Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells.
Qiao Z, Li Y, Li S, Liu S, Cheng Y.

Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma.
Han T, Wang Y, Cheng M, Hu Q, Wan X, Huang M, Liu Y, Xun W, Xu J, Wang L, Luo R, Yuan Y, Wang K, Wang J., Free PMC Article

YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2.
Wu A, Wang X, Zhang F, Yang X, Quan Y, Dong J, Lai Y, Yang D, Sun J, Wang M.

The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer.
Shan Y, Liu D, Li Y, Wu C, Ye Y., Free PMC Article

NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2.
Zhang Y, Huang H, Liu P, Xie Y.

MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2.
Zhou J, Li P, Feng J, Wu Q, You S.

SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling.
Wang W, Wang M, Du T, Hou Z, You S, Zhang S, Ji M, Xue N, Chen X., Free PMC Article

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Liu Z, Fan M, Hou J, Pan S, Xu Y, Zhang H, Liu C, Hao X, Li X, Wang H., Free PMC Article

Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis.
Yang G, Tan J, Guo J, Wu Z, Zhan Q.

Induction of serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma.
Clark RA, Qiao J, Jacobson JC, Chung DH., Free PMC Article

SHMT2 promotes the tumorigenesis of renal cell carcinoma by regulating the m6A modification of PPAT.
Huo FC, Xie M, Zhu ZM, Zheng JN, Pei DS.

The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, Garcia-Bermudez J, Cho BK, Tam W, Kelleher NL, Socci N, Dogan A, De Stanchina E, Ciriello G, Green MR, Li S, Birsoy K, Melnick AM, Wendel HG., Free PMC Article

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression.
Cui X, Cui Y, Du T, Jiang X, Song C, Zhang S, Ma C, Liu Y, Ni Q, Gao Y, Wang G., Free PMC Article

Serine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2).
Zhang H, Che Y, Xuan B, Wu X, Li H., Free PMC Article

SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T., Free PMC Article

Interaction analysis of gene variants related to one-carbon metabolism with chronic hepatitis B infection in Chinese patients.
Sun YH, Gao J, Liu XD, Tang HW, Cao SL, Zhang JK, Wen PH, Wang ZH, Li J, Guo WZ, Zhang SJ.

The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Chen J, Na R, Xiao C, Wang X, Wang Y, Yan D, Song G, Liu X, Chen J, Lu H, Chen C, Tang H, Zhuang G, Fan G, Peng Z., Free PMC Article

Identification of SHMT2 as a Potential Prognostic Biomarker and Correlating with Immune Infiltrates in Lung Adenocarcinoma.
Luo L, Zheng Y, Lin Z, Li X, Li X, Li M, Cui L, Luo H., Free PMC Article

Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.
Nguyen TH, Vemu PL, Hoy GE, Boudjadi S, Chatterjee B, Shern JF, Khan J, Sun W, Barr FG., Free PMC Article

Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome.
García-Cazorla À, Verdura E, Juliá-Palacios N, Anderson EN, Goicoechea L, Planas-Serra L, Tsogtbaatar E, Dsouza NR, Schlüter A, Urreizti R, Tarnowski JM, Gavrilova RH, SHMT2 Working Group, Ruiz M, Rodríguez-Palmero A, Fourcade S, Cogné B, Besnard T, Vincent M, Bézieau S, Folmes CD, Zimmermann MT, Klee EW, Pandey UB, Artuch R, Cousin MA, Pujol A., Free PMC Article

Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting β-catenin degradation.
Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, Deng P, Wang H, Deng Q, Lin Y, Jie H, Zhang H, Zhang J, Peng Y, Zhang H, Zhou Z, Sun Q, Cen X, Zhao Y., Free PMC Article

BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling.
Rabl J., Free PMC Article

Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer.
Wang H, Chong T, Li BY, Chen XS, Zhen WB., Free PMC Article

Serine-dependent redox homeostasis regulates glioblastoma cell survival.
Engel AL, Lorenz NI, Klann K, Münch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL., Free PMC Article

High expression of SHMT2 is correlated with tumor progression and predicts poor prognosis in gastrointestinal tumors.
Liu Y, Yin C, Deng MM, Wang Q, He XQ, Li MT, Li CP, Wu H.