| FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment. | FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inflammatory Microenvironment.
Huang Q, Sun Y, Huang W, Zhang F, He H, He Y, Huang F., Free PMC Article | 05/13/2024 |
| MicroRNA-19a-3p Acts as an Oncogene in Gastric Cancer and Exerts the Effect by Targeting SMOC2. | MicroRNA-19a-3p Acts as an Oncogene in Gastric Cancer and Exerts the Effect by Targeting SMOC2.
Xu H, Lu G, Zhou S, Fang F. | 09/3/2022 |
| SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin. | SMOC2 promotes an epithelial-mesenchymal transition and a pro-metastatic phenotype in epithelial cells of renal cell carcinoma origin.
Feng D, Gao P, Henley N, Dubuissez M, Chen N, Laurin LP, Royal V, Pichette V, Gerarduzzi C., Free PMC Article | 08/6/2022 |
| Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma. | Prognostic and clinicopathological significance of TMEFF2, SMOC-2, and SOX17 expression in endometrial carcinoma.
Alabiad MA, Harb OA, Hefzi N, Ahmed RZ, Osman G, Shalaby AM, Alnemr AA, Saraya YS. | 12/25/2021 |
| The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer. | The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer.
Hyun CL, Park SJ, Kim HS, Song HJ, Kim HU, Lee C, Lee DH, Maeng YH, Kim YS, Jang B. | 07/10/2021 |
| SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers. | SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers.
Jang BG, Kim HS, Bae JM, Kim WH, Kim HU, Kang GH., Free PMC Article | 03/28/2021 |
| Downregulation of SMOC2 expression in papillary thyroid carcinoma and its prognostic significance. | Downregulation of SMOC2 expression in papillary thyroid carcinoma and its prognostic significance.
Kim HS, Choi JH, Lee JY, Kang J, Myung JK, Kim WH, Jang BG., Free PMC Article | 12/5/2020 |
| SMOC2 expression was markedly up-regulated in human liver samples with non-alcoholic fatty liver disease. | Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.
Yuting Y, Lifeng F, Qiwei H. | 10/12/2019 |
| we conclude that SMOC-2 might be a novel endometrial cancer stem cell signature gene and therapeutic target for endometrial cancer. | Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma.
Lu H, Ju DD, Yang GD, Zhu LY, Yang XM, Li J, Song WW, Wang JH, Zhang CC, Zhang ZG, Zhang R., Free PMC Article | 06/29/2019 |
| SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders. | SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.
Peeters T, Monteagudo S, Tylzanowski P, Luyten FP, Lories R, Cailotto F., Free PMC Article | 01/19/2019 |
| SMOC2 was highly expressed in both peritoneal and endometrioma lesions. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue. | Increased expression of ID2, PRELP and SMOC2 genes in patients with endometriosis.
Araujo FM, Meola J, Rosa-E-Silva JC, Paz CCP, Ferriani RA, Nogueira AA., Free PMC Article | 11/25/2017 |
| The expression of Smoc2 was significantly higher in hepatocellular carcinoma (HCC) tissues compared with corresponding non-tumor liver tissues. Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression. | Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression.
Su JR, Kuai JH, Li YQ., Free PMC Article | 06/10/2017 |
| L1-mediated CRC progression involves the acquisition of a stem cell-like phenotype, and that SMOC-2 elevation is necessary for L1-mediated induction of more aggressive/invasive CRC properties. | Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.
Shvab A, Haase G, Ben-Shmuel A, Gavert N, Brabletz T, Dedhar S, Ben-Ze'ev A. | 07/30/2016 |
| could not detect an association between SMOC2 gene and AMD. This study tests the candidacy of SMOC2 gene to the etiology of AMD | Lack of association between SMOC2 polymorphism and age-related macular degeneration in Jordanian Arabs.
Alkhateeb AM, Ali AJ, Marzouka NA, Al-Khatib SQ. | 08/29/2015 |
| SMOC2 SNP may play a role in autoimmune thyroid disease susceptibility as a dominant polymorphism. | Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population.
Alkhateeb A, Marzouka NA, Tashtoush R. | 08/9/2014 |
| mutation in exon 8 of the SMOC2 gene linked to oligodontia | Recessive oligodontia linked to a homozygous loss-of-function mutation in the SMOC2 gene.
Alfawaz S, Fong F, Plagnol V, Wong FS, Fearne J, Kelsell DP. | 09/21/2013 |
| Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects | Homozygosity mapping and candidate prioritization identify mutations, missed by whole-exome sequencing, in SMOC2, causing major dental developmental defects.
Bloch-Zupan A, Jamet X, Etard C, Laugel V, Muller J, Geoffroy V, Strauss JP, Pelletier V, Marion V, Poch O, Strahle U, Stoetzel C, Dollfus H., Free PMC Article | 02/4/2012 |
| The variant rs13208776 in SMOC2 gene does not play a major role in increasing the risk of vitiligo in Jordanian Arab patients. | SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs.
Alkhateeb A, Al-Dain Marzouka N, Qarqaz F, Alkhateeb A, Al-Dain Marzouka N, Qarqaz F. | 02/26/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs.
Alkhateeb A, Al-Dain Marzouka N, Qarqaz F, Alkhateeb A, Al-Dain Marzouka N, Qarqaz F. | 12/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| SMOC2 is a risk locus for generalized vitiligo and perhaps other autoimmune diseases | Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
Birlea SA, Gowan K, Fain PR, Spritz RA, Birlea SA, Gowan K, Fain PR, Spritz RA., Free PMC Articles: PMC3511589, PMC3511589 | 03/22/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
Birlea SA, Gowan K, Fain PR, Spritz RA, Birlea SA, Gowan K, Fain PR, Spritz RA., Free PMC Articles: PMC3511589, PMC3511589 | 12/2/2009 |
| Although this study specifies rat, the authors studied and discussed the human gene in this study as well. | Identification of a novel smooth muscle associated protein, smap2, upregulated during neointima formation in a rat carotid endarterectomy model.
Nishimoto S, Hamajima Y, Toda Y, Toyoda H, Kitamura K, Komurasaki T. | 10/22/2009 |
| identification of gene, chromosome mapping | Characterization of SMOC-2, a modular extracellular calcium-binding protein.
Vannahme C, Gösling S, Paulsson M, Maurer P, Hartmann U., Free PMC Article | 01/21/2010 |
| SMOC-2 is a novel angiogenic factor that potentiates angiogenic effects of growth factors | The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity.
Rocnik EF, Liu P, Sato K, Walsh K, Vaziri C. | 01/21/2010 |