| Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion. | Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion.
Lin H, Zhang J, Dai Y, Liu H, He X, Chen L, Tao J, Li C, Liu W., Free PMC Article | 02/13/2023 |
| The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet. | The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.
Braun JL, Ryoo J, Goodwin K, Copeland EN, Geromella MS, Baranowski RW, MacPherson REK, Fajardo VA., Free PMC Article | 09/17/2022 |
| Neurogranin inhibits calcineurin in murine soleus muscle: Effects of heterozygous knockdown on muscle adaptations to tenotomy and fatigue resistance. | Neurogranin inhibits calcineurin in murine soleus muscle: Effects of heterozygous knockdown on muscle adaptations to tenotomy and fatigue resistance.
Baranowski RW, Braun JL, Vandenboom R, Fajardo VA. | 08/27/2022 |
| Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice. | Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice.
Nakajima R, Hattori S, Funasaka T, Huang FL, Miyakawa T., Free PMC Article | 11/13/2021 |
| Neurogranin is expressed in skeletal muscle where it is a novel regulator of calcineurin signaling. | Neurogranin is expressed in mammalian skeletal muscle and inhibits calcineurin signaling and myoblast fusion.
Fajardo VA, Watson CJF, Bott KN, Moradi F, Maddalena LA, Bellissimo CA, Turner KD, Peters SJ, LeBlanc PJ, MacNeil AJ, Stuart JA, Tupling AR. | 04/11/2020 |
| lack of Ng in mice decreases prepulse inhibition (PPI). Ng over-expression in the prefrontal cortex (PFC) increases PPI, while Ng expression in either the nucleus accumbens (NAc) or hippocampus induces no change in PPI. | Neurogranin regulates sensorimotor gating through cortico-striatal circuitry.
Sullivan JM 3rd, Grant CA, Reker AN, Nahar L, Goeders NE, Nam HW., Free PMC Article | 01/25/2020 |
| Myeloid SIRT1 knockout (KO) mice exhibited higher food intake, weight gain, and lower expression of anorexigenic proopiomelanocortin in the arcuate nucleus than WT mice. In particular, KO mice had lower ventromedial hypothalamus (VMH)-specific neurogranin expression. | Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
Kim KE, Jeong EA, Shin HJ, Lee JY, Choi EB, An HS, Park KA, Jin Z, Lee DK, Horvath TL, Roh GS. | 06/8/2019 |
| The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling. | Neurogranin in the nucleus accumbens regulates NMDA receptor tolerance and motivation for ethanol seeking.
Reker AN, Oliveros A, Sullivan JM 3rd, Nahar L, Hinton DJ, Kim T, Bruner RC, Choi DS, Goeders NE, Nam HW. | 11/17/2018 |
| The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks. | Increased prefrontal cortex neurogranin enhances plasticity and extinction learning.
Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ., Free PMC Article | 08/1/2015 |
| Neurogranin knockout mice are hyperactive and socially withdrawn. | Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice.
Huang FL, Huang KP., Free PMC Article | 03/16/2013 |
| Ng expression in olfactory bulb is restricted to developmental stages suggesting activity-dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells. | Transitory and activity-dependent expression of neurogranin in olfactory bulb tufted cells during mouse postnatal development.
Gribaudo S, Bovetti S, Friard O, Denorme M, Oboti L, Fasolo A, De Marchis S. | 03/9/2013 |
| findings suggest that mobilization of CaM and Ng to stimulated dendritic spines may enhance synaptic efficacy by increasing and prolonging the Ca2+ transients and activation of Ca2+/CaM-dependent enzymes. | Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons.
Huang KP, Huang FL, Shetty PK., Free PMC Article | 07/2/2011 |
| We propose that the differential regulation of multiple sense and novel overlapping natural antisense transcripts at the Nrgn and Camk2n1 loci will increase the diversity of posttranscriptional regulation | Spatiotemporal regulation of multiple overlapping sense and novel natural antisense transcripts at the Nrgn and Camk2n1 gene loci during mouse cerebral corticogenesis.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Cheah PS, Smyth GK, Tan SS, Hahn CN, Thomas T, Thomas PQ, Scott HS. | 06/18/2011 |
| Results provide a new specific neurochemical marker to identify a subpopulation of olfactory granule cells and suggest possible functional implications for neurogranin in olfactory bulb plasticity mechanisms. | Expression and localization of the calmodulin-binding protein neurogranin in the adult mouse olfactory bulb.
Gribaudo S, Bovetti S, Garzotto D, Fasolo A, De Marchis S. | 03/1/2010 |
| Data show that Ng displays a strong nuclear localization when expressed in cell lines and hippocampal neurons. | Activity-dependent translocation of neurogranin to neuronal nuclei.
Garrido-García A, Andrés-Pans B, Durán-Trío L, Díez-Guerra FJ. | 01/21/2010 |
| The presented data demonstrate that Nrgn can be produced at high levels outside the brain, and suggest a novel oncogenic role in T-cell lymphomas in mice. | Activation of the brain-specific neurogranin gene in murine T-cell lymphomas by proviral insertional mutagenesis.
Nielsen AA, Kjartansdóttir KR, Rasmussen MH, Sørensen AB, Wang B, Wabl M, Pedersen FS., Free PMC Article | 01/21/2010 |
| Neurogranin may regulate, in addition to the Ca(2+)-CaM-dependent process, Ca(2+)-sensitive enzymes by influencing the buffering capacity of CaM and subsequently free Ca(2+) levels. | IQ-motif proteins influence intracellular free Ca2+ in hippocampal neurons through their interactions with calmodulin.
Kubota Y, Putkey JA, Shouval HZ, Waxham MN., Free PMC Article | 01/21/2010 |
| Neurogranin(Ng) gates neuronal signaling reactions involved in learning and memory. During environmental enrichment, these Ng-regulated reactions are also critical for enhancement of synaptic plasticity and cognitive functions. | Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice.
Huang FL, Huang KP, Wu J, Boucheron C., Free PMC Article | 01/21/2010 |
| long-term enrichment for the aging Ng-/- mice may improve their cognitive function through an Ng-independent plasticity pathway | Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP.
Huang FL, Huang KP, Boucheron C., Free PMC Article | 01/21/2010 |
| NG is expressed by principal cells in different neocortical layers and in the hippocampus by granule cells of the dentate gyrus and pyramidal neurons of CA1-CA3. | Neurogranin is expressed by principal cells but not interneurons in the rodent and monkey neocortex and hippocampus.
Singec I, Knoth R, Ditter M, Volk B, Frotscher M. | 01/21/2010 |
| Neurogranin expression in the cerebellum by brush cells, which are excitatory, shows remarkable cell type- and species-specific expression patterns of a postsynaptic protein mediating calcium signaling mechanisms. | Neurogranin expression by cerebellar neurons in rodents and non-human primates.
Singec I, Knoth R, Ditter M, Frotscher M, Volk B. | 01/21/2010 |
| calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3 | Calcium dynamics are altered in cortical neurons lacking the calmodulin-binding protein RC3.
van Dalen JJ, Gerendasy DD, de Graan PN, Schrama LH, Gruol DL. | 01/21/2010 |
| NMDA induced a rapid and transient phosphorylation and oxidation of neurogranin in mouse hippocampal slices | Participation of NMDA-mediated phosphorylation and oxidation of neurogranin in the regulation of Ca2+- and Ca2+/calmodulin-dependent neuronal signaling in the hippocampus.
Wu J, Huang KP, Huang FL. | 01/21/2010 |
| These results suggest that neurogranin protein may be involved in the development of cerebral hypoxic preconditioning. | Increased phosphorylation of neurogranin in the brain of hypoxic preconditioned mice.
Li J, Yang C, Han S, Zu P, Wu J, Xu Q, Fang L. | 01/21/2010 |
| Results suggest that neurogranin oxidation plays a significant role in intracellular calcium homeostasis, essential for the activated signaling networks in learning and memory. | Neurogranin expression in stably transfected N2A cell line affects cytosolic calcium level by nitric oxide stimulation.
Yang HM, Lee PH, Lim TM, Sheu FS. | 01/21/2010 |