| Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses. | Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses.
Choi SY, Ahn YR, Lee EB, Yu MJ, Lee JR., Free PMC Article | 04/23/2022 |
| Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation. | Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation.
Yang C, Li Q, Chen X, Zhang Z, Mou Z, Ye F, Jin S, Jun X, Tang F, Jiang H., Free PMC Article | 02/27/2021 |
| Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network. | Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network.
Di Gregorio SE, Volkening K, Strong MJ, Duennwald ML., Free PMC Article | 02/20/2021 |
| Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis. | Rare, low-frequency and common coding variants of ARHGEF28 gene and their association with sporadic amyotrophic lateral sclerosis.
Song Y, Lin F, Ye CH, Huang H, Li X, Yao X, Xu Y, Wang C. | 10/31/2020 |
| A new role for Rgnef in ovarian cancer to facilitate NF-kappaB-mediated gene expression protecting cells from oxidative stress. | Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.
Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD., Free PMC Article | 02/1/2020 |
| Data show interaction between activated Rac family small GTPase 1 (Rac1) and Rho guanine nucleotide exchange factor 28 (p190RhoGEF), suggeseting a potential mechanism for cross-talk regulation where Rac can directly effect stimulation of small GTP binding protein RhoA (RhoA). | Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.
Dada O, Gutowski S, Brautigam CA, Chen Z, Sternweis PC., Free PMC Article | 10/12/2019 |
| a 23-amino acid region containing a bipartite nuclear localization signal (NLS) within the Pleckstrin Homology (PH) domain of RGNEF, which when deleted or mutated abolishes the nuclear localization of this protein. | A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization.
Tavolieri MV, Droppelmann CA, Campos-Melo D, Volkening K, Strong MJ. | 03/9/2019 |
| results show that Rgnef functions as an effector of Galpha13 signaling and that this linkage may mediate FAK activation in DLD-1 colon carcinoma cells | Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.
Masià-Balagué M, Izquierdo I, Garrido G, Cordomí A, Pérez-Benito L, Miller NL, Schlaepfer DD, Gigoux V, Aragay AM., Free PMC Article | 09/12/2015 |
| This study showed that ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort. | ARHGEF28 gene exon 6/intron 6 junction mutations in Chinese amyotrophic lateral sclerosis cohort.
Ma Y, Tang L, Chen L, Zhang B, Deng P, Wang J, Yang Y, Liu R, Yang Y, Ye S, Liu X, Zhang H, Fan D. | 01/10/2015 |
| Study identified a heterozygous mutation in amyotrophic lateral sclerosis patients that is predicted to generate a premature truncated ARHGEF28 gene product. There were extensive regions of homozygosity in the ARHGEF28 gene in two familial ALS patients. | Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis.
Droppelmann CA, Wang J, Campos-Melo D, Keller B, Volkening K, Hegele RA, Strong MJ. | 10/19/2013 |
| This study demonistrated that RGNEF-immunoreactive neuronal cytoplasmic inclusions (NCIs) can co-localize with TDP-43, FUS/TLS and p62 within spinal motor neurons. | Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism.
Keller BA, Volkening K, Droppelmann CA, Ang LC, Rademakers R, Strong MJ. | 03/30/2013 |
| Studies identify Rgnef as a novel regulator of colon carcinoma motility and invasion, and they show that a Rgnef-FAK linkage promotes colon carcinoma progression in vivo. | p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.
Yu HG, Nam JO, Miller NL, Tanjoni I, Walsh C, Shi L, Kim L, Chen XL, Tomar A, Lim ST, Schlaepfer DD., Free PMC Article | 03/19/2011 |
| RGNEF is a human homologue of p190RhoGEF, and its RNA is expressed in both brain and spinal cord | Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans.
Volkening K, Leystra-Lantz C, Strong MJ. | 08/9/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ., Free PMC Article | 04/7/2010 |