| BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/beta-catenin pathway. | BLVRA exerts its biological effects to induce malignant properties of hepatocellular carcinoma cells via Wnt/β-catenin pathway.
Chen X, Yang F, Zhang C, Wang X, Yuan C, Shi D, Zhu S, Zhang X, Chen X, Zhao W. | 04/10/2024 |
| Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population. | Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population.
Fan J, He HY, Li HH, Wu PL, Tang L, Deng BY, Dong WH, Wang JH., Free PMC Article | 01/30/2024 |
| Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control. | Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control.
Cimini FA, Barchetta I, Zuliani I, Pagnotta S, Bertoccini L, Dule S, Zampieri M, Reale A, Baroni MG, Cavallo MG, Barone E. | 10/9/2021 |
| Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity. | Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity.
Ceccarelli V, Barchetta I, Cimini FA, Bertoccini L, Chiappetta C, Capoccia D, Carletti R, Di Cristofano C, Silecchia G, Fontana M, Leonetti F, Lenzi A, Baroni MG, Barone E, Cavallo MG., Free PMC Article | 03/6/2021 |
| Associations between G6PD, OATP1B1 and BLVRA variants and susceptibility to neonatal hyperbilirubinaemia in a Chinese Han population. | Associations between G6PD, OATP1B1 and BLVRA variants and susceptibility to neonatal hyperbilirubinaemia in a Chinese Han population.
Li Y, Wu T, Chen L, Zhu Y. | 02/6/2021 |
| TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2. | TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2.
Zhang Z, Amorosa LF, Petrova A, Coyle S, Macor M, Nair M, Lee LY, Haimovich B., Free PMC Article | 10/24/2020 |
| Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells | Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
Klóska D, Kopacz A, Piechota-Polańczyk A, Neumayer C, Huk I, Dulak J, Józkowicz A, Grochot-Przęczek A. | 03/28/2020 |
| Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity. | Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Cimini FA, Arena A, Barchetta I, Tramutola A, Ceccarelli V, Lanzillotta C, Fontana M, Bertoccini L, Leonetti F, Capoccia D, Silecchia G, Di Cristofano C, Chiappetta C, Di Domenico F, Baroni MG, Perluigi M, Cavallo MG, Barone E. | 02/8/2020 |
| Data found that BVR-A interacts with BACE1, and its loss would favor the CKI-mediated phosphorylation of BACE1 and the associated increased Abeta production along with the alteration of brain insulin signaling. These results suggest that the impairment of BVR-A is an early molecular event contributing to both the onset of brain insulin resistance and the increased Abeta production observed in Alzheimer disease. | Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.
Triani F, Tramutola A, Di Domenico F, Sharma N, Butterfield DA, Head E, Perluigi M, Barone E. | 05/25/2019 |
| Genetic polymorphisms of the UGT1A1 promoter, specifically the T-3279G phenobarbital-responsive enhancer module and (TA)7 dinucleotide repeat, as well as the intron and coding region variants of the OATP2, HMOX1, and BLVRA genes, were significantly higher among the cases than the controls. | Genetic Variations in Bilirubin Metabolism Genes and Their Association with Unconjugated Hyperbilirubinemia in Adults.
Chiddarwar AS, D'Silva SZ, Colah RB, Ghosh K, Mukherjee MB. | 06/3/2017 |
| BLVRA mRNA levels in the liver as well as in peripheral blood leukocytes are significantly higher in hepatocellular carcinoma patients most likely as a feedback mechanism to control increased oxidative stress associated with HCC progression. | Predictive role BLVRA mRNA expression in hepatocellular cancer.
Kubícková KN, Subhanová I, Konícková R, Matousová L, Urbánek P, Parobková H, Kupec M, Pudil J, Vítek L. | 03/4/2017 |
| Data suggest that isoenzymes BVRA and BVRB play different roles in energy metabolism and in pathogenesis of abdominal obesity and hypertriglyceridemia. [REVIEW] | Biliverdin reductase isozymes in metabolism.
O'Brien L, Hosick PA, John K, Stec DE, Hinds TD Jr., Free PMC Article | 12/19/2015 |
| Interactions of HO-2 with CPR and BVR, were evaluated. | Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase.
Spencer AL, Bagai I, Becker DF, Zuiderweg ER, Ragsdale SW., Free PMC Article | 02/14/2015 |
| Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway. | Activation of human biliverdin-IXα reductase by urea: generation of kinetically distinct forms during the unfolding pathway.
Franklin E, Mantle T, Dunne A. | 02/22/2014 |
| These findings suggest that hBVR significantly contributes to the modulation of hypoxia-induced chemoresistance of glioblastoma cells by adjusting their cellular redox status. | Biliverdin reductase plays a crucial role in hypoxia-induced chemoresistance in human glioblastoma.
Kim SS, Seong S, Lim SH, Kim SY. | 02/15/2014 |
| Increased biliverdin reductase expression is associated with multidrug resistance in leukemia. | Targeting biliverdin reductase overcomes multidrug resistance in leukemia HL60 cells.
Kim SS, Seong S, Lim SH, Kim SY. | 01/11/2014 |
| Our results suggest that patients with chronic HCV infection significantly upregulate BLVRA expression in PBL. | Expression of Biliverdin Reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients.
Subhanova I, Muchova L, Lenicek M, Vreman HJ, Luksan O, Kubickova K, Kreidlova M, Zima T, Vitek L, Urbanek P., Free PMC Article | 12/28/2013 |
| The current study reports increased levels of both HO-1 and BVR-A in plasma from probable Alzheimer disease patients, as a result of the increased oxidative environment. | HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease.
Di Domenico F, Barone E, Mancuso C, Perluigi M, Cocciolo A, Mecocci P, Butterfield DA, Coccia R. | 04/27/2013 |
| rs699512 (Thr3Ala), the only common non-synonymous SNP within BLVRA, reduced the risk of essential hypertension in Kazaks. | Association of a BLVRA common polymorphism with essential hypertension and blood pressure in Kazaks.
Lin R, Wang X, Zhou W, Fu W, Wang Y, Huang W, Jin L. | 12/3/2011 |
| A significant increase of nitrated BVRA was demonstrated only in Alzheimer's disease and mild cognitive impairment hippocampi | Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
Barone E, Di Domenico F, Cenini G, Sultana R, Coccia R, Preziosi P, Perluigi M, Mancuso C, Butterfield DA. | 12/3/2011 |
| A homozygous BLVRA inactivating mutation is associated with the appearance of green jaundice accompanying cholestasis episodes. | A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis.
Nytofte NS, Serrano MA, Monte MJ, Gonzalez-Sanchez E, Tumer Z, Ladefoged K, Briz O, Marin JJ. | 07/30/2011 |
| data support the notion that BLVRA contributes significantly to modulation of the aging process by adjusting the cellular oxidative status. | Biliverdin reductase A in the prevention of cellular senescence against oxidative stress.
Kim SY, Kang HT, Choi HR, Park SC., Free PMC Article | 05/21/2011 |
| An up-regulation of the biliverdin reductase-A protein levels was found in the hippocampus of the subjects with Alzheimer disease and arguably its earliest form, mild cognitive impairment. | Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment.
Barone E, Di Domenico F, Cenini G, Sultana R, Cini C, Preziosi P, Perluigi M, Mancuso C, Butterfield DA., Free PMC Article | 04/23/2011 |
| hBVR was detected in the nucleus at 1, 2, and 4 h after hypoxia (1% O(2)), at which times its kinase and reductase activities were increased. | Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB.
Gibbs PE, Miralem T, Maines MD., Free PMC Article | 09/27/2010 |
| These observations support direct and indirect antioxidant properties of BVR and bilirubin and an important role for BVR and bilirubin in HO-1 conferred protection of endothelial cells. | Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin.
Jansen T, Hortmann M, Oelze M, Opitz B, Steven S, Schell R, Knorr M, Karbach S, Schuhmacher S, Wenzel P, Münzel T, Daiber A. | 09/13/2010 |