| Abnormal open states patterns in the ATXN2 DNA sequence depends on the CAG repeats length. | Abnormal open states patterns in the ATXN2 DNA sequence depends on the CAG repeats length.
Drobotenko MI, Lyasota OM, Hernandez-Caceres JL, Labrada RR, Svidlov AA, Dorohova АA, Baryshev MG, Nechipurenko YD, Pérez LV, Dzhimak SS. | 10/3/2024 |
| Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules. | Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules.
Yamagishi R, Inagaki H, Suzuki J, Hosoda N, Sugiyama H, Tomita K, Hotta T, Hoshino SI., Free PMC Article | 08/28/2024 |
| Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort. | Clinical features, disease progression, and nuclear imaging in ATXN2-related parkinsonism in a longitudinal cohort.
Xu YD, Zhou XY, Wei SD, Liu FT, Zhao J, Tang YL, Shen B, Ding ZT, Wu JJ, Sun YM, Wang J. | 06/26/2024 |
| Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation. | Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation.
Petrauskas A, Fortunati DL, Kandi AR, Pothapragada SS, Agrawal K, Singh A, Huelsmeier J, Hillebrand J, Brown G, Chaturvedi D, Lee J, Lim C, Auburger G, VijayRaghavan K, Ramaswami M, Bakthavachalu B., Free PMC Article | 06/15/2024 |
| ATXN2 is a target of N-terminal proteolysis. | ATXN2 is a target of N-terminal proteolysis.
Chitre M, Emery P., Free PMC Article | 01/3/2024 |
| ATXN2-Mediated PI3K/AKT Activation Confers Gastric Cancer Chemoresistance and Attenuates CD8(+) T Cell Cytotoxicity. | ATXN2-Mediated PI3K/AKT Activation Confers Gastric Cancer Chemoresistance and Attenuates CD8(+) T Cell Cytotoxicity.
Wang Q, Cao T, Zhang X, Hui J, Wang C, Zhang W, Wang P, Zhou Y, Han S., Free PMC Article | 10/15/2022 |
| ATXN2 intermediate expansions in amyotrophic lateral sclerosis. | ATXN2 intermediate expansions in amyotrophic lateral sclerosis.
Glass JD, Dewan R, Ding J, Gibbs JR, Dalgard C, Keagle PJ, Shankaracharya, García-Redondo A, Traynor BJ, Chia R, Landers JE., Free PMC Article | 09/3/2022 |
| ATXN2-mediated translation of TNFR1 promotes esophageal squamous cell carcinoma via m(6)A-dependent manner. | ATXN2-mediated translation of TNFR1 promotes esophageal squamous cell carcinoma via m(6)A-dependent manner.
Li R, Zeng L, Zhao H, Deng J, Pan L, Zhang S, Wu G, Ye Y, Zhang J, Su J, Zheng Y, Deng S, Bai R, Zhuang L, Li M, Zuo Z, Lin D, Zheng J, Huang X., Free PMC Article | 07/30/2022 |
| VNTR (CAG)n polymorphism of the ATXN2 gene and metabolic parameters of cardiovascular risk associated with the degree of obesity in the Amerindian population of Oaxaca. | VNTR (CAG)n polymorphism of the ATXN2 gene and metabolic parameters of cardiovascular risk associated with the degree of obesity in the Amerindian population of Oaxaca.
Dávalos-Rodríguez NO, Rincón-Sánchez AR, Madrigal Ruiz PM, Flores-Alvarado LJ, López-Toledo S, Villafán-Bernal JR, Castro-Juárez CJ, Guzmán-López R, Siliceo-Murrieta JI, Ramirez-Garcia SA. | 03/5/2022 |
| Spinocerebellar ataxia type 2 from an evolutionary perspective: Systematic review and meta-analysis. | Spinocerebellar ataxia type 2 from an evolutionary perspective: Systematic review and meta-analysis.
Sena LS, Dos Santos Pinheiro J, Hasan A, Saraiva-Pereira ML, Jardim LB. | 01/29/2022 |
| LINC00941 promotes proliferation and metastasis of pancreatic adenocarcinoma by competitively binding miR-873-3p and thus upregulates ATXN2. | LINC00941 promotes proliferation and metastasis of pancreatic adenocarcinoma by competitively binding miR-873-3p and thus upregulates ATXN2.
Fang L, Wang SH, Cui YG, Huang L. | 01/8/2022 |
| Redox-mediated regulation of low complexity domain self-association. | Redox-mediated regulation of low complexity domain self-association.
Kato M, Tu BP, McKnight SL., Free PMC Article | 01/1/2022 |
| Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions. | Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions.
Watanabe R, Higashi S, Nonaka T, Kawakami I, Oshima K, Niizato K, Akiyama H, Yoshida M, Hasegawa M, Arai T., Free PMC Article | 11/13/2021 |
| DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery. | DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
Inagaki H, Hosoda N, Hoshino SI. | 07/10/2021 |
| Cortical network dysfunction revealed by magnetoencephalography in carriers of spinocerebellar ataxia 1 or 2 mutation. | Cortical network dysfunction revealed by magnetoencephalography in carriers of spinocerebellar ataxia 1 or 2 mutation.
Visani E, Mariotti C, Nanetti L, Mongelli A, Castaldo A, Panzica F, Rossi Sebastiano D, Nigri A, Grisoli M, Franceschetti S, Canafoglia L. | 05/15/2021 |
| Expanded CAG Repeats in ATXN1, ATXN2, ATXN3, and HTT in the 1000 Genomes Project. | Expanded CAG Repeats in ATXN1, ATXN2, ATXN3, and HTT in the 1000 Genomes Project.
Akçimen F, Ross JP, Liao C, Spiegelman D, Dion PA, Rouleau GA. | 05/8/2021 |
| A Novel Duplication in ATXN2 as Modifier for Spinocerebellar Ataxia 3 (SCA3) and C9ORF72-ALS. | A Novel Duplication in ATXN2 as Modifier for Spinocerebellar Ataxia 3 (SCA3) and C9ORF72-ALS.
Laffita-Mesa JM, Nennesmo I, Paucar M, Svenningsson P., Free PMC Article | 05/1/2021 |
| Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation. | Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylation.
Inagaki H, Hosoda N, Tsuiji H, Hoshino SI., Free PMC Article | 03/13/2021 |
| Redox-mediated regulation of an evolutionarily conserved cross-beta structure formed by the TDP43 low complexity domain. | Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain.
Lin Y, Zhou X, Kato M, Liu D, Ghaemmaghami S, Tu BP, McKnight SL., Free PMC Article | 01/16/2021 |
| Neuroimaging Biomarkers in SCA2 Gene Carriers. | Neuroimaging Biomarkers in SCA2 Gene Carriers.
Mascalchi M, Vella A., Free PMC Article | 11/21/2020 |
| The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression. | The RNA-Binding Protein ATXN2 is Expressed during Megakaryopoiesis and May Control Timing of Gene Expression.
Hansen M, Zeddies S, Meinders M, di Summa F, van Alphen FPJ, Hoogendijk AJ, Moore KS, Halbach M, Gutiérrez L, van den Biggelaar M, Thijssen-Timmer DC, Auburger GWJ, van den Akker E, von Lindern M, Rollmann E., Free PMC Article | 11/21/2020 |
| Patients with Parkinsonism feature had fewer CAG repeats in SCA2 compared to those with pure Ataxia presentation. The average age of symptom onset was significantly higher in the Parkinsonism group of SCA2 in a Taiwanese population. | Heterogeneous nonataxic phenotypes of spinocerebellar ataxia in a Taiwanese population.
Chen SJ, Lee NC, Chien YH, Hwu WL, Lin CH., Free PMC Article | 06/13/2020 |
| Ataxin-2 acts during stress responses, modulating mRNA translation and nutrient metabolism. | In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism.
Sen NE, Arsovic A, Meierhofer D, Brodesser S, Oberschmidt C, Canet-Pons J, Kaya ZE, Halbach MV, Gispert S, Sandhoff K, Auburger G., Free PMC Article | 04/25/2020 |
| Significantly greater levels of phosphorylated TDP-43 were identified in the motor cortex of cases with ALS with C9ORF72 expansions, and significantly greater amounts of phosphorylated TDP-43 were found in the spinal cord of cases with ALS with intermediate ATXN2 expansions. In contrast, however, similar levels of nonphosphorylated TDP-43 were found in motor cortex, spinal cord, and cerebellar vermis between ALS groups. | TDP-43 levels in the brain tissue of ALS cases with and without C9ORF72 or ATXN2 gene expansions.
Yang Y, Halliday GM, Kiernan MC, Tan RH. | 02/8/2020 |
| the weak association of the intermediate-length ATXN2 CAG repeat alleles with amyotrophic lateral sclerosis in the Japanese population may be explained by the fact that the distribution of normal CAG repeat alleles in the Japanese population is considerably different compared with those in other populations | Association of ATXN2 intermediate-length CAG repeats with amyotrophic lateral sclerosis correlates with the distributions of normal CAG repeat alleles among individual ethnic populations.
Naruse H, Matsukawa T, Ishiura H, Mitsui J, Takahashi Y, Takano H, Goto J, Toda T, Tsuji S. | 01/11/2020 |