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    S100A6 S100 calcium binding protein A6 [ Homo sapiens (human) ]

    Gene ID: 6277, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC Revealed by Single Cell RNA-seq.

    Involvement of S100A6/S100A11 in T-Cell Immune Regulatory in HCC Revealed by Single Cell RNA-seq.
    Zhou R, Pei B, Li X, Zhang X., Free PMC Article

    07/22/2024
    S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/beta-catenin signaling pathway: an in vitro and in vivo study.

    S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
    Yang F, Duan Y, Li Y, Zhu D, Wang Z, Luo Z, Zhang Y, Zhang G, He X, Kang X., Free PMC Article

    06/28/2024
    S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.

    S100A6 drives lymphatic metastasis of liver cancer via activation of the RAGE/NF-kB/VEGF-D pathway.
    Chen T, Ruan Y, Ji L, Cai J, Tong M, Xue Y, Zhao H, Cai X, Xu J.

    03/26/2024
    Interaction of S100A6 Protein with the Four-Helical Cytokines.

    Interaction of S100A6 Protein with the Four-Helical Cytokines.
    Kazakov AS, Deryusheva EI, Rastrygina VA, Sokolov AS, Permyakova ME, Litus EA, Uversky VN, Permyakov EA, Permyakov SE., Free PMC Article

    10/5/2023
    The S100 calcium-binding protein A6 plays a crucial role in hepatic steatosis by mediating lipophagy.

    The S100 calcium-binding protein A6 plays a crucial role in hepatic steatosis by mediating lipophagy.
    Du Q, Zhu T, Wen G, Jin H, An J, Xu J, Xie R, Zhu J, Yang X, Zhang T, Liu Q, Yao S, Yang X, Tuo B, Ma X., Free PMC Article

    09/20/2023
    The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential.

    The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential.
    Yang F, Ma J, Zhu D, Wang Z, Li Y, He X, Zhang G, Kang X., Free PMC Article

    08/9/2023
    S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy.

    S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy.
    Qi M, Yi X, Yue B, Huang M, Zhou S, Xiong J., Free PMC Article

    05/31/2023
    S100A6 participates in initiation of autoimmune encephalitis and is under epigenetic control.

    S100A6 participates in initiation of autoimmune encephalitis and is under epigenetic control.
    Lin CH, Li SC, Lin MH, Ho CJ, Lu YT, Lin Y, Lin PH, Tsai KW, Tsai MH., Free PMC Article

    03/20/2023
    S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.

    S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
    Chen B, Zheng D, Liu C, Bhandari A, Hirachan S, Shen C, Mainali S, Li H, Jiang W, Xu J, Zhang X, Tang K, Zhang W.

    02/22/2023
    S100A6 Protein-Expression and Function in Norm and Pathology.

    S100A6 Protein-Expression and Function in Norm and Pathology.
    Leśniak W, Filipek A., Free PMC Article

    01/28/2023
    S100A6 as a Constituent and Potential Marker of Adult and Cancer Stem Cells.

    S100A6 as a Constituent and Potential Marker of Adult and Cancer Stem Cells.
    Leśniak W, Filipek A.

    11/5/2022
    SNHG1 functions as an oncogenic lncRNA and promotes osteosarcoma progression by up-regulating S100A6 via miR-493-5p.

    SNHG1 functions as an oncogenic lncRNA and promotes osteosarcoma progression by up-regulating S100A6 via miR-493-5p.
    Liu Q, Luo J, Wang H, Zhang L, Jin G., Free PMC Article

    04/2/2022
    Identification and Biochemical Characterization of High Mobility Group Protein 20A as a Novel Ca(2+)/S100A6 Target.

    Identification and Biochemical Characterization of High Mobility Group Protein 20A as a Novel Ca(2+)/S100A6 Target.
    Yamamoto M, Kondo R, Hozumi H, Doi S, Denda M, Magari M, Kanayama N, Hatano N, Morishita R, Tokumitsu H., Free PMC Article

    10/2/2021
    S100A6 represses Calu-6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis.

    S100A6 represses Calu-6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis.
    Wang T, Han S, Du G., Free PMC Article

    09/18/2021
    Were Ancestral Proteins Less Specific?

    Were Ancestral Proteins Less Specific?
    Wheeler LC, Harms MJ., Free PMC Article

    08/14/2021
    Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study.

    Serum S100A6, S100A8, S100A9 and S100A11 proteins in colorectal neoplasia: results of a single centre prospective study.
    Moravkova P, Kohoutova D, Vavrova J, Bures J.

    07/17/2021
    S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis.

    S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis.
    Dong XH, Dai D, Yang ZD, Yu XO, Li H, Kang H., Free PMC Article

    05/29/2021
    S100A6 and Its Brain Ligands in Neurodegenerative Disorders.

    S100A6 and Its Brain Ligands in Neurodegenerative Disorders.
    Filipek A, Leśniak W., Free PMC Article

    04/3/2021
    Blocking the interface region amongst S100A6 and RAGE V domain via S100B protein.

    Blocking the interface region amongst S100A6 and RAGE V domain via S100B protein.
    Sung HY, Dowarha D, Chou RH, Yu C.

    03/20/2021
    HaCaT keratinocytes overexpressing S100A6 had enhanced EGFR, phospho EGFR, and phospho extracellular signal-regulated kinase 1/2 (pERK1/2) staining intensity and level coupled to higher signal transducer and activator of transcription 3 (STAT3) activity.

    S100A6 activates EGFR and its downstream signaling in HaCaT keratinocytes.
    Graczyk-Jarzynka A, Sobiak B, Mlącki M, Wilanowski T, Leśniak W.

    06/13/2020
    Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia

    Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.
    Güzel C, van den Berg CB, Duvekot JJ, Stingl C, van den Bosch TPP, van der Weiden M, Steegers EAP, Steegers-Theunissen RPM, Luider TM., Free PMC Article

    02/1/2020
    lysozyme, most probably by blocking the interaction between S100A6 and RAGE, inhibits cell proliferation while tranilast may reverse this effect by binding to lysozyme. In conclusion, studies presented in this work, describing the protein-protein/-drug interactions, are of great importance for designing new therapies to treat diseases associated with cell proliferation such as cancers.

    Lysozyme as the anti-proliferative agent to block the interaction between S100A6 and the RAGE V domain.
    Khan MI, Dowarha D, Katte R, Chou RH, Filipek A, Yu C., Free PMC Article

    01/18/2020
    REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1

    Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.
    Filipek A, Leśniak W.

    06/29/2019
    The expression MMP-9 and S100A6 in the tear film decreased in keratoconus patients after corneal collagen crosslinking.

    Changes in tear biomarker levels in keratoconus after corneal collagen crosslinking.
    Recalde JI, Duran JA, Rodriguez-Agirretxe I, Soria J, Sanchez-Tena MA, Pereiro X, Suarez T, Acera A., Free PMC Article

    06/15/2019
    Report alterations in the expression of cannabinoid receptors, apelin and S100A6 in the hearts of women over 50.

    Comparative evaluation of cannabinoid receptors, apelin and S100A6 protein in the heart of women of different age groups.
    Kasacka I, Piotrowska Ż, Filipek A, Lebkowski W., Free PMC Article

    06/1/2019
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