| Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice. | Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice.
Chen JX, Zhang J, Chen Y, Zeng H., Free PMC Article | 10/21/2024 |
| Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice. | Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice.
Richardson KK, Adam GO, Ling W, Warren A, Marques-Carvalho A, Thostenson JD, Krager K, Aykin-Burns N, Byrum SD, Almeida M, Kim HN., Free PMC Article | 09/23/2024 |
| Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis. | Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis.
Li Y, Kong E, Ding R, Chu R, Lu J, Deng M, Hua T, Yang M, Wang H, Chen D, Song H, Wei H, Zhang P, Han C, Yuan H., Free PMC Article | 09/18/2024 |
| Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis. | Intrauterine hyperglycemia induces SIRT3-mediated mitochondrial dysfunction: the fetal origin pathogenesis of precocious osteoarthritis.
Li X, Zhu W, Cheng Y, Ren Z, Liu X, Yang H, Ding G, Huang H. | 08/16/2024 |
| Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury. | Sex-related differences in SIRT3-mediated mitochondrial dynamics in renal ischemia/reperfusion injury.
Yao H, Zhao H, Du Y, Zhang Y, Li Y, Zhu H. | 06/21/2024 |
| FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control. | FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control.
Ge Y, Wu X, Cai Y, Hu Q, Wang J, Zhang S, Zhao B, Cui W, Wu Y, Wang Q, Feng T, Liu H, Qu Y, Ge S., Free PMC Article | 06/5/2024 |
| Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity. | Dual modifying of MAVS at lysine 7 by SIRT3-catalyzed deacetylation and SIRT5-catalyzed desuccinylation orchestrates antiviral innate immunity.
Liu X, Zhu C, Jia S, Deng H, Tang J, Sun X, Zeng X, Chen X, Wang Z, Liu W, Liao Q, Zha H, Cai X, Xiao W., Free PMC Article | 04/26/2024 |
| Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus. | Sirtuin 3 regulates astrocyte activation by reducing Notch1 signaling after status epilepticus.
Zhu J, Park S, Kim SH, Kim CH, Jeong KH, Kim WJ. | 04/24/2024 |
| SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARgamma-mediated mechanism. | SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.
Liu LX, Zheng XH, Hai JH, Zhang CM, Ti Y, Chen TS, Bu PL., Free PMC Article | 04/24/2024 |
| Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling. | Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3-SOD2-mtROS signaling.
Xie S, Zou W, Liu S, Yang Q, Hu T, Zhu WP, Tang H, Wang C. | 04/15/2024 |
| Downregulation of Sirt3 contributes to beta-cell dedifferentiation via FoxO1 in type 2 diabetic mellitus. | Downregulation of Sirt3 contributes to β-cell dedifferentiation via FoxO1 in type 2 diabetic mellitus.
Nie Y, Zhang Y, Liu S, Xu Z, Xia C, Du L, Yin X, Wang J. | 03/29/2024 |
| Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis. | Role of Argininosuccinate Synthase 1 -Dependent L-Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis.
Cao X, Wu VWY, Han Y, Hong H, Wu Y, Kong APS, Lui KO, Tian XY., Free PMC Article | 03/28/2024 |
| Sirtuin 3 (SIRT3) improves sevoflurane-induced postoperative cognitive impairment by regulating mitochondrial oxidative stress. | Sirtuin 3 (SIRT3) improves sevoflurane-induced postoperative cognitive impairment by regulating mitochondrial oxidative stress.
Dai C, Fu C, Yi Z, Guan X, Deng J. | 03/14/2024 |
| Sirt3 Regulates Proliferation and Progesterone Production in Leydig Cells via Suppression of Reactive Oxygen Species. | Sirt3 Regulates Proliferation and Progesterone Production in Leydig Cells via Suppression of Reactive Oxygen Species.
Matoba H, Fujii C, Maruyama K, Kawakubo M, Momose M, Sano K, Imamura H, Kurihara H, Nakayama J. | 02/27/2024 |
| Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis. | Sirtuin 3 is required for the dexmedetomidine-mediated alleviation of inflammation and oxidative stress in nephritis.
Lu K, Li X, Wu J., Free PMC Article | 02/27/2024 |
| Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy. | Sirtuin3 promotes the degradation of hepatic Z alpha-1 antitrypsin through lipophagy.
Poole B, Oshins R, Huo Z, Aranyos A, West J, Duarte S, Clark VC, Beduschi T, Zarrinpar A, Brantly M, Khodayari N., Free PMC Article | 02/21/2024 |
| The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy. | The SIRT3-ATAD3A axis regulates MAM dynamics and mitochondrial calcium homeostasis in cardiac hypertrophy.
Li Z, Hu O, Xu S, Lin C, Yu W, Ma D, Lu J, Liu P., Free PMC Article | 02/16/2024 |
| Electroacupuncture Mediates Fat Metabolism and Autophagy via a Sirt3-Dependent Mechanism in Mice Fed High-Fat Diet. | Electroacupuncture Mediates Fat Metabolism and Autophagy via a Sirt3-Dependent Mechanism in Mice Fed High-Fat Diet.
Wang M, Sun Z, Ou Y, Ge W, Yuan M, Xu B. | 02/15/2024 |
| Sirt3 Deletion Increases Inflammation and Mortality in Polymicrobial Sepsis. | Sirt3 Deletion Increases Inflammation and Mortality in Polymicrobial Sepsis.
Labiner HE, Sas KM, Baur JA, Sims CA., Free PMC Article | 12/1/2023 |
| 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function. | 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.
Moellmann J, Krueger K, Wong DWL, Klinkhammer BM, Buhl EM, Dehairs J, Swinnen JV, Noels H, Jankowski J, Lebherz C, Boor P, Marx N, Lehrke M. | 11/16/2023 |
| Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2. | Intermittent fasting promotes adipocyte mitochondrial fusion through Sirt3-mediated deacetylation of Mdh2.
Li Y, Liang J, Tian X, Chen Q, Zhu L, Wang H, Liu Z, Dai X, Bian C, Sun C. | 11/1/2023 |
| Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice. | Restoration of SIRT3 gene expression by airway delivery resolves age-associated persistent lung fibrosis in mice.
Rehan M, Kurundkar D, Kurundkar AR, Logsdon NJ, Smith SR, Chanda D, Bernard K, Sanders YY, Deshane JS, Dsouza KG, Rangarajan S, Zmijewski JW, Thannickal VJ., Free PMC Article | 10/20/2023 |
| SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice. | SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, Wang H, Ji Y, Xie LP, Gu AH, Sun CQ, Wang QM, Wang LS. | 10/13/2023 |
| Sirt3 deficiency promotes endothelial dysfunction and aggravates renal injury. | Sirt3 deficiency promotes endothelial dysfunction and aggravates renal injury.
Pezzotta A, Perico L, Corna D, Morigi M, Remuzzi G, Benigni A, Imberti B., Free PMC Article | 10/12/2023 |
| SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1. | SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1.
Li R, Wang Z, Wang Y, Sun R, Zou B, Tian X, Liu D, Zhao X, Zhou J, Zhao Y, Yao J. | 09/25/2023 |