| Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer. | Friend or Foe: Regulation, Downstream Effectors of RRAD in Cancer.
Sun Z, Li Y, Tan X, Liu W, He X, Pan D, Li E, Xu L, Long L., Free PMC Article | 04/5/2023 |
| Reconstitution of beta-adrenergic regulation of CaV1.2: Rad-dependent and Rad-independent protein kinase A mechanisms. | Reconstitution of β-adrenergic regulation of Ca(V)1.2: Rad-dependent and Rad-independent protein kinase A mechanisms.
Katz M, Subramaniam S, Chomsky-Hecht O, Tsemakhovich V, Flockerzi V, Klussmann E, Hirsch JA, Weiss S, Dascal N., Free PMC Article | 12/4/2021 |
| RRAD expression in gastric and colorectal cancer with peritoneal carcinomatosis. | RRAD expression in gastric and colorectal cancer with peritoneal carcinomatosis.
Kim HK, Lee I, Kim ST, Lee J, Kim KM, Park JO, Kang WK., Free PMC Article | 11/21/2020 |
| RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome. | RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome.
Belbachir N, Portero V, Al Sayed ZR, Gourraud JB, Dilasser F, Jesel L, Guo H, Wu H, Gaborit N, Guilluy C, Girardeau A, Bonnaud S, Simonet F, Karakachoff M, Pattier S, Scott C, Burel S, Marionneau C, Chariau C, Gaignerie A, David L, Genin E, Deleuze JF, Dina C, Sauzeau V, Loirand G, Baró I, Schott JJ, Probst V, Wu JC, Redon R, Charpentier F, Le Scouarnec S., Free PMC Article | 10/10/2020 |
| this study established RRAD to be a biomarker as well as a novel negative regulator of cellular senescence. | Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence.
Wei Z, Guo H, Qin J, Lu S, Liu Q, Zhang X, Zou Y, Gong Y, Shao C. | 12/14/2019 |
| our study revealed that RRAD expression was decreased in Hepatocellular carcinoma (HCC) tumor tissues and predicted poor clinical outcome for HCC patients and played an important role in regulating aerobic glycolysis and cell invasion and metastasis and may represent potential targets for improving the treatment of HCC | RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Shang R, Wang J, Sun W, Dai B, Ruan B, Zhang Z, Yang X, Gao Y, Qu S, Lv X, Tao K, Wang L, Dou K, Wang D. | 02/18/2017 |
| Data show that Ras-related associated with diabetes protein (RRAD) directly binds to the p65 subunit of the NF-kappa B (NF-kappaB)complex and inhibits the nuclear translocation of p65, which in turn negatively regulates the NF-kappaB signaling | RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling.
Liu J, Zhang C, Wu R, Lin M, Liang Y, Liu J, Wang X, Yang B, Feng Z., Free PMC Article | 04/30/2016 |
| Brg1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating RRAD in aortic dissection. | Brahma-related gene 1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating Ras-related associated with diabetes in the pathophysiologic processes of aortic dissection.
Liao WL, Tan MW, Yuan Y, Wang GK, Wang C, Tang H, Xu ZY. | 04/2/2016 |
| RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. | RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.
Yeom SY, Nam DH, Park C. | 08/15/2015 |
| RRAD expression is frequently decreased in lung cancer. Ectopic expression of RRAD greatly reduces glycolysis whereas knockdown of RRAD promotes glycolysis in lung cancer cells. | Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD.
Zhang C, Liu J, Wu R, Liang Y, Lin M, Liu J, Chan CS, Hu W, Feng Z., Free PMC Article | 06/6/2015 |
| Rad suppresses the NF-Kappa-B mediated transcription and downstream gene activation. Rad can directly bind to RelA/p65 and suppress the interaction of RelA/p65 with the NF-kappa-B response DNA element. | Rad GTPase inhibits the NFκB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Hsiao BY, Chang TK, Wu IT, Chen MY. | 01/17/2015 |
| Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer | Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.
Wang Y, Li G, Mao F, Li X, Liu Q, Chen L, Lv L, Wang X, Wu J, Dai W, Wang G, Zhao E, Tang KF, Sun ZS., Free PMC Article | 12/20/2014 |
| RRAD hypermethylation is associated with esophageal squamous cell carcinoma. | Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.
Jin Z, Feng X, Jian Q, Cheng Y, Gao Y, Zhang X, Wang L, Zhang Y, Huang W, Fan X, Chen S, Yu H, Zhao Z, Dong M, Liu J, Mori Y, Meltzer SJ. | 01/11/2014 |
| Mouse Rad Q65P (the murine equivalent of human Rad Q66P) inhibits L-type currents conducted by CaV1.2 or CaV1.3 channels as potently as wild-type Rad (>95% inhibition of both channels). | Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.
Meza U, Beqollari D, Romberg CF, Papadopoulos S, Bannister RA. | 11/30/2013 |
| Rad over expression could be a molecular target to improve bortezomib sensitivity in human leukemia and lymphoma. | Rad knockdown induces mitochondrial apoptosis in bortezomib resistant leukemia and lymphoma cells.
Yeom SY, Lee SJ, Kim WS, Park C. | 10/13/2012 |
| results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development | Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
Mo Y, Midorikawa K, Zhang Z, Zhou X, Ma N, Huang G, Hiraku Y, Oikawa S, Murata M. | 09/8/2012 |
| the implication of oxidative stress in modulating Rad expression, in association with the initiation and progression of amyotrophic lateral sclerosis muscle atrophy | Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis.
Halter B, Gonzalez de Aguilar JL, Rene F, Petri S, Fricker B, Echaniz-Laguna A, Dupuis L, Larmet Y, Loeffler JP. | 09/13/2010 |
| It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. | A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment.
Lee I, Yeom SY, Lee SJ, Kang WK, Park C. | 06/28/2010 |
| Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway | Rad GTPase deficiency leads to cardiac hypertrophy.
Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE., Free PMC Article | 01/21/2010 |
| occurrence of an unusual TG 3' splice site in intron 1 | Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M., Free PMC Article | 10/9/2007 |
| Methylation and gene silencing of the Ras-related GTPase gene is associated with lung and breast cancers | Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
Suzuki M, Shigematsu H, Shames DS, Sunaga N, Takahashi T, Shivapurkar N, Iizasa T, Minna JD, Fujisawa T, Gazdar AF. | 01/21/2010 |
| crystallization and preliminary crystallographic analysis of human Rad GTPase | Expression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPase.
Yanuar A, Sakurai S, Kitano K, Hakoshima T., Free PMC Article | 01/21/2010 |
| Crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. | Crystal structure of human Rad GTPase of the RGK-family.
Yanuar A, Sakurai S, Kitano K, Hakoshima T. | 01/21/2010 |
| Evidence from Rad transgenic mice suggests that the Rad-associated signaling pathway may play a role in arrhythmogenesis in diverse cardiac diseases. | Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.
Yada H, Murata M, Shimoda K, Yuasa S, Kawaguchi H, Ieda M, Adachi T, Murata M, Ogawa S, Fukuda K. | 01/21/2010 |