| The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From Cell-Cycle Control to NF-kappaB Regulator. | The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From Cell-Cycle Control to NF-κB Regulator.
Gulei D, Drula R, Ghiaur G, Buzoianu AD, Kravtsova-Ivantsiv Y, Tomuleasa C, Ciechanover A. | 06/7/2023 |
| A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-kappaB1 p105 to p50: A potential for a tumor-suppressive PROTAC. | A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.
Goldhirsh G, Kravtsova-Ivantsiv Y, Satish G, Ziv T, Brik A, Ciechanover A., Free PMC Article | 01/22/2022 |
| Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain. | Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.
Rahman MS, Winsvold BS, Chavez Chavez SO, Børte S, Tsepilov YA, Sharapov SZ, HUNT All-In Pain, Aulchenko YS, Hagen K, Fors EA, Hveem K, Zwart JA, van Meurs JB, Freidin MB, Williams FM., Free PMC Article | 09/25/2021 |
| Excess of the NF-kB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms. | Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms.
Kravtsova-Ivantsiv Y, Goldhirsh G, Ivantsiv A, Ben Itzhak O, Kwon YT, Pikarsky E, Ciechanover A., Free PMC Article | 01/23/2021 |
| E3 ubiquitin ligase RNF123 targets LMNB1, Rb protein and LAP2alpha for proteasomal degradation. | E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.
Khanna R, Krishnamoorthy V, Parnaik VK. | 04/13/2019 |
| Findings indicate epigenetic regulation of E3 ubiquitin ligase KPC1 associated with NF-kappa B (NF-kappaB) pathway activation, promoting metastatic melanoma progression. | Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.
Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu S, Nelson N, Kravtsova-Ivantsiv Y, Mills GB, Davies MA, Hoon DSB., Free PMC Article | 05/5/2018 |
| p27 and its cognate ubiquitin ligases, Skp2/KPC/Pirh2, are specifically involved in determining the clinical profiles of lung carcinomas. | Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.
Dobashi Y, Tsubochi H, Minegishi K, Kitagawa M, Otani S, Ooi A. | 10/7/2017 |
| RNF123 functions as a novel inhibitor of innate antiviral signaling mediated by RIG-I and MDA5, a function that does not depend on its E3 ligase activity. | RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.
Wang S, Yang YK, Chen T, Zhang H, Yang WW, Song SS, Zhai ZH, Chen DY., Free PMC Article | 08/19/2017 |
| Suggest that RNF213 R4810K carriers have lower angiogenic capacities, indicating that they might be more susceptible to insults of cerebral hypoxia. | Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.
Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, Imai H, Sone M, Taura D, Harada KH, Habu T, Takagi Y, Miyamoto S, Koizumi A., Free PMC Article | 04/23/2016 |
| Study identified KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling. Overexpression of KPC1 inhibits tumor growth likely mediated via excessive generation of p50. | KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.
Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A. | 07/4/2015 |
| up-regulation of RNF123 was restricted to the cingulate cortex of patients with psychotic manifestations of the depression, supporting the role of the ubiquitin system in psychosis. | Correlative gene expression pattern linking RNF123 to cellular stress-senescence genes in patients with depressive disorder: implication of DRD1 in the cerebral cortex.
Teyssier JR, Rey R, Ragot S, Chauvet-Gelinier JC, Bonin B. | 05/17/2014 |
| The number of patients with moyamoya disease, which is estimated at approximately one per 300 carriers of RNF123 polymorphism p.R4810K, is considered to be 53,800 in East Asian populations. | Distribution of moyamoya disease susceptibility polymorphism p.R4810K in RNF213 in East and Southeast Asian populations.
Liu W, Hitomi T, Kobayashi H, Harada KH, Koizumi A. | 08/3/2013 |
| Our data support a role for RNF123 ubiquitin ligase in the degradation of HP1alpha and HP1beta upon lamin A/C knock-down | Ubiquitin ligase RNF123 mediates degradation of heterochromatin protein 1α and β in lamin A/C knock-down cells.
Chaturvedi P, Khanna R, Parnaik VK., Free PMC Article | 04/6/2013 |
| This study deministrated that genome-wide significant quantitative trait locus was localized on chromsome 4p15 exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the RNF123 gene) and disease risk. | High dimensional endophenotype ranking in the search for major depression risk genes.
Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW Jr, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J., Free PMC Article | 03/31/2012 |
| Dendritic cell apoptosis was at least regulated by miR-221 and miR-155 through targeting the 3'-UTRs of p27kip1 and Kip1 ubiquitination-promoting complex 1 (KPC1), respectively. | miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1.
Lu C, Huang X, Zhang X, Roensch K, Cao Q, Nakayama KI, Blazar BR, Zeng Y, Zhou X., Free PMC Article | 07/16/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Association analysis of 3p21 with Crohn's disease in a New Zealand population.
Morgan AR, Han DY, Lam WJ, Fraser AG, Ferguson LR. | 06/30/2010 |
| KPC thus probably controls degradation of p27(Kip1) in G1 phase after export of the latter from the nucleus | Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.
Kamura T, Hara T, Matsumoto M, Ishida N, Okumura F, Hatakeyama S, Yoshida M, Nakayama K, Nakayama KI. | 01/21/2010 |
| Free p27 is recognized by the amino-terminal region of KPC1, which also associates with KPC2, and p27 is then polyubiquitylated by the carboxy-terminal RING-finger domain of KPC1. | Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.
Kotoshiba S, Kamura T, Hara T, Ishida N, Nakayama KI. | 01/21/2010 |