| Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease. | Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease.
Cheng J, Zheng H, Liu C, Jin J, Xing Z, Wu Y. | 06/7/2023 |
| High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma. | High Level of Ubiquitin Conjugate Enzyme E2O Indicates Poor Prognosis of Patients with Hepatocellular Carcinoma.
Lan SY, Ding Y, Wang C, Fang J, Ren C, Liu JL, Kang H, Chang Y. | 03/13/2023 |
| Mechanism of client selection by the protein quality-control factor UBE2O. | Mechanism of client selection by the protein quality-control factor UBE2O.
Yip MCJ, Sedor SF, Shao S., Free PMC Article | 08/20/2022 |
| UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKalpha2/mTOR pathway. | UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway.
Shi Z, Liu R, Lu Q, Zeng Z, Liu Y, Zhao J, Liu X, Li L, Huang H, Yao Y, Huang D, Xu Q., Free PMC Article | 03/12/2022 |
| UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. | UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.
Huang Q, Qin D, Pei D, Vermeulen M, Zhang X. | 01/15/2022 |
| UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance. | UBE2O targets Mxi1 for ubiquitination and degradation to promote lung cancer progression and radioresistance.
Huang Y, Yang X, Lu Y, Zhao Y, Meng R, Zhang S, Dong X, Xu S, Wu G., Free PMC Article | 12/18/2021 |
| Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6. | Saliva exosomes-derived UBE2O mRNA promotes angiogenesis in cutaneous wounds by targeting SMAD6.
Mi B, Chen L, Xiong Y, Yan C, Xue H, Panayi AC, Liu J, Hu L, Hu Y, Cao F, Sun Y, Zhou W, Liu G., Free PMC Article | 02/2/2021 |
| UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKalpha2/mTORC1-MYC positive feedback loop. | UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, Li G, Niu Z, Liu J, Chen D, Li Z, Fu Y, Qian C., Free PMC Article | 01/16/2021 |
| Study found that UBE2O is markedly upregulated in obese subjects with type 2 diabetes. | A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity.
Vila IK, Park MK, Setijono SR, Yao Y, Kim H, Badin PM, Choi S, Narkar V, Choi SW, Chung J, Moro C, Song SJ, Song MS., Free PMC Article | 07/25/2020 |
| UBE2O directly mediates the ubiquitination of many substrates, including AMPKalpha2, BAP1, MLL protein SMAD6, c-Maf, ARNTL, and free ribosomal proteins. UBE2O is frequently amplified or mutated in multiple cancers, and its high expression is associated with low survival rate of gastric, lung, breast, and prostate cancer patients. Review. | Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Ullah K, Zubia E, Narayan M, Yang J, Xu G. | 05/9/2020 |
| UBE2O is critical for P-TEFb recruitment to the HIV-1 promoter. | The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.
Faust TB, Li Y, Bacon CW, Jang GM, Weiss A, Jayaraman B, Newton BW, Krogan NJ, D'Orso I, Frankel AD., Free PMC Article | 05/4/2019 |
| This work identifies UBE2O as a critical regulator in the ubiquitin-proteasome system, which modulates BMAL1 transcriptional activity and circadian function by promoting BMAL1 ubiquitination and degradation under normal physiological conditions. | Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.
Chen S, Yang J, Zhang Y, Duan C, Liu Q, Huang Z, Xu Y, Zhou L, Xu G., Free PMC Article | 02/9/2019 |
| UBE2O is a self-contained quality control factor that comprises substrate recognition and ubiquitin transfer activities within a single protein to efficiently target orphans of multiprotein complexes for degradation. | UBE2O is a quality control factor for orphans of multiprotein complexes.
Yanagitani K, Juszkiewicz S, Hegde RS., Free PMC Article | 01/13/2018 |
| UBE2O mediates c-Maf polyubiquitination and degradation, induces MM cell apoptosis, and suppresses myeloma tumor growth, which provides a novel insight in understanding myelomagenesis and UBE2O biology. | The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis.
Xu Y, Zhang Z, Li J, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran MF, Zeng Y, Mao X., Free PMC Article | 01/6/2018 |
| UBE2O specifically targets AMPKalpha2 for ubiquitination and degradation, and thereby promotes activation of the mTOR-HIF1alpha pathway. | A UBE2O-AMPKα2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy.
Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, González-Billalabeitia E, Hung MC, Song SJ, Song MS., Free PMC Article | 06/10/2017 |
| UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1. | Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O.
Mashtalir N, Daou S, Barbour H, Sen NN, Gagnon J, Hammond-Martel I, Dar HH, Therrien M, Affar el B. | 07/26/2014 |
| UBE2O negatively regulates TRAF6-mediated NF-kappaB activation by inhibiting TRAF6 polyubiquitination. | UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination.
Zhang X, Zhang J, Zhang L, van Dam H, ten Dijke P., Free PMC Article | 09/7/2013 |
| monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O and SMAD6 cooperated in the regulation of BMP7-induced adipogenesis | Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6.
Zhang X, Zhang J, Bauer A, Zhang L, Selinger DW, Lu CX, Ten Dijke P., Free PMC Article | 05/25/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |