| PPP1R14B-mediated phosphorylation enhances protein stability of RPS6KA1 to promote hepatocellular carcinoma tumorigenesis. | PPP1R14B-mediated phosphorylation enhances protein stability of RPS6KA1 to promote hepatocellular carcinoma tumorigenesis.
Zhou N, Guo C, Du J, Xu Q, Li J, Huang D, Zheng X, Tu L. | 10/25/2024 |
| RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin. | RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin.
Guo X, Huang G, Qiu D, He H, Niu X, Guo Z, Ye Y., Free PMC Article | 10/5/2024 |
| The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia. | The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax/azacitidine in acute myeloid leukemia.
Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank MF, Heid D, Waclawiczek A, Corbacioglu A, Göllner S, Lotze M, Vierbaum L, Renders S, Krijgsveld J, Raffel S, Sauer T, Trumpp A, Pabst C, Müller-Tidow C, Janssen M., Free PMC Article | 08/7/2023 |
| Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses. | Comprehensive analysis of the RSK gene family in acute myeloid leukemia determines a prognostic signature for the prediction of clinical prognosis and treatment responses.
Wu S, Jin J, Huang J, Chen G, Chen Y. | 07/25/2023 |
| Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma. | Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma.
Chen L, Wang W, Leng Q, Cong L, Wu C, Yang X. | 08/13/2022 |
| Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer. | Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.
Cheng DK, Oni TE, Thalappillil JS, Park Y, Ting HC, Alagesan B, Prasad NV, Addison K, Rivera KD, Pappin DJ, Van Aelst L, Tuveson DA., Free PMC Article | 12/4/2021 |
| The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line. | The Preeclamptic Environment Promotes the Activation of Transcription Factor Kappa B by P53/RSK1 Complex in a HTR8/SVneo Trophoblastic Cell Line.
Sakowicz A, Bralewska M, Pietrucha T, Figueras F, Habrowska-Górczyńska DE, Piastowska-Ciesielska AW, Gach A, Sakowicz B, Rybak-Krzyszkowska M, Huras H, Grzesiak M, Biesiada L., Free PMC Article | 10/30/2021 |
| MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases. | MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Sok P, Gógl G, Kumar GS, Alexa A, Singh N, Kirsch K, Sebő A, Drahos L, Gáspári Z, Peti W, Reményi A., Free PMC Article | 08/14/2021 |
| Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk. | Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk.
Shareefi G, Turkistani AN, Alsayyah A, Kussaibi H, Abdel Hadi M, Alkharsah KR., Free PMC Article | 04/13/2021 |
| Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal. | Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal.
Takata T, Araki S, Tsuchiya Y, Watanabe Y., Free PMC Article | 03/6/2021 |
| Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration. | Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration.
M Hajj GN, da Silva FF, de Bellis B, Lupinacci FCS, Bellato HM, Cruz JR, Segundo CNC, Faquini IV, Torres LC, Sanematsu PI, Begnami MD, Martins VR, Roffé M., Free PMC Article | 02/6/2021 |
| Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion. | Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.
Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP., Free PMC Article | 10/24/2020 |
| combination antiretroviral therapy increased monocyte/macrophage sensitivity to reactive oxygen species- in HIV(+) individuals by suppressing NRF2-ARE activity via p90RSK-mediated ERK5 S496 phosphorylation, which coordinately elicited senescent phenotypes and proinflammatory responses | Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals.
Singh MV, Kotla S, Le NT, Ae Ko K, Heo KS, Wang Y, Fujii Y, Thi Vu H, McBeath E, Thomas TN, Jin Gi Y, Tao Y, Medina JL, Taunton J, Carson N, Dogra V, Doyley MM, Tyrell A, Lu W, Qiu X, Stirpe NE, Gates KJ, Hurley C, Fujiwara K, Maggirwar SB, Schifitto G, Abe JI., Free PMC Article | 12/7/2019 |
| FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. | Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.
Kapadia B, Nanaji NM, Bhalla K, Bhandary B, Lapidus R, Beheshti A, Evens AM, Gartenhaus RB., Free PMC Article | 11/24/2018 |
| Polymorphism in p90Rsk gene is associated with Fetal Alcohol Spectrum Disorders. | L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis.
Dou X, Menkari C, Mitsuyama R, Foroud T, Wetherill L, Hammond P, Suttie M, Chen X, Chen SY, Charness ME, Collaborative Initiative on Fetal Alcohol Spectrum Disorders., Free PMC Article | 11/17/2018 |
| The results suggested a possible link between tRNALeu overexpression and RSK1/MSK2 activation and ErbB2/ErbB3 signaling, especially in breast cancer. | Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signaling for cell proliferation.
Kwon NH, Lee MR, Kong J, Park SK, Hwang BJ, Kim BG, Lee ES, Moon HG, Kim S., Free PMC Article | 11/3/2018 |
| Phosphorylation at Ser732 affects ribosomal S6 kinase 1 (RSK1) C-terminal tail (CTT) binding. | Dynamic control of RSK complexes by phosphoswitch-based regulation.
Gógl G, Biri-Kovács B, Póti ÁL, Vadászi H, Szeder B, Bodor A, Schlosser G, Ács A, Turiák L, Buday L, Alexa A, Nyitray L, Reményi A. | 11/3/2018 |
| RSK1 induced self-ubiquitination and destabilisation of UBE2R1 by phosphorylation but did not phosphorylate FBXO15. | RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1.
Katayama K, Fujiwara C, Noguchi K, Sugimoto Y, Katayama K, Fujiwara C, Noguchi K, Sugimoto Y., Free PMC Articles: PMC5081560, PMC5081560 | 05/19/2018 |
| Genetic or pharmacologic inhibition of p90RSK in ganetespib-resistant cells restored sensitivity to ganetespib, whereas p90RSK overexpression induced ganetespib resistance in naive cells, validating p90RSK as a mediator of resistance and a novel therapeutic target | Acquired Resistance to the Hsp90 Inhibitor, Ganetespib, in KRAS-Mutant NSCLC Is Mediated via Reactivation of the ERK-p90RSK-mTOR Signaling Network.
Chatterjee S, Huang EH, Christie I, Kurland BF, Burns TF., Free PMC Article | 02/24/2018 |
| These results suggest that RSK1 protects P-gp against ubiquitination by reducing UBE2R1 stability. | RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1.
Katayama K, Fujiwara C, Noguchi K, Sugimoto Y, Katayama K, Fujiwara C, Noguchi K, Sugimoto Y., Free PMC Articles: PMC5081560, PMC5081560 | 02/16/2018 |
| Data suggest that UBR5 down-regulates levels of TRAF3, a key component of Toll-like receptor signaling, via the miRNA pathway; p90RSK is an upstream regulator of UBR5; p90RSK phosphorylates UBR5 as required for translational repression of TRAF3 mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 = TNF receptor-associated factor 3; p90RSK = 90 kDa ribosomal protein S6 kinase) | The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3.
Cho JH, Kim SA, Seo YS, Park SG, Park BC, Kim JH, Kim S., Free PMC Article | 08/5/2017 |
| Data indicate that BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of microRNA miR-125b. | Identification of miR-125b targets involved in acute promyelocytic leukemia cell proliferation.
Zhang Y, Zeng C, Lu S, Qin T, Yang L, Chen S, Chen J, Li Y. | 06/24/2017 |
| VEGF-A driven Mdm2 phosphorylation on Ser166 is dependent on the ERK1/2/p90RSK signaling pathway in primary human endothelial cells. | The Vascular Endothelial Growth Factor-A phosphorylates Murine Double Minute-2 on its Serine 166 via the Extracellular Signal-Regulated Kinase 1/2 and p90 Ribosomal S6 Kinase in primary human endothelial cells.
Aiken J, Birot O. | 06/3/2017 |
| The p90RSK has an essential role in promoting tumor growth and proliferation in non-small cell lung cancer (NSCLC). BID may serve as an alternative cancer treatment in NSCLC. | Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin.
Abdulrahman N, Jaballah M, Poomakkoth N, Riaz S, Abdelaziz S, Issa A, Mraiche F. | 02/4/2017 |
| RSK1 binds to EBP50 at its first PDZ domain, and mitogen activated RSK1 phosphorylates EBP50 at T156, an event that is crucial for its nuclear localization | Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation.
Lim HC, Jou TS., Free PMC Article | 12/31/2016 |