| CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders. | CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders.
van Karnebeek CDM, Tarailo-Graovac M, Leen R, Meinsma R, Correard S, Jansen-Meijer J, Prykhozhij SV, Pena IA, Ban K, Schock S, Saxena V, Pras-Raves ML, Drögemöller BI, Grootemaat AE, van der Wel NN, Dobritzsch D, Roseboom W, Schomakers BV, Jaspers YRJ, Zoetekouw L, Roelofsen J, Ferreira CR, van der Lee R, Ross CJ, Kochan J, McIntyre RL, van Klinken JB, van Weeghel M, Kramer G, Weschke B, Labrune P, Willemsen MA, Riva D, Garavaglia B, Moeschler JB, Filiano JJ, Ekker M, Berman JN, Dyment D, Vaz FM, Wasserman WW, Houtkooper RH, van Kuilenburg ABP. | 10/30/2024 |
| The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells. | The c-MYC transcription factor conduces to resistance to cisplatin by regulating MMS19 in bladder cancer cells.
Ren D, Li L, Wang S, Zuo Y. | 06/25/2023 |
| Structural insights into Fe-S protein biogenesis by the CIA targeting complex. | Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Kassube SA, Thomä NH. | 11/21/2020 |
| findings suggest that MMS19 plays an essential role in maintaining mitochondrial genome stability | MMS19 localizes to mitochondria and protects the mitochondrial genome from oxidative damage.
Wu R, Tan Q, Niu K, Zhu Y, Wei D, Zhao Y, Fang H. | 06/16/2018 |
| POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19. | Human DNA polymerase ε is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 and MMS19.
Moiseeva TN, Gamper AM, Hood BL, Conrads TP, Bakkenist CJ., Free PMC Article | 05/20/2017 |
| We therefore propose the expression level of MMS19 as a candidate predictive marker of ACT benefit in resected NSCLC patients. | MMS19 as a potential predictive marker of adjuvant chemotherapy benefit in resected non-small cell lung cancer.
Adam J, Sourisseau T, Olaussen KA, Robin A, Zhu CQ, Templier A, Civet A, Girard P, Lazar V, Validire P, Tsao MS, Soria JC, Besse B. | 01/28/2017 |
| Suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in esophageal squamous cell carcinoma. | Methyl-methanesulfonate sensitivity 19 expression is associated with metastasis and chemoradiotherapy response in esophageal cancer.
Zhang JL, Wang HY, Yang Q, Lin SY, Luo GY, Zhang R, Xu GL., Free PMC Article | 01/30/2016 |
| MMS19L polymorphisms are associated with response to chemotherapy in osteosarcoma. | Predictive impact of common variations in DNA repair genes on clinical outcome of osteosarcoma.
Bai SB, Chen HX, Bao YX, Luo X, Zhong JJ. | 02/22/2014 |
| Single nucleotide polymorphisms in the MMS19L gene is associated with bone malignant tumors. | Single nucleotide polymorphisms in the NER pathway and clinical outcome of patients with bone malignant tumors.
Sun XH, Hou WG, Zhao HX, Zhao YL, Ma C, Liu Y. | 01/11/2014 |
| Polymorphisms in ERCC1, codon-118 and MMS19 genes are not associated with clinical response to platinum or survival. | The role of single nucleotide polymorphisms of the ERCC1 and MMS19 genes in predicting platinum-sensitivity, progression-free and overall survival in advanced epithelial ovarian cancer.
Moxley KM, Benbrook DM, Queimado L, Zuna RE, Thompson D, McCumber M, Premkumar P, Thavathiru E, Hines L, Moore KN. | 09/14/2013 |
| MMS19 interacts with target proteins. MIP18 has a role to bridge MMS19 and CIAO1. CIAO1 also binds IOP1. | IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.
Seki M, Takeda Y, Iwai K, Tanaka K., Free PMC Article | 08/31/2013 |
| The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. | The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
van Wietmarschen N, Moradian A, Morin GB, Lansdorp PM, Uringa EJ., Free PMC Article | 03/2/2013 |
| identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery; MMS19 functions as part of the CIA targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance | MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Stehling O, Vashisht AA, Mascarenhas J, Jonsson ZO, Sharma T, Netz DJ, Pierik AJ, Wohlschlegel JA, Lill R., Free PMC Article | 11/24/2012 |
| study demonstrates MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA) proteins CIAO1, IOP1 and MIP18; cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair | MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism.
Gari K, León Ortiz AM, Borel V, Flynn H, Skehel JM, Boulton SJ. | 11/24/2012 |
| Results indicate that the MMS19-XPD protein complex is required for proper chromosome segregation, an abnormality of which could contribute to the pathogenesis in some cases of xeroderma pigmentosum. | MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Ito S, Tan LJ, Andoh D, Narita T, Seki M, Hirano Y, Narita K, Kuraoka I, Hiraoka Y, Tanaka K. | 09/27/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesVariation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. | 12/2/2009 |
| Single nucleotide polymorphisms in MMS19L is associated with pancreatic cancer. | Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Cunningham JM, Petersen GM, McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Cunningham JM, Petersen GM., Free PMC Articles: PMC2710767, PMC2710767 | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Cunningham JM, Petersen GM, McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Cunningham JM, Petersen GM., Free PMC Articles: PMC2710767, PMC2710767 | 04/8/2009 |
| Cloning of the human MMS19 genes and functional complementation in Saccharomyces cerevisiae | Cloning the human and mouse MMS19 genes and functional complementation of a yeast mms19 deletion mutant.
Queimado L, Rao M, Schultz RA, Koonin EV, Aravind L, Nardo T, Stefanini M, Friedberg EC., Free PMC Article | 01/21/2010 |
| MMS19 HEAT repeat domain is essential for MMS19 function in NER and transcription, while domains A and B, within MMS19 N-terminus, modulate the balance between DNA repair and transcription. | Identification of MMS19 domains with distinct functions in NER and transcription.
Hatfield MD, Reis AM, Obeso D, Cook JR, Thompson DM, Rao M, Friedberg EC, Queimado L. | 01/21/2010 |