| Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1. | Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1.
Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzolà F. | 08/14/2024 |
| Serine hydroxymethyltransferase 1 promotes low-grade glioma progression by activating mTORC1 signaling. | Serine hydroxymethyltransferase 1 promotes low-grade glioma progression by activating mTORC1 signaling.
Gao Y, Jing N, Teng X, Wang Y. | 05/7/2023 |
| Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis. | Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis.
Yang QQ, Zhang Y, Yang J. | 05/7/2022 |
| Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. | Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.
Pikman Y, Ocasio-Martinez N, Alexe G, Dimitrov B, Kitara S, Diehl FF, Robichaud AL, Conway AS, Ross L, Su A, Ling F, Qi J, Roti G, Lewis CA, Puissant A, Vander Heiden MG, Stegmaier K., Free PMC Article | 02/19/2022 |
| The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke. | The association between serine hydroxymethyl transferase 1 gene hypermethylation and ischemic stroke.
Wang J, Gu J, Huang Y, Fang Y, Lin J., Free PMC Article | 12/18/2021 |
| Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability. | Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability.
Lee WD, Pirona AC, Sarvin B, Stern A, Nevo-Dinur K, Besser E, Sarvin N, Lagziel S, Mukha D, Raz S, Aizenshtein E, Shlomi T. | 12/4/2021 |
| The human cytosolic serine hydroxymethyltransferase /Deltaflap variant exhibited different catalytic properties in (6S)-tetrahydrofolate (THF)-dependent reactions compared with the WT but had similar activity in THF-independent aldol cleavage of beta-hydroxyamino acid. | A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release.
Ubonprasert S, Jaroensuk J, Pornthanakasem W, Kamonsutthipaijit N, Wongpituk P, Mee-Udorn P, Rungrotmongkol T, Ketchart O, Chitnumsub P, Leartsakulpanich U, Chaiyen P, Maenpuen S., Free PMC Article | 03/14/2020 |
| association of the variant rs1979277 (G > A) and nonsyndromic cleft lip with or without cleft palate in a Chilean population | A SHMT1 variant decreases the risk of nonsyndromic cleft lip with or without cleft palate in Chile.
Salamanca C, González-Hormazábal P, Recabarren AS, Recabarren PA, Pantoja R, Leiva N, Pardo R, Suazo J. | 01/25/2020 |
| The moonlighting RNA-binding activity of cytosolic SHMT contributes to control compartmentalization of serine metabolism. | The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G, Paone A, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F., Free PMC Article | 11/30/2019 |
| Characterized the serine hydroxymethyltransferase reaction catalyzed by SHMT1 and SHMT2, with a focus on pH dependence and substrate inhibition. SHMT2 maintains a pronounced tetrahydrofolate substrate inhibition even at the alkaline pH characteristic of the mitochondrial matrix, whereas with SHMT1 this is almost abolished. At this pH, SHMT2 also shows a catalytic efficiency that is much higher than that of SHMT1. | Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties.
Tramonti A, Nardella C, di Salvo ML, Barile A, Cutruzzolà F, Contestabile R. | 08/3/2019 |
| miR-218-5p suppresses the killing effect of natural killer cells to lung adenocarcinoma cells by targeting SHMT1. | MiR-218-5p Suppresses the Killing Effect of Natural Killer Cell to Lung Adenocarcinoma by Targeting SHMT1.
Yang Q, Li J, Hu Y, Tang X, Yu L, Dong L, Chen D., Free PMC Article | 07/20/2019 |
| genotypes TT (SHMT1 rs4925166), CC (ERG rs2836425), GG (MAZ rs34286592), and GG (SHMT1 rs1979277) had the highest negative association (protective effect) with multiple sclerosis | Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.
Nazari Mehrabani SZ, Shushizadeh MH, Abazari MF, Nouri Aleagha M, Ardalan A, Abdollahzadeh R, Azarnezhad A. | 06/29/2019 |
| Studied association of essential hypertension (EH) predisposition and methylation patterns in promoter region of serine hydroxymethyltransferase 1(SHMT1); found SHMT1 promoter hypermethylation increases risk of EH and is a possible biomarker for EH. | Serine hydroxymethyltransferase 1 promoter hypermethylation increases the risk of essential hypertension.
Xu G, Wang C, Ying X, Kong F, Ji H, Zhao J, Zhang X, Duan S, Han L, Li L., Free PMC Article | 05/4/2019 |
| regulatory role of SHMT1 in vascular calcification during conditions of hyperphosphatemia such as chronic kidney disease | Role of Cytosolic Serine Hydroxymethyl Transferase 1 (SHMT1) in Phosphate-Induced Vascular Smooth Muscle Cell Calcification.
Boehme B, Schelski N, Makridakis M, Henze L, Vlahou A, Lang F, Pieske B, Alesutan I, Voelkl J. | 11/24/2018 |
| Methylene tetrahydrofolate reductase (MTHFR) C677T, 5-methyltetrahydrofolate homocysteine methyltransferase (MTR) A2756G and 5- methyltetrahydrofolate homocysteine methyltransferase reductase (MTRR) A66G were shown to be positively associatiated with homocysteine, while nonvegetarian diet, serine hydroxymethyltransferase 1 (SHMT1) C1420T and TYMS 5'-UTR 28 bp tandem repeat exhibited negative association with homocysteine. | Neuro-fuzzy model of homocysteine metabolism.
Naushad SM, Rama Devi AR, Nivetha S, Lakshmitha G, Stanley AB, Hussain T, Kutala VK. | 08/4/2018 |
| The one-carbon donor formate generally rescues cells from SHMT inhibition, but paradoxically increases the inhibitor's cytotoxicity in diffuse large B-cell lymphoma (DLBCL); this effect is rooted in defective glycine uptake in DLBCL cell lines, rendering them uniquely dependent upon SHMT enzymatic activity to meet glycine demand. | Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD., Free PMC Article | 06/30/2018 |
| The present study, using both case-control and family-based triad approach is the first report to demonstrate parental association of SHMT1 C1420T variant in conferring NTD risk in the fetus. | Interaction between Maternal and Paternal SHMT1 C1420T Predisposes to Neural Tube Defects in the Fetus: Evidence from Case-Control and Family-Based Triad Approaches.
K Rebekah P, Tella S, Buragadda S, Tiruvatturu MK, Akka J. | 04/21/2018 |
| SHMT1 controls the expression of pro-oncogenic inflammatory cytokines by regulating sialic acid Neu5Ac to promote ovarian cancer tumor growth and migration. | Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.
Gupta R, Yang Q, Dogra SK, Wajapeyee N., Free PMC Article | 09/30/2017 |
| Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior | Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior.
Amornwatcharapong W, Maenpuen S, Chitnumsub P, Leartsakulpanich U, Chaiyen P. | 09/9/2017 |
| Site-directed mutagenesis experiments on SHMT1 demonstrate that selective enzyme inhibition relies on the presence of a cysteine residue at the active site of SHMT1 (Cys204) that is absent in SHMT2. | Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Paiardini A, Tramonti A, Schirch D, Guiducci G, di Salvo ML, Fiascarelli A, Giorgi A, Maras B, Cutruzzolà F, Contestabile R. | 06/3/2017 |
| SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin. | SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients.
Wang YW, Zhang SD, Xue WJ, Zhu ML, Zheng LZ., Free PMC Article | 04/15/2017 |
| Rs9901160, rs2273027 as well as rs1979277 polymorphism significantly increased the risk of childhood acute lymphoblastic leukemia. | Association of SHMT1 gene polymorphisms with the risk of childhood acute lymphoblastic leukemia in a sample of Iranian population.
Bahari G, Hashemi M, Naderi M, Sadeghi-Bojd S, Taheri M. | 12/17/2016 |
| an association between MTRR 66 and SHMT1 1420 polymorphisms and spaceflight-induced vision changes | Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.
Zwart SR, Gregory JF, Zeisel SH, Gibson CR, Mader TH, Kinchen JM, Ueland PM, Ploutz-Snyder R, Heer MA, Smith SM., Free PMC Article | 06/11/2016 |
| our meta-analysis suggested that the SHMT1 C1420T polymorphism was associated with decreased risk of breast cancer. | Clinical significance of SHMT1 rs1979277 polymorphism in Asian solid tumors: evidence from a meta-analysis.
Zhao TT, Shen LL, Zhang XL, Gu DY, Zhang Q, Huo XY, Tang CJ, Chen JF. | 04/16/2016 |
| SHMT1 knockdown in lung cancer cells leads to cell cycle arrest and to p53-dependent apoptosis. | SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F., Free PMC Article | 07/4/2015 |