| RPN2 in cancer: An overview. | RPN2 in cancer: An overview.
Han Z, Wang Y, Han L, Yang C. | 02/25/2023 |
| The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2. | The N(6)-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.
Li B, Zhao R, Qiu W, Pan Z, Zhao S, Qi Y, Qiu J, Zhang S, Guo Q, Fan Y, Xu H, Li M, Li G, Xue H., Free PMC Article | 10/8/2022 |
| Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis. | Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis.
Zhu J, Xie B, Huang G, Li Y, Liu Z. | 07/9/2022 |
| Ribophorin II promotes the epithelial-mesenchymal transition and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol-3-Kinase/Protein Kinase B activation. | Ribophorin II promotes the epithelial-mesenchymal transition and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol-3-Kinase/Protein Kinase B activation.
Zhou J, Zhang J, Zhang W, Ke Z, Lv Y, Zhang B, Liao Z., Free PMC Article | 04/16/2022 |
| Epigenetically-regulated RPN2 gene influences lymphocyte activation and is involved in pathogenesis of rheumatoid arthritis. | Epigenetically-regulated RPN2 gene influences lymphocyte activation and is involved in pathogenesis of rheumatoid arthritis.
He P, Deng FY, Wang BH, Wu LF, Zhou X, Lei SF. | 01/8/2022 |
| Overexpression of ribophorin II is required for viability of nasopharyngeal cancer cells by regulating JAK1/STAT3 activation. | Overexpression of ribophorin II is required for viability of nasopharyngeal cancer cells by regulating JAK1/STAT3 activation.
Wang B, Liu W, Jiang X, Li J, Hu X, Li L, Gu Q. | 01/1/2022 |
| Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction. | Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction.
Li C, Ran H, Song S, Liu W, Zou W, Jiang B, Zhao H, Shao B., Free PMC Article | 08/14/2021 |
| MicroRNA422a functions as a tumor suppressor in glioma by regulating the Wnt/betacatenin signaling pathway via RPN2. | MicroRNA‑422a functions as a tumor suppressor in glioma by regulating the Wnt/β‑catenin signaling pathway via RPN2.
Sun J, Chen Z, Xiong J, Wang Q, Tang F, Zhang X, Mo L, Wang C, Fan W, Wang J., Free PMC Article | 07/10/2021 |
| An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure. | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Lu X, Ebelle DL, Matsuo H, Walters KJ., Free PMC Article | 06/12/2021 |
| RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/beta-catenin signaling pathway. | RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/β-catenin signaling pathway.
Sun J, Ma Q, Li B, Wang C, Mo L, Zhang X, Tang F, Wang Q, Yan X, Yao X, Wu Q, Shu C, Xiong J, Fan W, Wang J., Free PMC Article | 04/13/2021 |
| Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression. | Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression.
Ren J, Wang Y, Wang L, Guo X, Guo X., Free PMC Article | 02/20/2021 |
| Overexpression of RPN2 promotes osteogenic differentiation of hBMSCs through the JAK/STAT3 pathway. | Overexpression of RPN2 promotes osteogenic differentiation of hBMSCs through the JAK/STAT3 pathway.
Ni L, Yu J, Gui X, Lu Z, Wang X, Guo H, Zhou Y., Free PMC Article | 01/9/2021 |
| Findings indicate increased oligosaccharyltransferase complex subunit (non-catalytic) ribophorin-2 (RPN2) expression in esophageal cancer tissues and cell lines. | Ribophorin II promotes cell proliferation, migration, and invasion in esophageal cancer cells in vitro and in vivo.
Li Y, Huang C, Bai Q, Yu J., Free PMC Article | 07/11/2020 |
| Knockdown of circNFIX inhibits progression of glioma in vitro and in vivo by increasing miR-378e and decreasing RPN2, providing a novel mechanism for understanding the pathogenesis of glioma. | CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.
Ding C, Wu Z, You H, Ge H, Zheng S, Lin Y, Wu X, Lin Z, Kang D., Free PMC Article | 05/16/2020 |
| reveals specific interactions with positively charged side chains in RPN13 that explain how phosphorylation increases binding affinity without inducing conformational change | Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13.
Hemmis CW, Heard SC, Hill CP., Free PMC Article | 03/7/2020 |
| RPN2 potentiated P-gp- and ABCG2-mediated MDR via activating MEK/ERK pathway in GC | Ribophorin II potentiates P-glycoprotein- and ABCG2-mediated multidrug resistance via activating ERK pathway in gastric cancer.
Zhang H, Jiang H, Zhang H, Liu J, Hu X, Chen L. | 06/29/2019 |
| Rpn13-Rpn2 complex structural analysis shows that RA190 targets hRpn13 and Uch37 through parallel mechanisms and at proteasomes, RA190-inactivated Uch37 cannot disassemble hRpn13-bound ubiquitin chains | Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Lu X, Nowicka U, Sridharan V, Liu F, Randles L, Hymel D, Dyba M, Tarasov SG, Tarasova NI, Zhao XZ, Hamazaki J, Murata S, Burke TR Jr, Walters KJ., Free PMC Article | 12/22/2018 |
| These findings indicated a novel pathway of tumor-promoting activity by RPN2 in colorectal cancer (CRC), with significant implications for unraveling the tumorigenesis of CRC. | Downregulation of RPN2 induces apoptosis and inhibits migration and invasion in colon carcinoma.
Bi C, Jiang B., Free PMC Article | 09/29/2018 |
| RPN2 expression correlates with gastric adenocarcinoma cell invasion and shows promise as a new prognostic factor in human gastric adenocarcinoma | Expression of ribophorine II is a promising prognostic factor in human gastric adenocarcinoma.
Fujimoto D, Goi T, Hirono Y. | 04/29/2017 |
| Data suggest that RPN2 is involved in the regulation of lethal cancer phenotypes and represents a promising new target for RNAi-based medicine against non-small cell lung cancer. | Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer.
Fujita Y, Yagishita S, Takeshita F, Yamamoto Y, Kuwano K, Ochiya T., Free PMC Article | 04/2/2016 |
| Of the total, the deregulation of several genes (CDK1, CDK2, CDK4, MCM2, MCM3, MCM4, EIF3a and RPN2) were potentially associated with disease development and progression. | Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.
Lian M, Fang J, Han D, Ma H, Feng L, Wang R, Yang F., Free PMC Article | 02/28/2015 |
| these results indicated that high glycosylation of CD63 by RPN2 is implicated in clinical outcomes in breast cancer patients | RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy.
Tominaga N, Hagiwara K, Kosaka N, Honma K, Nakagama H, Ochiya T., Free PMC Article | 12/20/2014 |
| Furthermore, our study reveals that high expression of RPN2 and concomitant accumulation of mtp53 were associated with cancer tissues in a small cohort of metastatic breast cancer patients. | Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β.
Takahashi RU, Takeshita F, Honma K, Ono M, Kato K, Ochiya T., Free PMC Article | 02/15/2014 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Rpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding. | Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.
Chen X, Lee BH, Finley D, Walters KJ., Free PMC Article | 06/14/2010 |