| Autoregulated splicing of TRA2beta programs T cell fate in response to antigen-receptor stimulation. | Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation.
Karginov TA, Ménoret A, Leclair NK, Harrison AG, Chandiran K, Suarez-Ramirez JE, Yurieva M, Karlinsey K, Wang P, O'Neill RJ, Murphy PA, Adler AJ, Cauley LS, Anczuków O, Zhou B, Vella AT. | 09/13/2024 |
| Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation. | Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.
Chen G, Chen J, Qi L, Yin Y, Lin Z, Wen H, Zhang S, Xiao C, Bello SF, Zhang X, Nie Q, Luo W., Free PMC Article | 02/9/2024 |
| Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome. | Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome.
Ramond F, Dalgliesh C, Grimmel M, Wechsberg O, Vetro A, Guerrini R, FitzPatrick D, Poole RL, Lebrun M, Bayat A, Grasshoff U, Bertrand M, Witt D, Turnpenny PD, Faundes V, Santa María L, Mendoza Fuentes C, Mabe P, Hussain SA, Mullegama SV, Torti E, Oehl-Jaschkowitz B, Salmon LB, Orenstein N, Shahar NR, Hagari O, Bazak L, Hoffjan S, Prada CE, Haack T, Elliott DJ. | 04/12/2023 |
| Tra2beta Enhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer. | Tra2β Enhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer.
Li MJ, Xiong D, Wang S, Huang H. | 03/6/2023 |
| MicroRNA-330-3p represses the proliferation and invasion of laryngeal squamous cell carcinoma through downregulation of Tra2beta-mediated Akt signaling. | MicroRNA-330-3p represses the proliferation and invasion of laryngeal squamous cell carcinoma through downregulation of Tra2β-mediated Akt signaling.
Cheng Y, Zhu H, Gao W. | 06/5/2021 |
| Tra2beta protects against the degeneration of chondrocytes by inhibiting chondrocyte apoptosis via activating the PI3K/Akt signaling pathway. | Tra2β protects against the degeneration of chondrocytes by inhibiting chondrocyte apoptosis via activating the PI3K/Akt signaling pathway.
Zhou C, Wang KS, Peng W, Yuan FL, Si ZP. | 05/15/2021 |
| Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B. | Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B.
Zhang H, Wang J, Ren T, Huang Y, Liang X, Yu Y, Wang W, Niu J, Guo W. | 01/23/2021 |
| HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells. | HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.
Nishikawa T, Kuwano Y, Takahara Y, Nishida K, Rokutan K., Free PMC Article | 10/24/2020 |
| Findings demonstrate that Tra2b is upregulated in non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Furthermore, Tra2b was identified as a direct target of miR-335. These results indicate that the interaction between miR-335 and Tra2b may play a vital role in the pathogenesis of NSCLC. | miR-335 inhibited cell proliferation of lung cancer cells by target Tra2β.
Liu J, Bian T, Feng J, Qian L, Zhang J, Jiang D, Zhang Q, Li X, Liu Y, Shi J., Free PMC Article | 02/10/2018 |
| It seems that a new signaling axis, SIRT1-SFRS10-LPIN1 axis, acting in the pathogenesis of alcoholic fatty liver disease exists. | Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease.
Li Y, Zhou J., Free PMC Article | 07/15/2017 |
| that TRA2beta promotes glioma cell growth and migration, and could be a candidate for molecular targeting during gene therapy treatments of glioma | Knocking down the expression of TRA2β inhibits the proliferation and migration of human glioma cells.
Yang L, Tao T, Wang Y, Bao Z, He X, Cui G. | 09/10/2016 |
| Tra2beta was significantly upregulated in prostate carcinoma, and multivariate analysis confirmed Tra2beta as an independent prognostic factor. | Prognostic value of transformer 2β expression in prostate cancer.
Diao Y, Wu D, Dai Z, Kang H, Wang Z, Wang X., Free PMC Article | 06/4/2016 |
| Overexpression of either Tra2alpha or Tra2beta results in a marked reduction in HIV-1 Gag/ Env expression. | Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression.
Platt C, Calimano M, Nemet J, Bubenik J, Cochrane A., Free PMC Article | 02/6/2016 |
| Results showed that HNRNPG and HTRA2-BETA1 were specific antagonistic regulators of ERa exon7 splicing and increased HNRNPG levels were associated with improved clinical outcome of endometrial cancer through up-regulation of ERaD7 expression. | HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer.
Hirschfeld M, Ouyang YQ, Jaeger M, Erbes T, Orlowska-Volk M, Zur Hausen A, Stickeler E., Free PMC Article | 01/16/2016 |
| findings suggest that Tra2beta regulates apoptosis by modulating Bcl-2 expression through its competition with miR-204. This novel function may have a crucial role in tumor growth. | Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA.
Kuwano Y, Nishida K, Kajita K, Satake Y, Akaike Y, Fujita K, Kano S, Masuda K, Rokutan K., Free PMC Article | 12/26/2015 |
| SRPK1 is a regulator of Tra2beta1 splicing function and individual domains engage in considerable cross-talk, assuming novel functions with regard to RNA binding, splicing, and catalysis. | Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1.
Jamros MA, Aubol BE, Keshwani MM, Zhang Z, Stamm S, Adams JA., Free PMC Article | 10/3/2015 |
| Simultaneous depletion of Tra2alpha and Tra2beta induces substantial shifts in splicing of endogenous Tra2beta target exons, and both constitutive and alternative target exons are under dual Tra2alpha-Tra2beta control. | Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons.
Best A, James K, Dalgliesh C, Hong E, Kheirolahi-Kouhestani M, Curk T, Xu Y, Danilenko M, Hussain R, Keavney B, Wipat A, Klinck R, Cowell IG, Cheong Lee K, Austin CA, Venables JP, Chabot B, Santibanez Koref M, Tyson-Capper A, Elliott DJ., Free PMC Article | 07/25/2015 |
| Results indicate that transformer 2beta (Tra2beta) was involved in the tumorigenesis of NSCLC and might be a potential therapeutic target of non-small cell lung cancer (NSCLC). | Transformer 2β (Tra2β/SFRS10) positively regulates the progression of NSCLC via promoting cell proliferation.
Ji L, Ni T, Shen Y, Xue Q, Liu Y, Chen B, Cui X, Lv L, Yu X, Cui Y, Lu X, Chen J, Mao G, Wang Y. | 05/16/2015 |
| Facilitating Tra2beta-dependent inclusion of exons in target pre-mRNAs. | HuR regulates alternative splicing of the TRA2β gene in human colon cancer cells under oxidative stress.
Akaike Y, Masuda K, Kuwano Y, Nishida K, Kajita K, Kurokawa K, Satake Y, Shoda K, Imoto I, Rokutan K., Free PMC Article | 09/6/2014 |
| Oxidative stress-responsive Transformer 2beta may play an important role in colon cancer growth. | Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells.
Kajita K, Kuwano Y, Kitamura N, Satake Y, Nishida K, Kurokawa K, Akaike Y, Honda M, Masuda K, Rokutan K. | 07/12/2014 |
| SFRS10 is not expressed in normal human retinae but is upregulated in Age-related macular degeneration retinae. | Expression analysis of an evolutionarily conserved alternative splicing factor, Sfrs10, in age-related macular degeneration.
Karunakaran DK, Banday AR, Wu Q, Kanadia R., Free PMC Article | 06/21/2014 |
| Specific induction of hTra2beta1 due to Alternative splicing is associated with epithelial ovarian cancer. | Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact.
Iborra S, Hirschfeld M, Jaeger M, Zur Hausen A, Braicu I, Sehouli J, Gitsch G, Stickeler E. | 02/22/2014 |
| analysis of mechanisms by which the subcellular and subnuclear localization of Tra2beta proteins are regulated | Characterization of nuclear localization signals (NLSs) and function of NLSs and phosphorylation of serine residues in subcellular and subnuclear localization of transformer-2β (Tra2β).
Li SJ, Qi Y, Zhao JJ, Li Y, Liu XY, Chen XH, Xu P., Free PMC Article | 06/1/2013 |
| findings show the inclusion of both HIV-1 exon 3 and vpr mRNA processing is promoted by an exonic splicing enhancer (ESEvpr) localized between exonic splicing silencer ESSV and 5'ss D3; the ESEvpr sequence was found to be bound by members of the Tra2 protein family | Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA.
Erkelenz S, Poschmann G, Theiss S, Stefanski A, Hillebrand F, Otte M, Stühler K, Schaal H., Free PMC Article | 04/27/2013 |
| reduced expression of SFRS10, as observed in tissues from obese humans, alters LPIN1 splicing, induces lipogenesis, and therefore contributes to metabolic phenotypes associated with obesity. | Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.
Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME., Free PMC Article | 01/7/2012 |