| LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway. | LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
Wu M, Li T, Li G, Niu B, Wu T, Yan L, Wang S, He S, Huang C, Tong W, Li N, Jiang J. | 05/22/2023 |
| DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway. | DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway.
Zhao Y, Zhang M, Dou Y, Du K, Liu X, Zhao Y., Free PMC Article | 05/14/2022 |
| DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. | DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.
Zhao Y, Ma X, Zhou Y, Xie J, Liu X, Zhao Y. | 09/11/2021 |
| DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion. | DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion.
Zhao Y, Zhou Y, Ma X, Liu X, Zhao Y, Liu X. | 12/5/2020 |
| These data suggest that in C6 gliomas DDAH has no NO-independent effects on tumour growth and angiogenesis, and that the therapeutic potential of targeting DDAH in gliomas should only be considered in the context of NO regulation. | Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.
Papaevangelou E, Boult JKR, Whitley GS, Robinson SP, Howe FA., Free PMC Article | 10/26/2019 |
| Fluid reabsorption in the proximal tubule is reduced by tubular ADMA or by blocking its metabolism by DDAH-1. | Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.
Bell T, Araujo M, Luo Z, Tomlinson J, Leiper J, Welch WJ, Wilcox CS., Free PMC Article | 07/20/2019 |
| IFX treatment was associated with an improvement in eNOS activity and increased L-arginine/ADMA ratio and DDAH1 expression. | Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats.
Balasubramanian V, Mehta G, Jones H, Sharma V, Davies NA, Jalan R, Mookerjee RP., Free PMC Article | 07/20/2019 |
| Data show that interleukin-10 (IL-10) attenuates angiotensin II-induced dimethylarginine dimethylaminohydrolase (DDAH-1) inhibition in spontaneously hypertensive rats vascular smooth muscle cells. | Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats.
Kim HY, Kim HS. | 09/17/2016 |
| after cholestasis an increase in hepatic ADMA in RL and ML was detected as well as tissue MMP-2 and MMP-9 activation in RL, supporting the evidence of functional heterogeneity among the liver lobes also occurring in an obstructive cholestasis model. | Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Ferrigno A, Palladini G, Bianchi A, Rizzo V, Di Pasqua LG, Perlini S, Richelmi P, Vairetti M., Free PMC Article | 04/4/2015 |
| The observed antihypertensive effects of NAC in young SHR might be due to restoration of DDAH activity to reduce ADMA, leading to attenuation of oxidative stress | N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.
Fan NC, Tsai CM, Hsu CN, Huang LT, Tain YL., Free PMC Article | 08/9/2014 |
| Pharmacological and genetic reduction of DDAH1 activity is protective against the vascular changes observed during endotoxic shock. | Genetic and pharmacological inhibition of dimethylarginine dimethylaminohydrolase 1 is protective in endotoxic shock.
Nandi M, Kelly P, Torondel B, Wang Z, Starr A, Ma Y, Cunningham P, Stidwill R, Leiper J. | 01/5/2013 |
| PRMT1 and DDAH-1, responsible for the biosynthesis and degradation of asymmetric dimethylarginine respectively, are expressed in erythrocytes, leukocytes, and platelets. | Asymmetric dimethylarginine, an endogenous NOS inhibitor, is actively metabolized in rat erythrocytes.
Yokoro M, Suzuki M, Murota K, Otsuka C, Yamashita H, Takahashi Y, Tsuji H, Kimoto M. | 12/8/2012 |
| DDAH1 is an important mediator of tumour progression, but appears to have addition roles independent of its metabolism of ADMA | Active site mutant dimethylarginine dimethylaminohydrolase 1 expression confers an intermediate tumour phenotype in C6 gliomas.
Boult JK, Walker-Samuel S, Jamin Y, Leiper JM, Whitley GS, Robinson SP. | 12/3/2011 |
| Cerebral enzymatic activities, mRNA and protein expression of arginase and DDAH were determined in African trypanosomiasis model of rat. | Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.
Amrouni D, Meiller A, Gautier-Sauvigné S, Piraud M, Bouteille B, Vincendeau P, Buguet A, Cespuglio R., Free PMC Article | 07/9/2011 |
| In healthy hearts, DDAH I is absent and DDAH II is localized to endothelium and endocardium, with a similar distribution to that of eNOS. The levels and activity of DDAH I and DDAH II are increased following myocardial infarction. | Immunolocalisation and activity of DDAH I and II in the heart and modification post-myocardial infarction.
Gray GA, Patrizio M, Sherry L, Miller AA, Malaki M, Wallace AF, Leiper JM, Vallance P. | 02/26/2011 |
| Results suggest that alterations in DDAH-1/Nos inhibitors/NO-dependent cyclic GMP/ET-1 pathway are possibly involved in maintaining myometrial quiescence during gestation and controlling delivery at term. | Regulation of myometrial contractivity during pregnancy in the rat: potential role for DDAH.
Ito E, Obayashi S, Nagai A, Imamura M, Azuma H. | 01/21/2010 |
| These findings suggest that the modulation of the DDAH/ADMA/ROS pathway plays an important role in CoCl(2)-induced apoptosis and the antiapoptotic effects of atRA in undifferentiated PC12 cells. | All-trans retinoic acid inhibits cobalt chloride-induced apoptosis in PC12 cells: role of the dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine pathway.
Wang S, Hu CP, Jiang DJ, Peng J, Zhou Z, Yuan Q, Nie SD, Jiang JL, Li YJ, Huang KL. | 01/21/2010 |
| Kidney enzyme levels are increased in experimental diabetes. | Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers.
Onozato ML, Tojo A, Leiper J, Fujita T, Palm F, Wilcox CS. | 01/21/2010 |
| asymmetric dimethylarginine is metabolized by DDAH-1, which is strongly in kidney cortex and liver. | Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO.
Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, Mendonca M, Dennehy K, Li M, Modlinger P, Leiper J, Vallance P, Adler O, Leone A, Tojo A, Welch WJ, Wilcox CS. | 01/21/2010 |
| Decreased DDAH activity and elevated endogenous asymmetric dimethylarginine is implicated in endothelial dysfunction of rats exposed to glycosylated bovine serum albumin | Dimethylarginine dimethylaminohydrolase inhibition and asymmetric dimethylarginine accumulation contribute to endothelial dysfunction in rats exposed to glycosylated protein: effects of aminoguanidine.
Yin QF, Fu SH, He P, Xiong Y. | 01/21/2010 |
| Substitution of DDAH protein or enhancement of its activity may become a novel therapeutic strategy for the treatment of chronic kidney disease. | Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease.
Matsumoto Y, Ueda S, Yamagishi S, Matsuguma K, Shibata R, Fukami K, Matsuoka H, Imaizumi T, Okuda S. | 01/21/2010 |
| nicotine modulates DDAH/ADMA/NOS pathway of endothelial cell via activation of alpha7 nAChR, which may be involved in endothelial dysfunction associated to smoking | Involvement of DDAH/ADMA/NOS pathway in nicotine-induced endothelial dysfunction.
Jiang DJ, Jia SJ, Yan J, Zhou Z, Yuan Q, Li YJ. | 01/21/2010 |
| The DDAH1 mRNA expression in the embryonic spinal cord, which was especially strong in the ventral horn and dorsal root ganglion (DRG). DDAH1 was also detected in the brain, kidney, digestive tract, and in other tissues. | Expression of DDAH1 in chick and rat embryos.
Mishima T, Hamada T, Ui-Tei K, Takahashi F, Miyata Y, Imaki J, Suzuki H, Yamashita K. | 01/21/2010 |
| Transfected into glioma cells in nude mice increases cell hypoxia and points to an inverse relationship of tumor oxygenation and angiogenesis in vivo. | Overexpression of dimethylarginine dimethylaminohydrolase enhances tumor hypoxia: an insight into the relationship of hypoxia and angiogenesis in vivo.
Kostourou V, Troy H, Murray JF, Cullis ER, Whitley GS, Griffiths JR, Robinson SP., Free PMC Article | 01/21/2010 |
| The DDAH activity and DDAH1, but not DDAH2, protein expression were significantly reduced in pulmonary artery endothelial cells of rats given monocrotaline | Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats.
Sasaki A, Doi S, Mizutani S, Azuma H. | 01/21/2010 |