone H3-Lys4 methyltransferase | Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.
Lee JH, Skalnik DG., Free PMC Article | 02/2/2013 |
| A four-way variant translocation originating the RBM15-MKL1 fusion gene is associated with acute megakaryoblastic leukemia. | Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene.
Torres L, Lisboa S, Vieira J, Cerveira N, Santos J, Pinheiro M, Correia C, Bizarro S, Almeida M, Teixeira MR. | 05/28/2011 |
| HHV-8 ORF57 interacts with RBM15 and OTT3 to promote expression of viral intronless genes. | Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.
Majerciak V, Uranishi H, Kruhlak M, Pilkington GR, Massimelli MJ, Bear J, Pavlakis GN, Felber BK, Zheng ZM., Free PMC Article | 03/12/2011 |
| The deregulated activation of MAL-dependent and -independent promoters results in tissue-specific functions of OTT-MAL.[OTT-MAL] | OTT-MAL is a deregulated activator of serum response factor-dependent gene expression.
Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, Bernard OA, Treisman R, Posern G., Free PMC Article | 01/21/2010 |
| functional and spatial changes of OTT and BSAC caused by the fusion might perturb their functions, culminating in the development of acute megakaryoblastic leukemia. | Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.
Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H., Free PMC Article | 01/21/2010 |
| Fusion with MKL1 protein in acute myeloid leukemi. | RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient.
Hsiao HH, Yang MY, Liu YC, Hsiao HP, Tseng SB, Chao MC, Liu TC, Lin SF. | 01/21/2010 |