| SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer. | SDCBP modulates tumor microenvironment, tumor progression and anti-PD1 efficacy in colorectal cancer.
Yu J, Yu S, Bai J, Zhu Z, Gao Y, Li Y. | 08/23/2024 |
| Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells. | Syntenin-1-mediated arthritogenicity is advanced by reprogramming RA metabolic macrophages and Th1 cells.
Meyer A, Sienes RE, Nijim W, Zanotti B, Umar S, Volin MV, Van Raemdonck K, Lewis M, Pitzalis C, Arami S, Al-Awqati M, Chang HJ, Jetanalin P, Schett G, Sweiss N, Shahrara S., Free PMC Article | 10/5/2023 |
| Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1. | Anaplasma phagocytophilum Ats-1 enhances exosome secretion through Syntenin-1.
Li R, Ma Z, Zheng W, Xiao Y, Wang Z, Yi J, Wang Y, Chen C., Free PMC Article | 09/29/2023 |
| SDCBP promotes pancreatic cancer progression by preventing YAP1 from beta-TrCP-mediated proteasomal degradation. | SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.
Liu J, Bai W, Zhou T, Xie Y, Yang B, Sun J, Wang Y, Li X, Hou X, Liu Z, Fu D, Yan J, Jiang W, Zhao K, Zhou B, Yuan S, Guo Y, Wang H, Chang A, Gao S, Shi L, Huang C, Yang S, Hao J. | 08/10/2023 |
| The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression. | The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression.
Lee KM, Seo EC, Lee JH, Kim HJ, Hwangbo C., Free PMC Article | 06/13/2023 |
| Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells. | Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells.
Kim O, Hwangbo C, Tran PT, Lee JH., Free PMC Article | 04/16/2022 |
| Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma. | Downregulation of SDCBP inhibits cell proliferation and induces apoptosis by regulating PI3K/AKT/mTOR pathway in gastric carcinoma.
Qian B, Yao Z, Yang Y, Li N, Wang Q. | 03/5/2022 |
| Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1beta. | Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β.
Pradhan AK, Maji S, Bhoopathi P, Talukdar S, Mannangatti P, Guo C, Wang XY, Cartagena LC, Idowu M, Landry JW, Sarkar D, Emdad L, Cavenee WK, Das SK, Fisher PB., Free PMC Article | 12/4/2021 |
| Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker. | Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker.
Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R., Free PMC Article | 08/28/2021 |
| Downregulation of exosomal miR1273a increases cisplatin resistance of nonsmall cell lung cancer by upregulating the expression of syndecan binding protein. | Downregulation of exosomal miR‑1273a increases cisplatin resistance of non‑small cell lung cancer by upregulating the expression of syndecan binding protein.
Zhao X, Li M, Dai X, Yang Y, Peng Y, Xu C, Dai N, Wang D., Free PMC Article | 07/24/2021 |
| Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity. | Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity.
Ma D, Liu S, Hu L, He Q, Shi W, Yan D, Cao Y, Zhang G, Wang Z, Wu J, Jiang C., Free PMC Article | 07/24/2021 |
| Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration. | Epstein-Barr Virus LMP1 Promotes Syntenin-1- and Hrs-Induced Extracellular Vesicle Formation for Its Own Secretion To Increase Cell Proliferation and Migration.
Nkosi D, Sun L, Duke LC, Patel N, Surapaneni SK, Singh M, Meckes DG Jr., Free PMC Article | 04/13/2021 |
| MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis. | MDA-9/Syntenin (SDCBP): Novel gene and therapeutic target for cancer metastasis.
Das SK, Maji S, Wechman SL, Bhoopathi P, Pradhan AK, Talukdar S, Sarkar D, Landry J, Guo C, Wang XY, Cavenee WK, Emdad L, Fisher PB., Free PMC Article | 04/3/2021 |
| Syntenin regulates melanogenesis via the p38 MAPK pathway. | Syntenin regulates melanogenesis via the p38 MAPK pathway.
Sun L, Guo C, Yan L, Li H, Sun J, Huo X, Xie X, Hu J., Free PMC Article | 03/27/2021 |
| Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor. | Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor.
Iwamoto K, Takahashi H, Okuzaki D, Osawa H, Ogino T, Miyoshi N, Uemura M, Matsuda C, Yamamoto H, Mizushima T, Mori M, Doki Y, Eguchi H., Free PMC Article | 03/20/2021 |
| Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. | Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles.
Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG Jr., Free PMC Article | 02/6/2021 |
| Syntenin overexpression in human lung cancer tissue and serum is associated with poor prognosis. | Syntenin overexpression in human lung cancer tissue and serum is associated with poor prognosis.
Luo P, Yang X, Huang S, Feng S, Ou Z., Free PMC Article | 10/24/2020 |
| Direct interactions between ALIX, syntenin and syndecan-4 are essential for proper enrichment of the ESCRT-III machinery at the cytokinetic abscission site. | The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis.
Addi C, Presle A, Frémont S, Cuvelier F, Rocancourt M, Milin F, Schmutz S, Chamot-Rooke J, Douché T, Duchateau M, Giai Gianetto Q, Salles A, Ménager H, Matondo M, Zimmermann P, Gupta-Rossi N, Echard A., Free PMC Article | 08/1/2020 |
| MiR-135b-5p was isolated as an essential biomarker to predict breast cancer (BC) metastasis at a very early stage. Our clinical patient cohort and functional data suggested that the inhibition of miR-135b-5p could promote metastasis by downregulating the direct target syndecan binding protein (SDCBP). | Repression of miR-135b-5p promotes metastasis of early-stage breast cancer by regulating downstream target SDCBP.
Pu T, Shen M, Li S, Yang L, Gao H, Xiao L, Zhong X, Zheng H, Liu Y, Ye F, Bu H. | 07/4/2020 |
| To help facilitate the investigation of syntenin-1 biology, developed were two specific monoclonal antibodies (Synt-2C6 and Synt-3A11) to spatially distinct linear sequence epitopes on syntenin-1, which were each designed to be unique at the six-amino acid level. In prostate tissue biopsies, Synt-3A11 defined atrophy and early-stage prostate cancer, whereas Synt-2C6 only showed minimal interaction with atrophic tissue. | A Paradigm in Immunochemistry, Revealed by Monoclonal Antibodies to Spatially Distinct Epitopes on Syntenin-1.
Johnson IRD, Sorvina A, Logan JM, Moore CR, Heatlie JK, Parkinson-Lawrence EJ, Selemidis S, O'Leary JJ, Butler LM, Brooks DA., Free PMC Article | 05/2/2020 |
| identify MDA-9 as a key contributor to NB pathogenesis and show that genetic or pharmacological inhibition suppresses NB pathogenesis by an integrin-mediated Src-disruption pathway | Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin.
Bhoopathi P, Pradhan AK, Bacolod MD, Emdad L, Sarkar D, Das SK, Fisher PB., Free PMC Article | 02/29/2020 |
| data confirm the key role of MDA-9/Syntenin in Human Liver Carcinoma biology. The presence of a regulation loop among MDA-9/Syntenin, NF-kappaB and RKIP provide new pharmacological approaches. | Potential Therapeutic Applications of MDA-9/Syntenin-NF-κB-RKIP Loop in Human Liver Carcinoma.
Notarbartolo M, Labbozzetta M, Pojero F, D'Alessandro N, Poma P. | 10/5/2019 |
| MDA-9/Syntenin physically interacted with insulin-like growth factor-1 receptor following treatment with insulin-like growth factor binding protein-2 (IGFBP2), regulating downstream signaling processes that enabled STAT3 phosphorylation. | The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion.
Das SK, Pradhan AK, Bhoopathi P, Talukdar S, Shen XN, Sarkar D, Emdad L, Fisher PB., Free PMC Article | 06/15/2019 |
| Syntenin1 exhibits a profound function in mediating T cells apoptosis by upregulating PD-L1 and thus could be used as a prognostic biomarker of TNBC. | Syntenin1/MDA-9 (SDCBP) induces immune evasion in triple-negative breast cancer by upregulating PD-L1.
Liu J, Yang Y, Wang H, Wang B, Zhao K, Jiang W, Bai W, Liu J, Yin J. | 03/9/2019 |
| Studied role of melanoma differentiation associated protein-9 (MDA-9)/Syntenin in autophagy of anoikis-resistant glioma stem cells. | MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.
Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB., Free PMC Article | 09/8/2018 |