| STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development. | STRA6 is essential for induction of vascular smooth muscle lineages in human embryonic cardiac outflow tract development.
Zhou C, Häneke T, Rohner E, Sohlmér J, Kameneva P, Artemov A, Adameyko I, Sahara M., Free PMC Article | 05/24/2023 |
| Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer. | Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer.
Yang F, Xu P, Yao S, Li M, Bian Z, Huang Z. | 03/14/2023 |
| STRA6 regulates tumor immune microenvironment and is a prognostic marker in BRAF-mutant papillary thyroid carcinoma. | STRA6 regulates tumor immune microenvironment and is a prognostic marker in BRAF-mutant papillary thyroid carcinoma.
He W, Sun Y, Ge J, Wang X, Lin B, Yu S, Li Y, Hong S, Xiao H., Free PMC Article | 03/1/2023 |
| The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome. | The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.
Berner D, Hoja U, Zenkel M, Ross JJ, Uebe S, Paoli D, Frezzotti P, Rautenbach RM, Ziskind A, Williams SE, Carmichael TR, Ramsay M, Topouzis F, Chatzikyriakidou A, Lambropoulos A, Sundaresan P, Ayub H, Akhtar F, Qamar R, Zenteno JC, Cruz-Aguilar M, Astakhov YS, Dubina M, Wiggs J, Ozaki M, Kruse FE, Aung T, Reis A, Khor CC, Pasutto F, Schlötzer-Schrehardt U., Free PMC Article | 09/4/2021 |
| STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer. | STRA6 Expression Serves as a Prognostic Biomarker of Gastric Cancer.
Nakamura S, Kanda M, Shimizu D, Sawaki K, Tanaka C, Hattori N, Hayashi M, Yamada S, Nakayama G, Omae K, Koike M, Kodera Y., Free PMC Article | 05/8/2021 |
| Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade. | Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade.
Chen CH, Ke LY, Chan HC, Chu CS, Lee AS, Lin KD, Lee MY, Hsiao PJ, Chen CH, Shin SJ., Free PMC Article | 02/20/2021 |
| STRA6 is down-regulated by miR-873 and plays an oncogenic role by activating Wnt/beta-catenin signalling in GC. | STRA6 exerts oncogenic role in gastric tumorigenesis by acting as a crucial target of miR-873.
Lin L, Xiao J, Shi L, Chen W, Ge Y, Jiang M, Li Z, Fan H, Yang L, Xu Z., Free PMC Article | 03/28/2020 |
| SRC-2 is required for full induction of the retinol transporter, stimulated by retinoic acid 6 (STRA6), which is essential for endometrial stromal cell decidualization. | Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics.
Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O'Malley BW, Lydon JP., Free PMC Article | 05/4/2019 |
| significant association between STRA6 polymorphism and Gestational diabetes mellitus in Chinese Han population | Association of polymorphisms in STRA6 gene with gestational diabetes mellitus in a Chinese Han population.
Hu S, Yan J, You Y, Yang G, Zhou H, Li X, Liao X, Tan H., Free PMC Article | 04/6/2019 |
| We demonstrate that mutations in STRA6 are the cause for syndromic anophthalmia in the original Matthew-Wood patient | Novel STRA6 null mutations in the original family described with Matthew-Wood syndrome.
Pasutto F, Flinter F, Rauch A, Reis A. | 03/9/2019 |
| Mutations in retinoic acid 6 gene (STRA6) have been reported in clinically diagnosed patients with MWS. Here we presented a case with MWS, who has characteristic findings of the syndrome as well as dextrocardia as an undescribed feature, and bilateral streak gonads which was described only in one patient previously. Molecular analysis showed a homozygous exonic missense mutation in the STRA6 gene. | MATTHEW-WOOD SYNDROME: A CASE WITH DEXTROCARDIA AND STREAK GONADS.
Cubuk PO, Ho L, Reversade B, Perçin EF. | 10/20/2018 |
| The knockdown of STRA6 slightly enhanced nodule formation at the late stage of osteoblast differentiation, and overexpression of STRA6 in ST2 cells enhanced adipocyte differentiation. | STRA6 as a possible candidate gene for pathogenesis of osteoporosis from RNA‑seq analysis of human mesenchymal stem cells.
Song I, Choi YJ, Jin Y, Kim JW, Koh JT, Ji HM, Jeong SY, Won YY, Kim W, Chung YS., Free PMC Article | 06/16/2018 |
| these data demonstrate a key role of STRA6 and RBP4 in the maintenance of colon cancer self-renewal and that this pathway is an important link through which consumption of HFD contributes to colon carcinogenesis. | RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.
Karunanithi S, Levi L, DeVecchio J, Karagkounis G, Reizes O, Lathia JD, Kalady MF, Noy N., Free PMC Article | 04/28/2018 |
| this study suggested that a role of STRA6 polymorphism could also be of value in predicting the risk of type 2 diabetes mellitus(T2DM) while RARRES2 polymorphism could not predict the risk of T2DM | Association of Polymorphisms in STRA6 and RARRES2 Genes with Type 2 Diabetes in Southern Han Chinese.
Huang HW, Liang BY, Li YX., Free PMC Article | 02/18/2017 |
| A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly. | A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly.
Marcadier JL, Mears AJ, Woods EA, Fisher J, Airheart C, Qin W, Beaulieu CL, Dyment DA, Innes AM, Curry CJ, Care4Rare Canada Consortium. | 10/22/2016 |
| These data establish that holo-RBP and its receptor STRA6 are potent oncogenes and suggest that the pathway is a novel target for therapy of some human cancers. | Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation.
Berry DC, Levi L, Noy N., Free PMC Article | 01/10/2015 |
| Evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, in STRA6. | Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein.
Zhong M, Kawaguchi R, Ter-Stepanian M, Kassai M, Sun H., Free PMC Article | 08/23/2014 |
| STRA6 has a role for regulating retinoid homeostasis and in helping to program signaling that drives proliferation and differentiation of human skin cells | Downregulation of STRA6 expression in epidermal keratinocytes leads to hyperproliferation-associated differentiation in both in vitro and in vivo skin models.
Skazik C, Amann PM, Heise R, Marquardt Y, Czaja K, Kim A, Rühl R, Kurschat P, Merk HF, Bickers DR, Baron JM., Free PMC Article | 07/12/2014 |
| Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. | Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.
Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S., Free PMC Article | 10/26/2013 |
| Analysis of FRAS1 and STRA6 mutations in the same family with eye anomalies. | A puzzle over several decades: eye anomalies with FRAS1 and STRA6 mutations in the same family.
Ng WY, Pasutto F, Bardakjian TM, Wilson MJ, Watson G, Schneider A, Mackey DA, Grigg JR, Zenker M, Jamieson RV. | 10/19/2013 |
| Findings suggest that heterozygosity for the STRA6 gene mutation may be associated with ocular abnormalities. | Mutation analysis of the STRA6 gene in isolated and non-isolated anophthalmia/microphthalmia.
Chassaing N, Ragge N, Kariminejad A, Buffet A, Ghaderi-Sohi S, Martinovic J, Calvas P. | 08/31/2013 |
| TTR blocks the ability of holo-retinol-binding protein to associate with STRA6 and thereby effectively suppresses both STRA6-mediated retinol uptake and STRA6-initiated cell signaling. | Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6.
Berry DC, Croniger CM, Ghyselinck NB, Noy N., Free PMC Article | 12/8/2012 |
| STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin. | Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6.
Berry DC, O'Byrne SM, Vreeland AC, Blaner WS, Noy N., Free PMC Article | 10/13/2012 |
| STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS. | First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype.
Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J, Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Chróinín MN, Kennedy BN, Lynch S, Green A, Ennis S., Free PMC Article | 03/31/2012 |
| SNPs in STRA6, gene coding the cell surface receptor for RBP4, were significantly associated with type 2 diabetes and further genetic and functional studies are required to understand and ascertain its role in the manifestation of type 2 diabetes. | Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.
Nair AK, Sugunan D, Kumar H, Anilkumar G., Free PMC Article | 10/30/2010 |