| LHPP promotes the intracellular reactive oxygen species accumulation and sensitivity of gastric cancer to cisplatin via JNK and p38 MAPK pathways. | LHPP promotes the intracellular reactive oxygen species accumulation and sensitivity of gastric cancer to cisplatin via JNK and p38 MAPK pathways.
Gao K, Yin N, Shen Z, Li Q, Chen P, Yang K. | 10/23/2023 |
| Identification of Tumor Suppressor Gene LHPP-Based 5-microRNA Signature That Predicts the Early- and Midstage Esophageal Squamous Cell Carcinoma: A Two-Stage Case-Control Study in the Chinese Han Population. | Identification of Tumor Suppressor Gene LHPP-Based 5-microRNA Signature That Predicts the Early- and
Midstage Esophageal Squamous Cell Carcinoma:
A Two-Stage Case-Control Study in the Chinese Han Population.
Zhao X, Zhu X, Wang L, Chen Y, Chen R, Zheng Z, Yang H, Xia W, Yao J, Zhao K. | 07/17/2023 |
| LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p. | LHPP Inhibits the Viability, Migration, and Proliferation of PDAC Cells and Significantly Affects the Expression of SDC1 and S100p.
Xia Z, Zhao S, Gao X, Sun H, Yang F, Zhu H, Gao H, Lu J, Zhou X., Free PMC Article | 06/24/2023 |
| Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines. | Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines.
Ma L, Sun H, Xu X, Chen Y, Zhang L, Li S, Tang L. | 12/3/2022 |
| As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma. | As a Novel Tumor Suppressor, LHPP Promotes Apoptosis by Inhibiting the PI3K/AKT Signaling Pathway in Oral Squamous Cell Carcinoma.
Liu S, Gao W, Lu Y, Zhou Q, Su R, Hasegawa T, Du J, Li M., Free PMC Article | 03/26/2022 |
| Three LHPP gene-targeting co-expressed microRNAs (microRNA-765, microRNA-21, and microRNA-144) promote proliferation, epithelial-mesenchymal transition, invasion, and are independent prognostic biomarkers in renal cell carcinomas patients. | Three LHPP gene-targeting co-expressed microRNAs (microRNA-765, microRNA-21, and microRNA-144) promote proliferation, epithelial-mesenchymal transition, invasion, and are independent prognostic biomarkers in renal cell carcinomas patients.
Meng K, Li Z, Cui X., Free PMC Article | 03/12/2022 |
| LHPP exerts a tumor-inhibiting role in glioblastoma via the downregulation of Akt and Wnt/beta-catenin signaling. | LHPP exerts a tumor-inhibiting role in glioblastoma via the downregulation of Akt and Wnt/β-catenin signaling.
Li C, Yang J, Wang W, Li R. | 12/25/2021 |
| LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFbeta/smad signaling pathway. | LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGFβ/smad signaling pathway.
Wang D, Ning Z, Zhu Z, Zhang C, Wang P, Meng Z. | 09/25/2021 |
| Prognostic Correlation of Glycolysis-Related Gene Signature in Patients with Laryngeal Cancer. | Prognostic Correlation of Glycolysis-Related Gene Signature in Patients with Laryngeal Cancer.
Ding Z, Yu D, Li H, Ding Y. | 09/18/2021 |
| LHPP inhibits hepatocellular carcinoma cell growth and metastasis. | LHPP inhibits hepatocellular carcinoma cell growth and metastasis.
Liao L, Duan D, Liu Y, Chen L., Free PMC Article | 09/4/2021 |
| Purpurin binding interacts with LHPP protein that inhibits PI3K/AKT phosphorylation and induces apoptosis in colon cancer cells HCT-116. | Purpurin binding interacts with LHPP protein that inhibits PI3K/AKT phosphorylation and induces apoptosis in colon cancer cells HCT-116.
Li Z, Zhou X, Zhu H, Song X, Gao H, Niu Z, Lu J. | 07/17/2021 |
| LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma. | LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma.
Zhang X, Kang H, Xiao J, Shi B, Li X, Chen G., Free PMC Article | 05/29/2021 |
| Association of LHPP genetic variation (rs35936514) with structural and functional connectivity of hippocampal-corticolimbic neural circuitry. | Association of LHPP genetic variation (rs35936514) with structural and functional connectivity of hippocampal-corticolimbic neural circuitry.
Cui L, Gong X, Chang M, Yin Z, Geng H, Song Y, Lv J, Feng R, Wang F, Tang Y, Xu K. | 05/8/2021 |
| LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer. | LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Wu F, Chen Y, Zhu J., Free PMC Article | 03/27/2021 |
| LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway. | LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway.
Sun W, Qian K, Guo K, Chen L, Xiang J, Li D, Wu Y, Ji Q, Sun T, Wang Z. | 01/9/2021 |
| Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma. | Clinical value of LHPP-associated microRNAs combined with protein induced by vitamin K deficiency or antagonist-II in the diagnosis of alpha-fetoprotein-negative hepatocellular carcinoma.
Tian Z, Yu T, Wei H, Ning N., Free PMC Article | 12/19/2020 |
| LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway. | LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Li Y, Zhang X, Zhou X, Zhang X., Free PMC Article | 09/12/2020 |
| Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway. | Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D., Free PMC Article | 08/22/2020 |
| LHPP suppresses cell proliferation and metastasis in cervical cancer, and promotes apoptosis by suppressing AKT activation. | Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT.
Zheng J, Dai X, Chen H, Fang C, Chen J, Sun L. | 12/22/2018 |
| in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival; thus LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic | The protein histidine phosphatase LHPP is a tumour suppressor.
Hindupur SK, Colombi M, Fuhs SR, Matter MS, Guri Y, Adam K, Cornu M, Piscuoglio S, Ng CKY, Betz C, Liko D, Quagliata L, Moes S, Jenoe P, Terracciano LM, Heim MH, Hunter T, Hall MN., Free PMC Article | 08/18/2018 |
| LHPP is associated with the interplay of risky sexual behaviors and alcohol dependence. | The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.
Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J., Free PMC Article | 01/20/2018 |
| Patients with major depressive disorder with LHPP rs35936514 CT/TT genotype have increased activity in certain brain regions. | Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder.
Cui L, Gong X, Tang Y, Kong L, Chang M, Geng H, Xu K, Wang F., Free PMC Article | 09/23/2017 |
| LHPP gene variation is associated with oral cavity and pharyngeal cancer. | Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.
Lesseur C, Diergaarde B, Olshan AF, Wünsch-Filho V, Ness AR, Liu G, Lacko M, Eluf-Neto J, Franceschi S, Lagiou P, Macfarlane GJ, Richiardi L, Boccia S, Polesel J, Kjaerheim K, Zaridze D, Johansson M, Menezes AM, Curado MP, Robinson M, Ahrens W, Canova C, Znaor A, Castellsagué X, Conway DI, Holcátová I, Mates D, Vilensky M, Healy CM, Szeszenia-Dąbrowska N, Fabiánová E, Lissowska J, Grandis JR, Weissler MC, Tajara EH, Nunes FD, de Carvalho MB, Thomas S, Hung RJ, Peters WH, Herrero R, Cadoni G, Bueno-de-Mesquita HB, Steffen A, Agudo A, Shangina O, Xiao X, Gaborieau V, Chabrier A, Anantharaman D, Boffetta P, Amos CI, McKay JD, Brennan P., Free PMC Article | 09/9/2017 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression | Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.
Neff CD, Abkevich V, Packer JC, Chen Y, Potter J, Riley R, Davenport C, DeGrado Warren J, Jammulapati S, Bhathena A, Choi WS, Kroeger PE, Metzger RE, Gutin A, Skolnick MH, Shattuck D, Katz DA. | 01/21/2010 |