| Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis. | Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.
Ghatpande N, Harrer A, Azoulay-Botzer B, Guttmann-Raviv N, Bhushan S, Meinhardt A, Meyron-Holtz EG., Free PMC Article | 08/7/2024 |
| Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages. | Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.
Cheng C, Xing Z, Zhang W, Zheng L, Zhao H, Zhang X, Ding Y, Qiao T, Li Y, Meyron-Holtz EG, Missirlis F, Fan Z, Li K., | 07/29/2024 |
| Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms. | Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.
Nadimpalli HP, Katsioudi G, Arpa ES, Chikhaoui L, Arpat AB, Liechti A, Palais G, Tessmer C, Hofmann I, Galy B, Gatfield D., Free PMC Article | 05/22/2024 |
| Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2. | Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2.
Jia F, Li H, Jiao Q, Li C, Fu L, Cui C, Jiang H, Zhang L., Free PMC Article | 07/30/2022 |
| Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway. | Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Li Y, Jin C, Shen M, Wang Z, Tan S, Chen A, Wang S, Shao J, Zhang F, Zhang Z, Zheng S. | 07/3/2021 |
| Mdm2 is a target and mediator of IRP2 in cell growth control. | Mdm2 is a target and mediator of IRP2 in cell growth control.
Zhang J, Kong X, Zhang Y, Sun W, Xu E, Chen X., Free PMC Article | 10/3/2020 |
| A critical role for Irp2 in the regulation of beta-cell iron homeostasis. | Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.
Santos MCFD, Anderson CP, Neschen S, Zumbrennen-Bullough KB, Romney SJ, Kahle-Stephan M, Rathkolb B, Gailus-Durner V, Fuchs H, Wolf E, Rozman J, de Angelis MH, Cai WM, Rajan M, Hu J, Dedon PC, Leibold EA., Free PMC Article | 04/18/2020 |
| Irp2 deficiency is related to hyperglycemia, which might be due to insulin resistance rather than due to impaired insulin secretion | Iron regulatory protein 2 deficiency may correlate with insulin resistance.
Zhou Y, Wu W, Xu Z, Liu Y, Chang H, Yu P, Zhang X, Yang Y, Liu K, Chang Y. | 11/16/2019 |
| Increased intracellular growth due to compromised expressions of Fpn and FBXL5 by specific siRNAs reveals that Leishmania donovani uses a novel strategy of manipulating IRP2-FBXL5 axis to inhibit host Fpn expression. | Leishmania donovani inhibits ferroportin translation by modulating FBXL5-IRP2 axis for its growth within host macrophages.
Das NK, Sandhya S, G VV, Kumar R, Singh AK, Bal SK, Kumari S, Mukhopadhyay CK. | 05/4/2019 |
| The Irp2(-/-) mice develop microcytic anemia, erythropoietic protoporphyria and a progressive neurological disorder, indicating that Irp2 has important functions in the nervous system and erythropoietic homeostasis | Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.
Ghosh MC, Zhang DL, Rouault TA., Free PMC Article | 08/27/2016 |
| Irp2 mRNA transcription is promoted by circadian clock genes, including BMAL1, and the CLOCK heterodimer. | Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.
Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S., Free PMC Article | 08/6/2016 |
| Irp2 increased mitochondrial iron loading and levels of cytochrome c oxidase, which led to mitochondrial dysfunction and subsequent experimental COPD. | Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM., Free PMC Article | 07/2/2016 |
| IRP1 and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen. | Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection.
Nairz M, Ferring-Appel D, Casarrubea D, Sonnweber T, Viatte L, Schroll A, Haschka D, Fang FC, Hentze MW, Weiss G, Galy B., Free PMC Article | 05/7/2016 |
| aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons. mice show impairments in locomotion, exploration, motor coordination/balance and nociception . | Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA., Free PMC Article | 03/7/2015 |
| misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy | Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.
Jeong SY, Crooks DR, Wilson-Ollivierre H, Ghosh MC, Sougrat R, Lee J, Cooperman S, Mitchell JB, Beaumont C, Rouault TA., Free PMC Article | 02/4/2012 |
| A wide network of mRNAs and proteins with iron-dependent regulation, IRP-dependent regulation, or both. | Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins.
Sanchez M, Galy B, Schwanhaeusser B, Blake J, Bähr-Ivacevic T, Benes V, Selbach M, Muckenthaler MU, Hentze MW. | 01/28/2012 |
| The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. | The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama KI. | 01/21/2012 |
| Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. | Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.
Styś A, Galy B, Starzyński RR, Smuda E, Drapier JC, Lipiński P, Bouton C., Free PMC Article | 09/10/2011 |
| Mice lacking both IRP2 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death. | Iron regulatory proteins secure mitochondrial iron sufficiency and function.
Galy B, Ferring-Appel D, Sauer SW, Kaden S, Lyoumi S, Puy H, Kölker S, Gröne HJ, Hentze MW. | 11/27/2010 |
| IRP2 binding activity reduces ferritin expression in the striatum after an intracerebral hemorrhage, preventing an optimal response to elevated local iron concentrations | Iron regulatory protein-2 knockout increases perihematomal ferritin expression and cell viability after intracerebral hemorrhage.
Chen M, Awe OO, Chen-Roetling J, Regan RF., Free PMC Article | 08/30/2010 |
| A mechanism is proposed by which iron may regulate copper levels in the brain, mediated by IRP2 and amyloid beta protein precursor. | Iron regulatory protein 2 is involved in brain copper homeostasis.
Mueller C, Magaki S, Schrag M, Ghosh MC, Kirsch WM., Free PMC Article | 06/14/2010 |
| the response of Irp1 (-/-) and Irp2 (-/-) mice to acute local inflammation is largely preserved | In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.
Viatte L, Gröne HJ, Hentze MW, Galy B. | 01/21/2010 |
| Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. | Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.
Kerenyi MA, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, Beug H, Moriggl R, Müllner EW., Free PMC Article | 01/21/2010 |
| These results suggest that IRP2 binding activity increases the vulnerability of neurons to hemoglobin, possibly by reducing ferritin expression. Therapeutic strategies that target this regulatory mechanism may be beneficial after hemorrhagic CNS injuries | Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin.
Regan RF, Chen M, Li Z, Zhang X, Benvenisti-Zarom L, Chen-Roetling J., Free PMC Article | 01/21/2010 |
| Tempol protected IRP2(-/-) mice by disassembling the cytosolic iron-sulfur cluster of IRP1 and activating IRE binding activity | Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice.
Ghosh MC, Tong WH, Zhang D, Ollivierre-Wilson H, Singh A, Krishna MC, Mitchell JB, Rouault TA., Free PMC Article | 01/21/2010 |