| Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease. | Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease.
Wang H, Sun W, Li F, Jiang P, Wang L, Zhou N, Feng L., Free PMC Article | 01/30/2024 |
| Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons. | Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.
Yi J, Bertels Z, Del Rosario JS, Widman AJ, Slivicki RA, Payne M, Susser HM, Copits BA, Gereau RW 4th., Free PMC Article | 12/22/2023 |
| The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency. | The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.
Dyga W, Obtulowicz A, Mikolajczyk T, Bogdali A, Dubiela P, Obtulowicz K., Free PMC Article | 10/8/2022 |
| Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma. | Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.
Bertolini F, Carriero V, Bullone M, Sprio AE, Defilippi I, Sorbello V, Gani F, Di Stefano A, Ricciardolo FLM. | 07/17/2021 |
| Kinin B1 receptor: A target for neuroinflammation in hypertension. | Kinin B1 receptor: A target for neuroinflammation in hypertension.
Sriramula S. | 04/3/2021 |
| The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy. | The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy.
Brondani LA, Crispim D, Pisco J, Guimarães JA, Berger M. | 10/24/2020 |
| Our work shows for the first time that the interaction between CPM and kinin B1 receptor alters not only B1R pharmacology, but also modulates enzyme expression and activity. | Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.
Guimarães PB, da Silva RF, Hoff CC, Fernandes L, Nakaie CR, Chagas JR, Carmona AK, Bader M, Pesquero JB. | 02/1/2020 |
| the putative mechanisms underlying the anticancer activities of cell-penetrant B1R antagonists were assessed by analyzing cell cycle regulation and signaling molecules related to cell survival and apoptosis | Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.
Dubuc C, Savard M, Bovenzi V, Lessard A, Côté J, Neugebauer W, Geha S, Chemtob S, Gobeil F Jr. | 01/25/2020 |
| There is a divergence in BKR1 gene expression in subcutaneous white adipose tissue between patients with and without coronary artery disease and is associated with metabolic parameters. | Bradykinin receptors gene expression in white adipose tissue in nondiabetic patients with coronary artery disease.
Marketou ME, Kochiadakis G, Kontaraki J, Zacharis E, Kanoupakis E, Kallergis E, Mavrakis H, Tsiverdis P, Lempidakis D, Konstantinou J, Fragkiadakis K, Chlouverakis G, Vardas P, Parthenakis F. | 06/23/2019 |
| Results indicate that interaction of phosphorylated-STAT3 and acetylated-SP-1 modulates IL-8 expression-mediated glioblastoma migration. The present study also indicates that B1R and the phosphorylated-STAT3/acetylated-SP-1 signaling pathways could serve as therapeutic targets for developing a novel glioblastoma therapy. | Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1.
Liu YS, Hsu JW, Lin HY, Lai SW, Huang BR, Tsai CF, Lu DY. | 03/9/2019 |
| High BKB1R expression is associated with lung inflammation and injury. | Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.
Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr, Chappell M, Hackam DJ, Jia H., Free PMC Article | 01/12/2019 |
| BK receptors, B1 and B2 (BKR-B1 and B2), were also detected in both epithelial and stromal cells of endometriotic lesions. The localization of BKR-B1 was nucleus mainly, whereas BKR-B2 was detected at cytoplasm. | Bradykinin system is involved in endometriosis-related pain through endothelin-1 production.
Yoshino O, Yamada-Nomoto K, Kobayashi M, Andoh T, Hongo M, Ono Y, Hasegawa-Idemitsu A, Sakai A, Osuga Y, Saito S. | 01/12/2019 |
| The findings revealed that serum B1R levels may provide prognostic information and currently act as potential indicators for progression in atherosclerosis. | Kinin B1 receptor as a novel, prognostic progression biomarker for carotid atherosclerotic plaques.
Liu T, Liu H, Feng L, Xiao B., Free PMC Article | 06/30/2018 |
| Data show that mRNA and protein of bradykinin type 2 receptors, but not bradykinin type 1 receptors, were abundant in cultured c-Kit+ progenitor cells. | Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells.
Li G, Wang Y, Li GR., Free PMC Article | 07/8/2017 |
| promotes adhesion of neutrophils to endothelial cells | Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1.
Figueroa CD, Matus CE, Pavicic F, Sarmiento J, Hidalgo MA, Burgos RA, Gonzalez CB, Bhoola KD, Ehrenfeld P. | 12/19/2015 |
| kB1R heterodimerizes with kB2Rs in co-transfected HEK293 cells and natively expressing endothelial cells, resulting in significant internalization and desensitization of the kB1R response in cells pre-treated with kB2R agonist. | Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.
Zhang X, Brovkovych V, Zhang Y, Tan F, Skidgel RA., Free PMC Article | 08/15/2015 |
| BKR1 and BKR2 gene expression on peripheral monocytes is upregulated in essential hypertension | Differential gene expression of bradykinin receptors 1 and 2 in peripheral monocytes from patients with essential hypertension.
Marketou ME, Kontaraki J, Zacharis E, Parthenakis F, Maragkoudakis S, Gavras I, Gavras H, Vardas PE. | 08/15/2015 |
| B1 receptor-mediated vasodilatation in myometrial vessels absent in pre-eclampsia | Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia.
Moyes AJ, Gray GA, Denison FC. | 04/18/2015 |
| B1R agonist acts as a functional stimulus for the secretion of KLK1 and KLK6, an event relevant for kinin production and cell invasion, respectively | Bioregulation of kallikrein-related peptidases 6, 10 and 11 by the kinin B₁ receptor in breast cancer cells.
Ehrenfeld P, Manso L, Pavicic MF, Matus CE, Borquez C, Lizama A, Sarmiento J, Poblete MT, Bhoola KD, Naran A, Figueroa CD. | 03/28/2015 |
| Bradykinin B1 receptor signaling depends on receptor endocytosis. | Kinin-stimulated B1 receptor signaling depends on receptor endocytosis whereas B2 receptor signaling does not.
Enquist J, Sandén C, Skröder C, Mathis SA, Leeb-Lundberg LM. | 01/31/2015 |
| APJ and B1R can form heterodimers in transfected HEK293 cells and activations of APJ and B1R could up-regulate eNOS phosphorylation | Heterodimerization of human apelin and bradykinin 1 receptors: novel signal transduction characteristics.
Bai B, Liu L, Zhang N, Wang C, Jiang Y, Chen J. | 01/17/2015 |
| investigated if expression of B1 and B2 kinin receptors can be affected by IL-4 and IL-13; data show, for the first time, that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism | IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.
Souza PP, Brechter AB, Reis RI, Costa CA, Lundberg P, Lerner UH., Free PMC Article | 10/11/2014 |
| A novel B1R splice variant and promoter regulatory elements determine tissue-specific B1R expression. | Novel kinin B₁ receptor splice variant and 5'UTR regulatory elements are responsible for cell specific B₁ receptor expression.
Cheah FY, Baltic S, Temple SE, Bhoola K, Thompson PJ., Free PMC Article | 10/4/2014 |
| the relevance of kinin B1 and B2 receptors in bladder cancer, was investigated. | Functional and molecular characterization of kinin B1 and B 2 receptors in human bladder cancer: implication of the PI3Kγ pathway.
Sgnaolin V, Pereira TC, Bogo MR, Zanin R, Battastini AM, Morrone FB, Campos MM. | 02/15/2014 |
| CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. | Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.
Zhang X, Tan F, Skidgel RA., Free PMC Article | 01/25/2014 |