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    S100A13 S100 calcium binding protein A13 [ Homo sapiens (human) ]

    Gene ID: 6284, updated on 7-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (>/= 30 years) type 2 diabetes without diabetic retinopathy.

    Genome-wide analysis of DNA methylation identifies S100A13 as an epigenetic biomarker in individuals with chronic (≥ 30 years) type 2 diabetes without diabetic retinopathy.
    Li T, Xu Y, Shi Y, Chen J, Lin S, Zhu J, Xu X, Lu L, Zou H., Free PMC Article

    08/21/2021
    An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.

    An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.
    Al-Mutairy EA, Imtiaz FA, Khalid M, Al Qattan S, Saleh S, Mahmoud LM, Al-Saif MM, Al-Haj L, Al-Enazi A, AlJebreen AM, Mohammed SF, Mobeireek AF, Alkattan K, Chisti MA, Luzina IG, Al-Owain M, Weheba I, Abdelsayed AM, Ramzan K, Janssen LJ, Conca W, Alaiya A, Collison KS, Meyer BF, Atamas SP, Khabar KS, Hasday JD, Al-Mohanna F., Free PMC Article

    09/19/2020
    These findings unveil a critical role of the non-classical secretory pathway of IL-1alpha in cellular senescence and SASP regulation.

    S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
    Su Y, Xu C, Sun Z, Liang Y, Li G, Tong T, Chen J., Free PMC Article

    04/4/2020
    High S100A13 expression is closely associated with high intratumoral angiogenesis and poor prognosis in patients with stage I NSCLC. Immunohistochemical evaluation of S100A13 expression, along with an examination of the perioperative extent of angiolymphatic invasion, has value for predicting prognosis.

    Overexpression of S100A13 protein is associated with tumor angiogenesis and poor survival in patients with early-stage non-small cell lung cancer.
    Miao S, Qiu T, Zhao Y, Wang H, Sun X, Wang Y, Xuan Y, Qin Y, Jiao W., Free PMC Article

    04/13/2019
    This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion.

    The association between S100A13 and HMGA1 in the modulation of thyroid cancer proliferation and invasion.
    Zhong J, Liu C, Chen YJ, Zhang QH, Yang J, Kang X, Chen SR, Wen GB, Zu XY, Cao RX., Free PMC Article

    11/12/2016
    S100A13 interacts with the C2 domain of RAGE.

    Interaction of S100A13 with C2 domain of receptor for advanced glycation end products (RAGE).
    Rani SG, Sepuru KM, Yu C.

    09/13/2014
    S100A13 is involved in cutaneous malignant melanoma resistance to DTIC/TMZ.

    Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance.
    Azimi A, Pernemalm M, Frostvik Stolt M, Hansson J, Lehtiö J, Egyházi Brage S, Hertzman Johansson C., Free PMC Article

    07/19/2014
    the IL1alpha-S100A13 tetrameric complex is the key complex formed during the non-classical pathway of IL1alpha release

    The IL1alpha-S100A13 heterotetrameric complex structure: a component in the non-classical pathway for interleukin 1alpha secretion.
    Mohan SK, Yu C., Free PMC Article

    07/2/2011
    S100A13 promotes the release of FGF-1 protein, but does not affect the transportation of FGF-1 protein in human umbilical vein endothelial cells.

    Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells.
    Cao R, Yan B, Yang H, Zu X, Wen G, Zhong J.

    11/6/2010
    S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth.

    S100A13 is a new angiogenic marker in human melanoma.
    Massi D, Landriscina M, Piscazzi A, Cosci E, Kirov A, Paglierani M, Di Serio C, Mourmouras V, Fumagalli S, Biagioli M, Prudovsky I, Miracco C, Santucci M, Marchionni N, Tarantini F., Free PMC Article

    09/6/2010
    Despite the high similarity of the backbone conformation in each protomer, the crystal structures of human S100A13 at pH 7.5 and at pH 6.0 exhibit recognizable differences in the relative orientation of the protomers within the dimer

    Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution.
    Imai FL, Nagata K, Yonezawa N, Nakano M, Tanokura M., Free PMC Article

    01/21/2010
    detected in both cells and fibers of the hippocampus at 12 weeks gestation, slightly stronger at 20 weeks, and then decreased with age. In the temporal cortex, strong in all cellular layers at 12 to 24 weeks, declined with age from 28 weeks onwards.

    Differential expression of S100 proteins in the developing human hippocampus and temporal cortex.
    Chan WY, Xia CL, Dong DC, Heizmann CW, Yew DT.

    01/21/2010
    Stress-induced export of IL-1alpha involves the intracellular association with the Cu2+-binding protein, S100A13; the expression of a S100A13 mutant functions as a dominant-negative repressor of IL-1alpha release.

    S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells.
    Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T.

    01/21/2010
    data show that the expression of endoglin and S100A13 protein corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis

    Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis.
    Hayrabedyan S, Kyurkchiev S, Kehayov I.

    01/21/2010
    Human S100A13 was heterologously expressed in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method.

    Crystallization and preliminary X-ray analysis of human S100A13.
    Imai FL, Nagata K, Yonezawa N, Yu J, Ito E, Kanai S, Tanokura M, Nakano M., Free PMC Article

    01/21/2010
    In human astrocytic gliomas, S100A13 was significantly up-regulated in high-grade vascularized gliomas. Moreover, S100A13 expression significantly correlated with microvessel density and tumour grading.

    S100A13, a new marker of angiogenesis in human astrocytic gliomas.
    Landriscina M, Schinzari G, Di Leonardo G, Quirino M, Cassano A, D'Argento E, Lauriola L, Scerrati M, Prudovsky I, Barone C.

    01/21/2010
    S100A13 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells

    S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells.
    Hsieh HL, Schäfer BW, Weigle B, Heizmann CW.

    01/21/2010
    S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. S100A13 has the unique structural feature with all alpha-helices being amphiphilic.

    Crystal structure study on human S100A13 at 2.0 A resolution.
    Li M, Zhang PF, Pan XW, Chang WR.

    01/21/2010
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