| The Interaction between CLSPN Gene Polymorphisms and Alcohol Consumption Contributes to Oral Cancer Progression. | The Interaction between CLSPN Gene Polymorphisms and Alcohol Consumption Contributes to Oral Cancer Progression.
Hsieh MJ, Lo YS, Ho HY, Lin CC, Chuang YC, Chen MK., Free PMC Article | 02/28/2024 |
| CLSPN is a potential biomarker associated with poor prognosis in low-grade gliomas based on a multi-database analysis. | CLSPN is a potential biomarker associated with poor prognosis in low-grade gliomas based on a multi-database analysis.
Jia Y, Cheng X, Liang W, Lin S, Li P, Yan Z, Zhang M, Ma W, Hu C, Wang B, Liu Z. | 11/26/2022 |
| Overexpression of claspin promotes docetaxel resistance and is associated with prostate-specific antigen recurrence in prostate cancer. | Overexpression of claspin promotes docetaxel resistance and is associated with prostate-specific antigen recurrence in prostate cancer.
Babasaki T, Sentani K, Sekino Y, Kobayashi G, Thang Pham Q, Katsuya N, Akabane S, Taniyama D, Hayashi T, Shiota M, Oue N, Teishima J, Matsubara A, Yasui W., Free PMC Article | 02/19/2022 |
| Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein. | Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein.
Day M, Parry-Morris S, Houghton-Gisby J, Oliver AW, Pearl LH., Free PMC Article | 01/15/2022 |
| circRNA derived from CLSPN (circCLSPN) is an oncogene in human glioblastoma multiforme by regulating cell growth, migration and invasion via ceRNA pathway. | circRNA derived from CLSPN (circCLSPN) is an oncogene in human glioblastoma multiforme by regulating cell growth, migration and invasion via ceRNA pathway.
Hu T, Lei D, Zhou J, Zhang BO. | 01/1/2022 |
| Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes. | Histones on fire: the effect of Dun1 and Mrc1 on origin firing and replication of hyper-acetylated genomes.
Gershon L, Kupiec M. | 09/4/2021 |
| Claspin Overexpression Promotes Tumor Progression and Predicts Poor Clinical Outcome in Prostate Cancer. | Claspin Overexpression Promotes Tumor Progression and Predicts Poor Clinical Outcome in Prostate Cancer.
Cai C, Luo J, Liu Q, Liu Z, Zhao Y, Wu X, Yuegao Y, Lei Y, Lu J, Wang Y, Cai Z, Duan X, Lei M, Gu D, Liu Y. | 07/17/2021 |
| OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress. | OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress.
Feu S, Unzueta F, Llopis A, Semple JI, Ercilla A, Guaita-Esteruelas S, Jaumot M, Freire R, Agell N. | 02/2/2021 |
| Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination. | Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination.
Tu Y, Chen Z, Zhao P, Sun G, Bao Z, Chao H, Fan L, Li C, You Y, Qu Y, Chen Y, Ji J. | 01/23/2021 |
| Posttranscriptional control of the replication stress response via TTP-mediated Claspin mRNA stabilization. | Posttranscriptional control of the replication stress response via TTP-mediated Claspin mRNA stabilization.
Lee TH, Choi JY, Park JM, Kang TH. | 11/28/2020 |
| we show that Cdc7 is required for Claspin-Chk1 interaction in human cancer cells by phosphorylating CKBD (Chk1-binding-domain) of Claspin. | Cdc7 activates replication checkpoint by phosphorylating the Chk1-binding domain of Claspin in human cells.
Yang CC, Kato H, Shindo M, Masai H., Free PMC Article | 06/13/2020 |
| Claspin plays an important role in tumor progression in RCC and might be a prognostic marker and novel therapeutic target molecule. | Claspin overexpression is associated with high-grade histology and poor prognosis in renal cell carcinoma.
Kobayashi G, Sentani K, Babasaki T, Sekino Y, Shigematsu Y, Hayashi T, Oue N, Teishima J, Matsubara A, Sasaki N, Yasui W., Free PMC Article | 03/21/2020 |
| These results indicate that the expression of claspin might be a key regulator in the progression of gastric cancer | Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer.
Kobayashi G, Sentani K, Hattori T, Yamamoto Y, Imai T, Sakamoto N, Kuraoka K, Oue N, Sasaki N, Taniyama K, Yasui W. | 11/16/2019 |
| Claspin is a cell cycle checkpoint adaptor and DNA replication factor. (Review) | Claspin - checkpoint adaptor and DNA replication factor.
Smits VAJ, Cabrera E, Freire R, Gillespie DA. | 08/10/2019 |
| the data indicate that enhanced levels of Claspin and Timeless represent a gain of function that protects cancer cells from oncogene-induced replication stress in a checkpoint-independent manner. | Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner.
Bianco JN, Bergoglio V, Lin YL, Pillaire MJ, Schmitz AL, Gilhodes J, Lusque A, Mazières J, Lacroix-Triki M, Roumeliotis TI, Choudhary J, Moreaux J, Hoffmann JS, Tourrière H, Pasero P., Free PMC Article | 04/6/2019 |
| The functions of claspin are discussed and how its deregulation may contribute to cancer initiation and progression. [REVIEW] | Claspin functions in cell homeostasis-A link to cancer?
Azenha D, Lopes MC, Martins TC. | 12/2/2017 |
| Results unveil a new aspect of PERK function and previously unknown roles for Claspin and Chk1 as negative regulators of DNA replication in the absence of genotoxic stress. | PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.
Cabrera E, Hernández-Pérez S, Koundrioukoff S, Debatisse M, Kim D, Smolka MB, Freire R, Gillespie DA. | 09/30/2017 |
| found that USP9X regulated the expression and stability of CLASPIN in an S-phase-specific manner. USP9X depletion profoundly impairs the progression of DNA replication forks, causing unscheduled termination events with a frequency similar to CLASPIN depletion, resulting in excessive endogenous DNA damage | The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.
McGarry E, Gaboriau D, Rainey MD, Restuccia U, Bachi A, Santocanale C. | 03/4/2017 |
| Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation. | TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases.
Choi SH, Yang H, Lee SH, Ki JH, Nam DH, Yoo HY., Free PMC Article | 05/7/2016 |
| And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. | And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.
Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W., Free PMC Article | 10/31/2015 |
| USP29 interacts with Claspin and is able to deubiquitinate it both in vivo and in vitro. | USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.
Martín Y, Cabrera E, Amoedo H, Hernández-Pérez S, Domínguez-Kelly R, Freire R. | 05/2/2015 |
| Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. | Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y., Free PMC Article | 07/20/2013 |
| findings identify claspin as an in vivo substrate for the BRCA1 E3 ligase and suggest that its modification selectively triggers CHK1 activation for the homology-directed repair of a subset of genotoxic lesions | A DNA-damage selective role for BRCA1 E3 ligase in claspin ubiquitylation, CHK1 activation, and DNA repair.
Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T, Venkitaraman AR. | 04/6/2013 |
| analysis of claspin expression could be clinically relevant in the diagnosis of HPV-related cervical lesions, in particular when applied to cervico-vaginal cytology | Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix.
Benevolo M, Musio A, Vocaturo A, Donà MG, Rollo F, Terrenato I, Carosi M, Pescarmona E, Vocaturo G, Mottolese M., Free PMC Article | 02/23/2013 |
| The conserved C terminus of Claspin interacts with Rad9 and ensures timely activation of the ATR-Chk1 pathway. | The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1.
Liu S, Song N, Zou L., Free PMC Article | 12/8/2012 |