DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer. | DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer. Hu X, Li F, Zhou Y, Gan H, Wang T, Li L, Long H, Li B, Pang P., Free PMC Article | 01/11/2023 |
Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway. | Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway. Zhang H, Liu J, Dang Q, Wang X, Chen J, Lin X, Yang N, Du J, Shi H, Liu Y, Han J., Free PMC Article | 11/26/2022 |
Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy. | Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy. Ma X, Li Y, Zhao B., Free PMC Article | 05/7/2022 |
Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. | Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly. Matsumori H, Watanabe K, Tachiwana H, Fujita T, Ito Y, Tokunaga M, Sakata-Sogawa K, Osakada H, Haraguchi T, Awazu A, Ochiai H, Sakata Y, Ochiai K, Toki T, Ito E, Goldberg IG, Tokunaga K, Nakao M, Saitoh N., Free PMC Article | 04/23/2022 |
Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. | Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency. Fukui Y, Hayano S, Kawanabe N, Wang Z, Shimada A, Saito MK, Asaka I, Kamioka H. | 02/19/2022 |
Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis. | Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis. Hassan FM, Alsultan A, Alzehrani F, Albuali W, Bubshait D, Abass E, Elbasheer M, Alkhanbashi A., Free PMC Article | 01/22/2022 |
Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. | Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients. Hassan FM, Alsultan AA, Alzahrani F, Albuali WH, Bubshait DK, Abass EM, Elbasheer MA, Alkhanbashi AA., Free PMC Article | 09/11/2021 |
The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate. | The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate. Lin Y, Song T, Ronde EM, Ma G, Cui H, Xu M., Free PMC Article | 06/5/2021 |
Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint. | Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint. Oršolić I, Bursać S, Jurada D, Drmić Hofman I, Dembić Z, Bartek J, Mihalek I, Volarević S. | 11/28/2020 |
Our results also show extra-ribosomal uL18/L5 is formed during 60S assembly, not during degradation of mature cytoplasmic 60S subunits. | Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5. Rahman N, Shamsuzzaman M, Lindahl L., Free PMC Article | 04/4/2020 |
Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects. This is the first study to show differences between Diamond-Blackfan anemia (DBA) genetic groups with regards to treatment. | Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia. Arbiv OA, Cuvelier G, Klaassen RJ, Fernandez CV, Robitaille N, Steele M, Breakey V, Abish S, Wu J, Sinha R, Silva M, Goodyear L, Jardine L, Lipton JH, Corriveau-Bourque C, Brossard J, Michon B, Ghemlas I, Waespe N, Zlateska B, Sung L, Cada M, Dror Y. | 08/3/2019 |
RPL5 remains an interesting candidate in multiple myelom(MM )because it is deleted in 20-40% of MM cases | Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma. Hofman IJF, Patchett S, van Duin M, Geerdens E, Verbeeck J, Michaux L, Delforge M, Sonneveld P, Johnson AW, De Keersmaecker K., Free PMC Article | 10/27/2018 |
Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations | Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations. Errichiello E, Vetro A, Mina T, Wischmeijer A, Berrino E, Carella M, Romagnoli M, Sacchini P, Venesio T, Zecca M, Zuffardi O., Free PMC Article | 08/18/2018 |
Low RPL5 expression is associated with cancer. | The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types. Fancello L, Kampen KR, Hofman IJ, Verbeeck J, De Keersmaecker K., Free PMC Article | 10/14/2017 |
Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. | Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition. Zhou X, Hao Q, Zhang Q, Liao JM, Ke JW, Liao P, Cao B, Lu H., Free PMC Article | 12/26/2015 |
RPL5 mutation is associated with Diamond Blackfan Anemia. | Clinical phenotype and genetic analysis of RPS19, RPL5, and RPL11 genes in Greek patients with Diamond Blackfan Anemia. Delaporta P, Sofocleous C, Stiakaki E, Polychronopoulou S, Economou M, Kossiva L, Kostaridou S, Kattamis A. | 02/7/2015 |
Findings uncover a mechanism by which RPL5 and RPL11 can co-operatively suppress c-Myc expression, allowing a tightly controlled ribosome biogenesis in cells. | Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex. Liao JM, Zhou X, Gatignol A, Lu H., Free PMC Article | 12/20/2014 |
Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation. | Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Teng T, Mercer CA, Hexley P, Thomas G, Fumagalli S., Free PMC Article | 01/11/2014 |
High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia. | High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay. Quarello P, Garelli E, Brusco A, Carando A, Mancini C, Pappi P, Vinti L, Svahn J, Dianzani I, Ramenghi U., Free PMC Article | 12/14/2013 |
Oncogenic splicing factor SRSF1 stabilizes the tumor suppressor protein p53 via RPL5, inducing cell senescence. | Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence. Fregoso OI, Das S, Akerman M, Krainer AR., Free PMC Article | 06/15/2013 |
Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias. | Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia. De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J., Free PMC Article | 03/30/2013 |
disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress | Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Bursać S, Brdovčak MC, Pfannkuchen M, Orsolić I, Golomb L, Zhu Y, Katz C, Daftuar L, Grabušić K, Vukelić I, Filić V, Oren M, Prives C, Volarevic S., Free PMC Article | 03/2/2013 |
Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion. | Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia. Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I. | 05/26/2012 |
Data show that all patients with RPS19 and RPL5 mutations had physical abnormalities. | Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MJ, Sugita K, Ito E., Free PMC Article | 03/12/2011 |
An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed. | Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. Alcina A, Fernández O, Gonzalez JR, Catalá-Rabasa A, Fedetz M, Ndagire D, Leyva L, Guerrero M, Arnal C, Delgado C, Lucas M, Izquierdo G, Matesanz F., Free PMC Article | 09/20/2010 |