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    RPS14 ribosomal protein S14 [ Homo sapiens (human) ]

    Gene ID: 6208, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.

    Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.
    Han L, Huo Y, Huang L, Zheng Y, Yu X, Zhang N, Yang M.

    02/20/2024
    RPS14 promotes the development and progression of glioma via p53 signaling pathway.

    RPS14 promotes the development and progression of glioma via p53 signaling pathway.
    Hu S, Cai J, Fang H, Chen Z, Zhang J, Cai R.

    01/28/2023
    Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells.

    Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells.
    Boussaid I, Le Goff S, Floquet C, Gautier EF, Raimbault A, Viailly PJ, Al Dulaimi D, Burroni B, Dusanter-Fourt I, Hatin I, Mayeux P, Cosson B, Fontenay M., Free PMC Article

    07/10/2021
    L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients.

    L-leucine increases translation of RPS14 and LARP1 in erythroblasts from del(5q) myelodysplastic syndrome patients.
    Bello E, Kerry J, Singh S, Yip BH, Kušec R, Killick S, Raynaud S, Boultwood J, Pellagatti A., Free PMC Article

    10/12/2019
    Partial silencing of RPS14 inhibits the proliferation of SKM-1, an acute myeloid leukemia cell line, and RPS14 negatively regulates p53 activation in SKM-1 cells.

    Ribosomal protein S14 silencing inhibits growth of acute myeloid leukemia transformed from myelodysplastic syndromes via activating p53.
    Wang L, Luo J, Nian Q, Xiao Q, Yang Z, Liu L.

    01/10/2015
    RPS14 stabilized and activated p53 by inhibiting HDM2-mediated p53 polyubiquitination and degradation

    hCINAP is a novel regulator of ribosomal protein-HDM2-p53 pathway by controlling NEDDylation of ribosomal protein S14.
    Zhang J, Bai D, Ma X, Guan J, Zheng X.

    03/15/2014
    Patients with nonclassical Diamond Blackfan anemia and other hypoproliferative anemias may have somatically acquired 5q deletions with RPS14 haploinsufficiency

    Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome.
    Vlachos A, Farrar JE, Atsidaftos E, Muir E, Narla A, Markello TC, Singh SA, Landowski M, Gazda HT, Blanc L, Liu JM, Ellis SR, Arceci RJ, Ebert BL, Bodine DM, Lipton JM., Free PMC Article

    11/23/2013
    Data indicate that RPS14 negates c-Myc functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA.

    Ribosomal protein S14 negatively regulates c-Myc activity.
    Zhou X, Hao Q, Liao JM, Liao P, Lu H., Free PMC Article

    11/16/2013
    lower RPS14 predicts prolonged survival and possible response to lenalidomide in lower risk MDS patients.

    Low RPS14 expression in MDS without 5q - aberration confers higher apoptosis rate of nucleated erythrocytes and predicts prolonged survival and possible response to lenalidomide in lower risk non-5q- patients.
    Wu L, Li X, Xu F, Zhang Z, Chang C, He Q.

    07/13/2013
    RPS14 and RPS19 have distinct roles in regulating the MDM2-p53 feedback loop in response to ribosomal stress

    Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress.
    Zhou X, Hao Q, Liao J, Zhang Q, Lu H., Free PMC Article

    03/16/2013
    Loss of RPS14 is associated with 5q-syndrome.

    Effects of L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts.
    Yip BH, Pellagatti A, Vuppusetty C, Giagounidis A, Germing U, Lamikanra AA, Roberts DJ, Fernandez-Mercado M, McDonald EJ, Killick S, Wainscoat JS, Boultwood J.

    11/17/2012
    Combined loss of miR-145 and RPS14 cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome.

    Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome.
    Kumar MS, Narla A, Nonami A, Mullally A, Dimitrova N, Ball B, McAuley JR, Poveromo L, Kutok JL, Galili N, Raza A, Attar E, Gilliland DG, Jacks T, Ebert BL., Free PMC Article

    01/7/2012
    Myelodysplactic syndrome patients with an intermediate-1 risk score and low RPS14 expression have a superior median overall survival compared to patients with high RPS14 expression.

    Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival.
    Czibere A, Bruns I, Junge B, Singh R, Kobbe G, Haas R, Germing U., Free PMC Article

    08/6/2011
    p53 accumulates selectively in the erythroid lineage in primary human hematopoietic progenitor cells after expression of shRNAs targeting RPS14, the ribosomal protein gene deleted in the 5q-syndrome, or RPS19.

    Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.
    Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, Megerdichian C, Wilson FH, Currie T, Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL., Free PMC Article

    05/14/2011
    observations in the patient setting support the importance of RPS14 in the pathogenesis of MDS with del(5q)

    Changes in RPS14 expression levels during lenalidomide treatment in Low- and Intermediate-1-risk myelodysplastic syndromes with chromosome 5q deletion.
    Oliva EN, Cuzzola M, Nobile F, Ronco F, D'Errigo MG, Laganà C, Morabito F, Galimberti S, Cortelezzi A, Aloe Spiriti MA, Specchia G, Poloni A, Breccia M, Ghio R, Finelli C, Iacopino P, Alimena G, Latagliata R.

    10/4/2010
    Studied the methylation status of the RPS14 gene in 5q deletion (5q21.3q33.1) in 24 patients. In all, 21 of the 37 patients (57%) had copy number alterations. No homozygous losses or amplifications were observed.

    High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes.
    Borze I, Juvonen E, Ninomiya S, Jee KJ, Elonen E, Knuutila S.

    05/3/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ.

    Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations.
    Quarello P, Garelli E, Carando A, Brusco A, Calabrese R, Dufour C, Longoni D, Misuraca A, Vinti L, Aspesi A, Biondini L, Loreni F, Dianzani I, Ramenghi U.

    12/2/2009
    low expression of RPS14 is not due to promoter hypermethylation, further supporting the haploinsufficiency model suggested by Ebert et al4 for the 5q- syndrome

    Lack of RPS14 promoter aberrant methylation supports the haploinsufficiency model for the 5q- syndrome.
    Valencia A, Cervera J, Such E, Sanz MA, Sanz GF.

    01/21/2010
    results indicate that the 5q- syndrome is caused by a defect in RPS14 ribosomal protein function

    Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.
    Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, Raza A, Root DE, Attar E, Ellis SR, Golub TR., Free PMC Article

    01/21/2010
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