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    S100A3 S100 calcium binding protein A3 [ Homo sapiens (human) ]

    Gene ID: 6274, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.

    An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.
    Al-Mutairy EA, Imtiaz FA, Khalid M, Al Qattan S, Saleh S, Mahmoud LM, Al-Saif MM, Al-Haj L, Al-Enazi A, AlJebreen AM, Mohammed SF, Mobeireek AF, Alkattan K, Chisti MA, Luzina IG, Al-Owain M, Weheba I, Abdelsayed AM, Ramzan K, Janssen LJ, Conca W, Alaiya A, Collison KS, Meyer BF, Atamas SP, Khabar KS, Hasday JD, Al-Mohanna F., Free PMC Article

    09/19/2020
    This review discusses the role and potential use as biomarkers of semaphorin 3A (SEMA3A), protocadherin 9 (PCDH9), and S100 calcium binding protein A3 (S100A3) in carcinogenesis and chemoresistance of various tumors, including ovarian cancer.

    Semaphorin 3A (SEMA3A), protocadherin 9 (PCdh9), and S100 calcium binding protein A3 (S100A3) as potential biomarkers of carcinogenesis and chemoresistance of different neoplasms, including ovarian cancer - review of literature.
    Izycka N, Sterzynska K, Januchowski R, Nowak-Markwitz E.

    02/15/2020
    Opposite effects on RARalpha/PML-RARalpha levels and ATRA-induced differentiation are observed upon S100A3 overexpression.

    S100A3 a partner protein regulating the stability/activity of RARα and PML-RARα in cellular models of breast/lung cancer and acute myeloid leukemia.
    Gianni M, Terao M, Kurosaki M, Paroni G, Brunelli L, Pastorelli R, Zanetti A, Lupi M, Acquavita A, Bolis M, Fratelli M, Rochette-Egly C, Garattini E., Free PMC Article

    05/4/2019
    S100A3 expression is significantly upregulated in human masticatory mucosa during wound healing

    Human gingiva transcriptome during wound healing.
    Wang Y, Tatakis DN.

    03/22/2017
    One disulfide bridge is between Cys30 in the N-terminal pseudo-EF-hand and Cys68 in the C-terminal EF-hand (SS1), and another disulfide bridge attaches Cys99 in the C-terminal coil structure to Cys81 in helix IV (SS2).

    Refined crystal structures of human Ca(2+)/Zn(2+)-binding S100A3 protein characterized by two disulfide bridges.
    Unno M, Kawasaki T, Takahara H, Heizmann CW, Kizawa K.

    06/18/2011
    Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)

    Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
    Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S.

    04/7/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.
    Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S.

    09/16/2009
    cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3)

    Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle.
    Kizawa K, Takahara H, Troxler H, Kleinert P, Mochida U, Heizmann CW.

    01/21/2010
    structure was solved by MIRAS phasing

    Metal-free MIRAS phasing: structure of apo-S100A3.
    Mittl PR, Fritz G, Sargent DF, Richmond TJ, Heizmann CW, Grütter MG.

    01/21/2010
    Purification and characterization of the S100A3 protein from human hair cuticles.

    Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles.
    Kizawa K, Troxler H, Kleinert P, Inoue T, Toyoda M, Morohashi M, Heizmann CW.

    01/21/2010
    crystal structure of S100A3 at 1.7-A resolution

    The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution.
    Fritz G, Mittl PR, Vasak M, Grutter MG, Heizmann CW.

    01/21/2010
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