| Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ. | Paraspeckle-independent co-transcriptional regulation of nuclear microRNA biogenesis by SFPQ.
Thivierge C, Bellefeuille M, Diwan SS, Dyakov BJA, Leventis R, Perron G, Najafabadi HS, Gravel SP, Gingras AC, Duchaine TF. | 10/2/2024 |
| SFPQ promotes an oncogenic transcriptomic state in melanoma. | SFPQ promotes an oncogenic transcriptomic state in melanoma.
Bi O, Anene CA, Nsengimana J, Shelton M, Roberts W, Newton-Bishop J, Boyne JR., Free PMC Article | 08/29/2024 |
| The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression. | The nucleic acid binding protein SFPQ represses EBV lytic reactivation by promoting histone H1 expression.
Murray-Nerger LA, Lozano C, Burton EM, Liao Y, Ungerleider NA, Guo R, Gewurz BE., Free PMC Article | 08/13/2024 |
| SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway. | SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
Liu MH, Lin XL, Xiao LL. | 01/26/2024 |
| Splicing factor proline- and glutamine-rich regulates cytotoxic T lymphocytes-mediated cytotoxicity on non-small cell lung cancer by directly binding to PD-L1 3'UTR. | Splicing factor proline- and glutamine-rich regulates cytotoxic T lymphocytes-mediated cytotoxicity on non-small cell lung cancer by directly binding to PD-L1 3'UTR.
Pan Y, Cheng Y., Free PMC Article | 11/18/2023 |
| SFPQ and Its Isoform as Potential Biomarker for Non-Small-Cell Lung Cancer. | SFPQ and Its Isoform as Potential Biomarker for Non-Small-Cell Lung Cancer.
Yang L, Gilbertsen A, Jacobson B, Pham J, Fujioka N, Henke CA, Kratzke RA., Free PMC Article | 08/14/2023 |
| Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. | Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons.
Widagdo J, Udagedara S, Bhembre N, Tan JZA, Neureiter L, Huang J, Anggono V, Lee M., Free PMC Article | 10/8/2022 |
| Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1. | Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.
Wang J, Sachpatzidis A, Christian TD, Lomakin IB, Garen A, Konigsberg WH. | 10/1/2022 |
| Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism. | Molecular Modelling of NONO and SFPQ Dimerization Process and RNA Recognition Mechanism.
Laurenzi T, Palazzolo L, Taiana E, Saporiti S, Ben Mariem O, Guerrini U, Neri A, Eberini I., Free PMC Article | 08/6/2022 |
| ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ. | ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.
Rayner SL, Cheng F, Hogan AL, Grima N, Yang S, Ke YD, Au CG, Morsch M, De Luca A, Davidson JM, Molloy MP, Shi B, Ittner LM, Blair I, Chung RS, Lee A. | 03/5/2022 |
| The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals. | The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals.
Stagsted LVW, O'Leary ET, Ebbesen KK, Hansen TB., Free PMC Article | 02/5/2022 |
| SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72. | SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72.
Malnar M, Rogelj B., Free PMC Article | 07/24/2021 |
| SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference. | SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference.
Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen PR. | 07/3/2021 |
| Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. | Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA., Free PMC Article | 05/22/2021 |
| SFPQ Depletion Is Synthetically Lethal with BRAF(V600E) in Colorectal Cancer Cells. | SFPQ Depletion Is Synthetically Lethal with BRAF(V600E) in Colorectal Cancer Cells.
Klotz-Noack K, Klinger B, Rivera M, Bublitz N, Uhlitz F, Riemer P, Lüthen M, Sell T, Kasack K, Gastl B, Ispasanie SSS, Simon T, Janssen N, Schwab M, Zuber J, Horst D, Blüthgen N, Schäfer R, Morkel M, Sers C. | 05/8/2021 |
| The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration. | The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration.
Lim YW, James D, Huang J, Lee M., Free PMC Article | 02/27/2021 |
| AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma. | AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma.
He SW, Xu C, Li YQ, Li YQ, Zhao Y, Zhang PP, Lei Y, Liang YL, Li JY, Li Q, Chen Y, Huang SY, Ma J, Liu N., Free PMC Article | 12/5/2020 |
| Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity. | Splicing factor proline- and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity.
Pellarin I, Dall'Acqua A, Gambelli A, Pellizzari I, D'Andrea S, Sonego M, Lorenzon I, Schiappacassi M, Belletti B, Baldassarre G., Free PMC Article | 12/5/2020 |
| we propose that dysregulation of zinc availability and/or localization in neuronal cells may represent a mechanism for the imbalance in the nucleocytoplasmic distribution of SFPQ, which is an emerging hallmark of neurodegenerative diseases including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) | Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ.
Huang J, Ringuet M, Whitten AE, Caria S, Lim YW, Badhan R, Anggono V, Lee M., Free PMC Article | 05/23/2020 |
| Dido3 is an adaptor that controls SFPQ utilization in RNA splicing | Dido3-dependent SFPQ recruitment maintains efficiency in mammalian alternative splicing.
Mora Gallardo C, Sánchez de Diego A, Gutiérrez Hernández J, Talavera-Gutiérrez A, Fischer T, Martínez-A C, van Wely KHM., Free PMC Article | 12/7/2019 |
| The protein binding study identified the association of host protein Polypyrimidine tract binding protein and associated splicing factor (PSF) with HIV-1 integrase. Thus our study emphasizes the negative influence of PSF on HIV-1 replication. | Interaction of HIV-1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV-1 replication.
Yadav P, Sur S, Desai D, Kulkarni S, Sharma V, Tandon V., Free PMC Article | 07/20/2019 |
| Findings suggest a PARP polymerase (PARP)-dependent role for non-POU domain containing, octamer-binding protein NONO (NONO) and splicing factor proline-glutamine rich protein (SFPQ) in insulin-like growth factor binding protein 3 (IGFBP-3)-dependent DNA double-strand break (DSB) repair. | IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.
de Silva HC, Lin MZ, Phillips L, Martin JL, Baxter RC., Free PMC Article | 06/1/2019 |
| SFPQ dislocation was found enhanced with tau co-transfection and tau co-transfection further resulted in extended DNA disorganization in N2a cells. Overall, our results indicate that dysregulation and dislocation of SFPQ and subsequent DNA disorganization might be a novel pathway in the progression of Alzheimer's disease and frontotemporal dementia. | Dysregulation and Dislocation of SFPQ Disturbed DNA Organization in Alzheimer's Disease and Frontotemporal Dementia.
Lu J, Shu R, Zhu Y. | 01/26/2019 |
| Analytical ultracentrifugation to estimate the dimerization equilibrium of the SFPQ-containing dimers revealed that the SFPQ-containing dimers dissociate at low micromolar concentrations and that the heterodimers have higher affinities than the homodimer. Moreover, we observed that the apparent dissociation constant for the SFPQ/PSPC1 heterodimer was over 6-fold lower than that of the SFPQ/NONO heterodimer. | Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins.
Huang J, Casas Garcia GP, Perugini MA, Fox AH, Bond CS, Lee M., Free PMC Article | 12/29/2018 |
| SFPQ intron retention and nuclear loss are molecular hallmarks of familial and sporadic of amyotrophic lateral sclerosis. | Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
Luisier R, Tyzack GE, Hall CE, Mitchell JS, Devine H, Taha DM, Malik B, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R., Free PMC Article | 12/22/2018 |