| Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model. | Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model.
Chen C, Xie T, Zhang Y, Wang Y, Yu F, Lin L, Zhang W, Brown BC, Zhang X, Kellems RE, D'Alessandro A, Xia Y., Free PMC Article | 02/8/2024 |
| Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling. | Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
Ruan W, Li J, Choi S, Ma X, Liang Y, Nair R, Yuan X, Mills TW, Eltzschig HK., Free PMC Article | 06/9/2023 |
| Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury. | Equilibrative Nucleoside Transporter 1 is a Target to Modulate Neuroinflammation and Improve Functional Recovery in Mice with Spinal Cord Injury.
Chen KY, Lu CS, Pang CY, Ho CJ, Wu KC, Yang HW, Lai HL, Chern Y, Lin CJ. | 12/31/2022 |
| The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis. | The equilibrative nucleoside transporter ENT1 is critical for nucleotide homeostasis and optimal erythropoiesis.
Mikdar M, González-Menéndez P, Cai X, Zhang Y, Serra M, Dembele AK, Boschat AC, Sanquer S, Chhuon C, Guerrera IC, Sitbon M, Hermine O, Colin Y, Le Van Kim C, Kinet S, Mohandas N, Xia Y, Peyrard T, Taylor N, Azouzi S., Free PMC Article | 12/4/2021 |
| Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms. | Type 1 equilibrative nucleoside transporter (ENT1) regulates sex-specific ethanol drinking during disruption of circadian rhythms.
Jia YF, Vadnie CA, Ho AM, Peyton L, Veldic M, Wininger K, Matveyenko A, Choi DS., Free PMC Article | 08/14/2021 |
| Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth. | Maternal erythrocyte ENT1-mediated AMPK activation counteracts placental hypoxia and supports fetal growth.
Sayama S, Song A, Brown BC, Couturier J, Cai X, Xu P, Chen C, Zheng Y, Iriyama T, Sibai B, Longo M, Kellems RE, D'Alessandro A, Xia Y., Free PMC Article | 05/22/2021 |
| GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism. | GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism.
Zwifelhofer NM, Cai X, Liao R, Mao B, Conn DJ, Mehta C, Keles S, Xia Y, Bresnick EH., Free PMC Article | 01/23/2021 |
| ENT1/2 chemical inhibition and ENT1 knockout prevented P. aeruginosa-induced lung NLRP3 inflammasome activation. | Blockade of equilibrative nucleoside transporter 1/2 protects against Pseudomonas aeruginosa-induced acute lung injury and NLRP3 inflammasome activation.
Chambers ED, White A, Vang A, Wang Z, Ayala A, Weng T, Blackburn M, Choudhary G, Rounds S, Lu Q., Free PMC Article | 07/11/2020 |
| The current study demonstrates that loss of ENT1-mediated adenosine transport leads to increased cell proliferation in the annulus fibrosus of the intervertebral disc | Loss of ENT1 increases cell proliferation in the annulus fibrosus of the intervertebral disc.
Veras MA, Tenn NA, Kuljanin M, Lajoie GA, Hammond JR, Dixon SJ, Séguin CA. | 05/30/2020 |
| The results of this study suggested that binge alcohol consumption-induced down-regulation of ENT1 expression may disrupt sleep homeostasis and cause sleep disturbances | A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis, and down-regulates equilibrative nucleoside transporter 1.
Sharma R, Sahota P, Thakkar MM. | 06/29/2019 |
| Calcification of spinal connective tissues in the ENT1 deficient mouse results in a stiffened spine. | Paraspinal Muscle Passive Stiffness Remodels in Direct Response to Spine Stiffness: A Study Using the ENT1-Deficient Mouse.
Gsell KY, Zwambag DP, Fournier DE, Séguin CA, Brown SHM. | 06/8/2019 |
| Aortas from Slc29a1-null mice respond to hypoxic insult in a manner comparable to wild-type tissues that have been pharmacologically preconditioned with adenosine. The data also support a role for ENT1 in the regulation of the protective effects of adenosine on contractile function in elastic conduit arteries such as thoracic aorta. | Changes in aortic reactivity associated with the loss of equilibrative nucleoside transporter 1 (ENT1) in mice.
Best KA, Bone DB, Vilas G, Gros R, Hammond JR., Free PMC Article | 04/27/2019 |
| These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE complex protein VAMP1 (synaptobrevin-1) in the dHip as well as decreased expression of pro-dynorphin (PDYN), neuroendocrine convertase (PCSK1), and Leu-Enkephalin (dynorphin-A) in the nucleus accumbens | Label-Free Neuroproteomics of the Hippocampal-Accumbal Circuit Reveals Deficits in Neurotransmitter and Neuropeptide Signaling in Mice Lacking Ethanol-Sensitive Adenosine Transporter.
Oliveros A, Starski P, Lindberg D, Choi S, Heppelmann CJ, Dasari S, Choi DS., Free PMC Article | 10/21/2017 |
| Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD. | Targeting ENT1 and adenosine tone for the treatment of Huntington's disease.
Kao YH, Lin MS, Chen CM, Wu YR, Chen HM, Lai HL, Chern Y, Lin CJ. | 09/16/2017 |
| Study suggests that during sleep-wakefulness, type 1 equilibrative nucleoside transporter is necessary for the linear relationship between EEG markers of waking and the following periods of NREMS, and the adenosine is critical for this regulation. | Disrupted sleep-wake regulation in type 1 equilibrative nucleoside transporter knockout mice.
Kim T, Ramesh V, Dworak M, Choi DS, McCarley RW, Kalinchuk AV, Basheer R., Free PMC Article | 05/7/2016 |
| ENBT1 activity is decreased in MVEC in response to the increased superoxide radical that is associated with ischemia/reperfusion injury | Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress.
Bone DB, Antic M, Quinonez D, Hammond JR. | 01/16/2016 |
| results establish Augustine as a new blood group system and place SLC29A1 as a new candidate gene for idiopathic disorders characterized with ectopic calcification/mineralization. | Lack of the nucleoside transporter ENT1 results in the Augustine-null blood type and ectopic mineralization.
Daniels G, Ballif BA, Helias V, Saison C, Grimsley S, Mannessier L, Hustinx H, Lee E, Cartron JP, Peyrard T, Arnaud L., Free PMC Article | 08/15/2015 |
| Findings demonstrate that ENT1 regulates GFAP expression and possibly astrocyte function | Type 1 equilibrative nucleoside transporter regulates astrocyte-specific glial fibrillary acidic protein expression in the striatum.
Hinton DJ, Lee MR, Jang JS, Choi DS., Free PMC Article | 07/25/2015 |
| ENT1-regulated adenosine signaling plays an essential role in lumbar spine and femur bone density | Aberrant bone density in aging mice lacking the adenosine transporter ENT1.
Hinton DJ, McGee-Lawrence ME, Lee MR, Kwong HK, Westendorf JJ, Choi DS., Free PMC Article | 01/3/2015 |
| findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury | Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion.
Zimmerman MA, Tak E, Ehrentraut SF, Kaplan M, Giebler A, Weng T, Choi DS, Blackburn MR, Kam I, Eltzschig HK, Grenz A., Free PMC Article | 03/15/2014 |
| This is the first report of a role for ENT1 in regulating the calcification of soft tissues. ENT1(-/-) mice may be a useful model for investigating pathogenesis and evaluating therapeutics for the prevention of mineralization in DISH and related disord | Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans.
Warraich S, Bone DB, Quinonez D, Ii H, Choi DS, Holdsworth DW, Drangova M, Dixon SJ, Séguin CA, Hammond JR. | 10/19/2013 |
| these findings reveal the transcriptional repression of ENT1,2 as an innate protective response during acute pulmonary inflammation. | Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury.
Morote-Garcia JC, Köhler D, Roth JM, Mirakaj V, Eldh T, Eltzschig HK, Rosenberger P., Free PMC Article | 10/19/2013 |
| It was shown that the responsiveness of kidney tubules and glomeruli is significantly attenuated in the absence of ENT1, leading to changes of extracellular adenosine levels in the juxtaglomerular apparatus interstitium. | Tubuloglomerular feedback and renal function in mice with targeted deletion of the type 1 equilibrative nucleoside transporter.
Li L, Mizel D, Huang Y, Eisner C, Hoerl M, Thiel M, Schnermann J., Free PMC Article | 05/4/2013 |
| This study demonstrated that the A2AR antagonist ZM241385 dampened protein kinase A activity-mediated signaling in the DMS and promoted excessive ethanol drinking in ENT1(+/+) mice | Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum.
Nam HW, Hinton DJ, Kang NY, Kim T, Lee MR, Oliveros A, Adams C, Ruby CL, Choi DS., Free PMC Article | 04/27/2013 |
| Perfusions without sodium drastically reduced the intestinal loss of ribavirin in both wild-type and Ent1(-/-) mice. | Role of the equilibrative and concentrative nucleoside transporters in the intestinal absorption of the nucleoside drug, ribavirin, in wild-type and Ent1(-/-) mice.
Moss AM, Endres CJ, Ruiz-Garcia A, Choi DS, Unadkat JD., Free PMC Article | 03/9/2013 |