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    FNDC3B fibronectin type III domain containing 3B [ Homo sapiens (human) ]

    Gene ID: 64778, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.

    Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis.
    Wang Y, Kong Y, Yang Q, Zhong C, Zhou D., Free PMC Article

    04/16/2024
    circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.

    circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.
    Song D, Ye Z, Chen F, Zhan L, Sun X., Free PMC Article

    09/27/2023
    Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.

    Lack of Association of Polymorphism Located Upstream of ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi Origin.
    Kondkar AA, Sultan T, Azad TA, Osman EA, Almobarak FA, Lobo GP, Al-Obeidan SA., Free PMC Article

    03/30/2023
    Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.

    Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.
    Zeng Q, Ji X, Li X, Tian Y.

    02/11/2023
    m[6]A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.

    m(6)A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.
    Zeng W, Zhu JF, Guo J, Huang GJ, Ai LS, Zeng Y, Liao WJ., Free PMC Article

    12/17/2022
    Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.

    Integrated machine learning methods identify FNDC3B as a potential prognostic biomarker and correlated with immune infiltrates in glioma.
    Wang X, Huang Y, Li S, Zhang H., Free PMC Article

    10/29/2022
    Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.

    Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.
    Chen X, Kong D, Deng J, Mo F, Liang J.

    10/15/2022
    Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.

    Long Non-Coding RNA DUXAP8 Acts as an Oncogene in Sinonasal Squamous Cell Carcinoma Through miR-584-5p/FNDC3B Pathway.
    Chen X, Li G, Zhong G, Chen J, Feng L, Zhang T, Tang Z.

    10/15/2022
    Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.

    Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.
    Zhang J, Peng Y, Jiang S, Li J., Free PMC Article

    07/16/2022
    Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.

    Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells.
    Liu Y, Zhong Z, Xiao L, Li W, Wang Z, Duan Z, Li X.

    12/18/2021
    CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression.

    CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression.
    Zeng W, Liu Y, Li WT, Li Y, Zhu JF., Free PMC Article

    11/13/2021
    CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis.

    CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis.
    Li Y, Tang Y, Li Z, Hou G, Du X.

    09/11/2021
    Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-beta1.

    Novel lncRNA XLOC_032768 protects against renal tubular epithelial cells apoptosis in renal ischemia-reperfusion injury by regulating FNDC3B/TGF-β1.
    Zhou X, Li Y, Wu C, Yu W, Cheng F., Free PMC Article

    07/24/2021
    Association between hsa_circ_0006156 expression and incidence of gastric cancer.

    Association between hsa_circ_0006156 expression and incidence of gastric cancer.
    He YX, Ju H, Li N, Jiang YF, Zhao WJ, Song TT, Ren WH.

    05/22/2021
    MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B.

    MicroRNA-363-3p promote the development of acute myeloid leukemia with RUNX1 mutation by targeting SPRYD4 and FNDC3B.
    Chen Y, Chen S, Lu J, Yuan D, He L, Qin P, Tan H, Xu L., Free PMC Article

    05/22/2021
    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.

    The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
    Fucci C, Resnati M, Riva E, Perini T, Ruggieri E, Orfanelli U, Paradiso F, Cremasco F, Raimondi A, Pasqualetto E, Nuvolone M, Rampoldi L, Cenci S, Milan E.

    05/8/2021
    results suggested that the 3'-UTR shortening of FNDC3B mRNA mediated its overexpression in nasopharyngeal carcinoma and promoted its progression by targeting MYH9

    FNDC3B 3'-UTR shortening escapes from microRNA-mediated gene repression and promotes nasopharyngeal carcinoma progression.
    Li YQ, Chen Y, Xu YF, He QM, Yang XJ, Li YQ, Hong XH, Huang SY, Tang LL, Liu N., Free PMC Article

    06/20/2020
    Findings highlight a physiological role for circRNAs in cardiac repair and indicate that modulation of circFndc3b expression may represent a potential strategy to promote cardiac function and remodeling after MI.

    Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.
    Garikipati VNS, Verma SK, Cheng Z, Liang D, Truongcao MM, Cimini M, Yue Y, Huang G, Wang C, Benedict C, Tang Y, Mallaredy V, Ibetti J, Grisanti L, Schumacher SM, Gao E, Rajan S, Wilusz JE, Goukassian D, Houser SR, Koch WJ, Kishore R., Free PMC Article

    01/11/2020
    These findings demonstrate that FAD104 is a novel suppressor of TGF-beta signalling and represses TGF-beta-mediated EMT in cervical cancer cells.

    FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-β-mediated EMT in cervical cancer cells.
    Goto M, Osada S, Imagawa M, Nishizuka M., Free PMC Article

    07/13/2019
    we identified an invasion-related circFNDC3B that was downregulated in human BC tissues and cells, and we found that decreased circFNDC3B expression was associated with poor prognosis of BC patients.

    Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis.
    Liu H, Bi J, Dong W, Yang M, Shi J, Jiang N, Lin T, Huang J., Free PMC Article

    04/27/2019
    we found that knockdown of FNDC3B could suppress the migratory and invasive abilities of OTSCC cells. In addition, treating OTSCC cells with CoCl2 (a hypoxia mimetic agent) upregulated the mRNA and protein expression of FNDC3B via HIF-1alpha

    FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment.
    Zhong Z, Zhang H, Hong M, Sun C, Xu Y, Chen X, Gao C, He M, Liu W, Liang J.

    08/25/2018
    FNDC3B and ANXA2 expression correlate negatively with patient survival in hepatocellular carcinoma

    FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma.
    Lin CH, Lin YW, Chen YC, Liao CC, Jou YS, Hsu MT, Chen CF., Free PMC Article

    02/24/2018
    we report the first two patients with de novo 3q26.31 microdeletions. Both have dysmorphic features, consistent with the phenotypes seen in fndc3b-deficient mice in animal studies, which imply a critical role of FNDC3B in human craniofacial development.

    Two cases with de novo 3q26.31 microdeletion suggest a role for FNDC3B in human craniofacial development.
    Cao Y, Mitchell EB, Gorski JL, Hollinger C, Hoppman NL.

    10/28/2017
    findings together indicate that NS5ABP37 inhibits cancer cell proliferation and promotes apoptosis, by altering SREBP-dependent lipogenesis and cholesterogenesis in HepG2 and L02 cells and inducing oxidative stress and endoplasmic reticulum stress

    NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis.
    Feng S, Han M, Zhou L, Wang Q, Li Z, Li Y, Lu H, Liu T, Ma Y, Liu S, Cheng J., Free PMC Article

    03/11/2017
    MiR-129-5p could directly suppress FNDC3B.

    Potential mechanisms of microRNA-129-5p in inhibiting cell processes including viability, proliferation, migration and invasiveness of glioblastoma cells U87 through targeting FNDC3B.
    Xu H, Hu Y, Qiu W.

    02/25/2017
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