| SALL2 methylation statistically correlated with a decrease in disease free survival in patients with oral squamous carcinoma. | SALL2 Is a Novel Prognostic Methylation Marker in Patients with Oral Squamous Carcinomas: Associations with SALL1 and SALL3 Methylation Status.
Imai A, Mochizuki D, Misawa Y, Nakagawa T, Endo S, Mima M, Yamada S, Kawasaki H, Kanazawa T, Misawa K. | 07/20/2019 |
| Sall2 may play a significant role in NIT-1 cell function. | Sall2 knockdown exacerbates palmitic acid induced dysfunction and apoptosis of pancreatic NIT-1 beta cells.
Wang Y, Liu J, Liu Z, Chen J, Hu X, Hu Y, Yuan Y, Wu G, Dai Z, Xu Y. | 10/13/2018 |
| Using RNA interference, the role of Spalt-like gene-2 (SALL2) was investigated in human ovarian carcinoma (OC) A2780 cells. Found downregulation of SALL2 promoted growth of the OC cell line. | Effect of siRNA-silencing of SALL2 gene on growth, migration and invasion of human ovarian carcinoma A2780 cells.
Miao F, Zhang X, Cao Y, Wang Y, Zhang X., Free PMC Article | 02/17/2018 |
| Understanding SALL2 function and the molecular mechanisms governing its expression and activity is critical to comprehend why and how SALL2 could contribute to disease. This knowledge will open new perspectives for the development of molecular targeted approaches in disease | Developmental SALL2 transcription factor: a new player in cancer.
Hermosilla VE, Hepp MI, Escobar D, Farkas C, Riffo EN, Castro AF, Pincheira R. | 10/7/2017 |
| Sall2 enhanced the p16 minigene blocking of cell cycle progression and p16 knockdown with siRNA abolished most of the Sall2 inhibition of cell cycle progression | Sal-like protein 2 upregulates p16 expression through a proximal promoter element.
Wu Z, Cheng K, Shi L, Li Z, Negi H, Gao G, Kamle S, Li D., Free PMC Article | 06/20/2015 |
| Mechanisms of silencing SALL2 in OVCA cell lines and primary tumors and possible therapeutic approaches for ovarian carcinoma are discussed in this review. | The tumor suppressor protein p150(Sal2) in carcinogenesis.
Sung CK, Yim H. | 06/20/2015 |
| A role for SALL2 in eye morphogenesis and loss of function of the gene causes ocular coloboma in humans and mice. | Mutation of SALL2 causes recessive ocular coloboma in humans and mice.
Kelberman D, Islam L, Lakowski J, Bacchelli C, Chanudet E, Lescai F, Patel A, Stupka E, Buck A, Wolf S, Beales PL, Jacques TS, Bitner-Glindzicz M, Liasis A, Lehmann OJ, Kohlhase J, Nischal KK, Sowden JC., Free PMC Article | 12/6/2014 |
| The SALL2 P2 promoter is hypermethylated in a majority of serous ovarian carcinomas. | Promoter methylation of the SALL2 tumor suppressor gene in ovarian cancers.
Sung CK, Li D, Andrews E, Drapkin R, Benjamin T., Free PMC Article | 12/28/2013 |
| c-MYC may come under negative regulation by p150, consistent with the action of p150 as a putative tumor suppressor. | The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.
Sung CK, Yim H, Gu H, Li D, Andrews E, Duraisamy S, Li C, Drapkin R, Benjamin T., Free PMC Article | 02/23/2013 |
| Here, the authors report that human papillomavirus type 16 E6 targets the cellular factor p150(Sal2), which positively regulates p21(WAF1) transcription. | Human papillomavirus type 16 E6 inhibits p21(WAF1) transcription independently of p53 by inactivating p150(Sal2).
Parroche P, Touka M, Mansour M, Bouvard V, Thépot A, Accardi R, Carreira C, Roblot GG, Sylla BS, Hasan U, Tommasino M. | 10/22/2011 |
| Results demonstrate binding of p150(Sal2) to two natural promoters with GC elements related to the optimal binding sequence defined in vitro and whose regulation is important for suppression of tumor growth. | DNA-binding and regulatory properties of the transcription factor and putative tumor suppressor p150(Sal2).
Gu H, Li D, Sung CK, Yim H, Troke P, Benjamin T., Free PMC Article | 08/20/2011 |
| A CUL4/DDB1 E3 ligase containing RBBP7 as the p150(Sal2) receptor has been identified as mediating the destruction of p150(Sal2) as cells transition from a quiescent to an actively growing state. | Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).
Sung CK, Dahl J, Yim H, Rodig S, Benjamin TL., Free PMC Article | 06/4/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC., Free PMC Article | 09/15/2010 |
| Studies indicate that vertebrate sal orthologues (spalt-like/sall) have important developmental roles during neural development and organogenesis and gentic diseases. | Regulation and function of Spalt proteins during animal development.
de Celis JF, Barrio R. | 03/22/2010 |
| These data establish Sall2 as a link between p75 neurotrophin receptor and transcriptional events that regulate the growth and development of neuronal cells. | Sall2 is a novel p75NTR-interacting protein that links NGF signalling to cell cycle progression and neurite outgrowth.
Pincheira R, Baerwald M, Dunbar JD, Donner DB., Free PMC Article | 01/21/2010 |
| Epidermal growth factor receptor (a potential therapeutic target) and SALL2 stained most cases of synovial sarcoma; staining was significantly less common among other tested sarcomas. | Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.
Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M., Free PMC Article | 01/21/2010 |
| Results suggest that p150(Sal2), acting in part as a p53-independent regulator of p21 and BAX, can function in some cell types as a regulator of cell growth and survival [p150(Sal2)] | p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP).
Li D, Tian Y, Ma Y, Benjamin T., Free PMC Article | 01/21/2010 |