| Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and IL-18 in COPD patients of the Chinese Han population. | Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and IL-18 in COPD patients of the Chinese Han population.
Zhang J, Zhao D, Zhang L, Feng X, Li B, Dong H, Qi Y, Jia Z, Liu F, Zhao S, Zhang J., Free PMC Article | 11/1/2024 |
| Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells. | Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells.
Guo F, Zhang L, Yu Y, Gong L, Tao S, Werder RB, Mishra S, Zhou Y, Anamika WJ, Lao T, Inuzuka H, Zhang Y, Pham B, Liu T, Tufenkjian TS, Richmond BW, Wei W, Mou H, Wilson AA, Hu M, Chen W, Zhou X., Free PMC Article | 03/18/2024 |
| Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein. | Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from cancer-associated fibroblasts promote progression of hepatocellular carcinoma by targeting hedgehog interacting protein.
Jin AL, Ding L, Yang WJ, Liu T, Chen W, Li T, Zhang CY, Pan BS, Qiu SJ, Zhou J, Fan J, Guo W, Yang XR, Wang BL., Free PMC Article | 12/31/2022 |
| Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2. | Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2.
Yang Y, Cheng Y, Mou Y, Tang X, Mu X. | 11/19/2022 |
| Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis. | Association of human Hedgehog interacting protein gene polymorphisms with the risk of chronic obstructive pulmonary disease: a meta-analysis.
Liao Y, Liao Y, Wen F. | 04/30/2022 |
| Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression. | Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression.
Chakraborty B, Basu M, Mukhopadhyay D, Alam N, Ghosh S, Dutta S, Panda CK. | 04/16/2022 |
| Long noncoding RNA HHIPAS1 inhibits lung cancer epithelialmesenchymal transition and stemness by regulating PCDHGA9. | Long non‑coding RNA HHIP‑AS1 inhibits lung cancer epithelial‑mesenchymal transition and stemness by regulating PCDHGA9.
Zhou Z, Lai Y, Cao S, Zhuo Q, Tang H., Free PMC Article | 02/5/2022 |
| Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C., Free PMC Article | 01/22/2022 |
| Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. | Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells.
Li Y, Zhang L, Polverino F, Guo F, Hao Y, Lao T, Xu S, Li L, Pham B, Owen CA, Zhou X., Free PMC Article | 10/30/2021 |
| Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells. | Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.
Li P, Zhang X, Murphy AJ, Costa M, Zhao X, Sun H., Free PMC Article | 06/26/2021 |
| Transfer of miR-25-3p by CHB-PNALT-Exo promoted the development of liver cancer by inhibiting the co-expression of TCF21 and HHIP. | Exosomes secreted by chronic hepatitis B patients with PNALT and liver inflammation grade ≥ A2 promoted the progression of liver cancer by transferring miR-25-3p to inhibit the co-expression of TCF21 and HHIP.
Ouyang Y, Tang Y, Fu L, Peng S, Wu W, Tan D, Fu X., Free PMC Article | 08/12/2020 |
| HHIP-AS1 interacted with and positively regulated the stability of HHIP mRNA in a HuR-dependent manner in the hepatocellular carcinoma. | A novel long noncoding RNA HHIP-AS1 suppresses hepatocellular carcinoma progression through stabilizing HHIP mRNA.
Bo C, Li X, He L, Zhang S, Li N, An Y. | 07/25/2020 |
| presence of the A allele in the rs13118928 polymorphism of the HHIP gene may be related to the emphysema-hyperinflation phenotype | Evaluation Of HHIP Polymorphisms And Their Relationship With Chronic Obstructive Pulmonary Disease Phenotypes.
Bártholo TP, Porto LC, Pozzan R, Nascimento A, Da Costa CH., Free PMC Article | 04/18/2020 |
| HHIP regulates apoptosis evasion and angiogenic function of late endothelial progenitor cells. | Hedgehog-Interacting Protein (HIP) Regulates Apoptosis Evasion and Angiogenic Function of Late Endothelial Progenitor Cells.
Lee BNR, Son YS, Lee D, Choi YJ, Kwon SM, Chang HK, Kim PH, Cho JY., Free PMC Article | 06/29/2019 |
| HHIP SNPs were associated with the occurrence of lung cancer in COPD patients in the Chinese Han population. | Correlation between lung cancer and the HHIP polymorphisms of chronic obstructive pulmonary disease (COPD) in the Chinese Han population.
Xu J, Shang Y, Cai F, Zhang S, Xiao Z, Wang H, Fan Y, Li T, Sheng S, Fu Y, Chi F, Zhou C. | 05/25/2019 |
| HHIP G516R, a missense mutation increased cell proliferation and promoted cell migration in thyroid cancer. | Whole Exome Sequencing Identifies a Novel Hedgehog-Interacting Protein G516R Mutation in Locally Advanced Papillary Thyroid Cancer.
Lee WK, Lee SG, Yim SH, Kim D, Kim H, Jeong S, Jung SG, Jo YS, Lee J., Free PMC Article | 01/19/2019 |
| The rate of methylation of ZIC1, ZIC4, HHIP, and DACT2 in tumors was very high, while methylation of CXXC4 was low to moderate in OSCC and LSCC. | Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.
Paluszczak J, Wiśniewska D, Kostrzewska-Poczekaj M, Kiwerska K, Grénman R, Mielcarek-Kuchta D, Jarmuż-Szymczak M., Free PMC Article | 06/2/2018 |
| Genetic variants in HHIP were related with FEV1/FVC in Chronic Obstructive Pulmonary Disease (COPD). Significant relationships between risk alleles and risk genotypes and FEV1/FVC in COPD were also identified. | Genetic Variants in the Hedgehog Interacting Protein Gene Are Associated with the FEV1/FVC Ratio in Southern Han Chinese Subjects with Chronic Obstructive Pulmonary Disease.
Zhang Z, Wang J, Zheng Z, Chen X, Zeng X, Zhang Y, Li D, Shu J, Yang K, Lai N, Dong L, Lu W., Free PMC Article | 03/17/2018 |
| HHIP underexpression is associated with lung adenocarcinoma. | Hedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinoma.
Lin EH, Kao YR, Lin CA, Kuo TY, Yang SP, Hsu CF, Chou TY, Ho CC, Wu CW., Free PMC Article | 01/20/2018 |
| HHIP plays a role in lung branching development, and reduced levels of HHIP ultimately result in lung hypoplasia. | The Well-Known Gene HHIP and Novel Gene MECR Are Implicated in Small Airway Obstruction.
van der Plaat DA, de Jong K, Lahousse L, Faiz A, Vonk JM, van Diemen CC, Nedeljkovic I, Amin N, Obeidat M, van Duijn CM, Boezen HM, Postma DS. | 12/30/2017 |
| Single nucleotide polymorphism in HHIP gene is associated with chronic obstructive pulmonary disease. | Comparison of the role of HHIP SNPs in susceptibility to chronic obstructive pulmonary disease between Chinese Han and Mongolian populations.
Xu G, Gao X, Zhang S, Wang Y, Ding M, Liu W, Shen J, Sun D. | 12/16/2017 |
| loss of AT2 R is associated with podocyte loss/dysfunction and is mediated, at least in part, via augmented ectopic hedgehog interacting protein expression in podocytes | AT(2) R deficiency mediated podocyte loss via activation of ectopic hedgehog interacting protein (Hhip) gene expression.
Liao MC, Zhao XP, Chang SY, Lo CS, Chenier I, Takano T, Ingelfinger JR, Zhang SL. | 11/11/2017 |
| this study shows that HHIP confers a risk for airway obstruction in general that is not driven exclusively by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease | Genome-wide association study on the FEV(1)/FVC ratio in never-smokers identifies HHIP and FAM13A.
van der Plaat DA, de Jong K, Lahousse L, Faiz A, Vonk JM, van Diemen CC, Nedeljkovic I, Amin N, Brusselle GG, Hofman A, Brandsma CA, Bossé Y, Sin DD, Nickle DC, van Duijn CM, Postma DS, Boezen HM. | 08/5/2017 |
| Results showed that smoking and HHIP variant rs7654947 were associated with chronic obstructive pulmonary disease (COPD)development and lung function decline. Moreover, we found that cigarette smoking and gene susceptibility have cooperative effects on COPD risk and lung function decline | Smoking status and gene susceptibility play important roles in the development of chronic obstructive pulmonary disease and lung function decline: A population-based prospective study.
Zhao J, Li M, Chen J, Wu X, Ning Q, Zhao J, Xu Y, Xie J, Yu J., Free PMC Article | 07/22/2017 |
| This work supports a feasible vicious cycle in which EMPs generated during endothelial injury, in turn, aggravate endothelial damage by carrying HHIP into target ECs, contributing to the continuously deteriorating endothelial damage in the development of aGVHD. EMPs harboring HHIP would represent a potential therapeutic target for aGVHD. | Endothelial microparticles carrying hedgehog-interacting protein induce continuous endothelial damage in the pathogenesis of acute graft-versus-host disease.
Nie DM, Wu QL, Zheng P, Chen P, Zhang R, Li BB, Fang J, Xia LH, Hong M. | 05/27/2017 |