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    RPL5 ribosomal protein L5 [ Homo sapiens (human) ]

    Gene ID: 6125, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

    DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.
    Hu X, Li F, Zhou Y, Gan H, Wang T, Li L, Long H, Li B, Pang P., Free PMC Article

    01/11/2023
    Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.

    Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway.
    Zhang H, Liu J, Dang Q, Wang X, Chen J, Lin X, Yang N, Du J, Shi H, Liu Y, Han J., Free PMC Article

    11/26/2022
    Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy.

    Ribosomal protein L5 (RPL5)/ E2F transcription factor 1 (E2F1) signaling suppresses breast cancer progression via regulating endoplasmic reticulum stress and autophagy.
    Ma X, Li Y, Zhao B., Free PMC Article

    05/7/2022
    Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.

    Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.
    Matsumori H, Watanabe K, Tachiwana H, Fujita T, Ito Y, Tokunaga M, Sakata-Sogawa K, Osakada H, Haraguchi T, Awazu A, Ochiai H, Sakata Y, Ochiai K, Toki T, Ito E, Goldberg IG, Tokunaga K, Nakao M, Saitoh N., Free PMC Article

    04/23/2022
    Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency.

    Investigation of the molecular causes underlying physical abnormalities in Diamond-Blackfan anemia patients with RPL5 haploinsufficiency.
    Fukui Y, Hayano S, Kawanabe N, Wang Z, Shimada A, Saito MK, Asaka I, Kamioka H.

    02/19/2022
    Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.

    Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis.
    Hassan FM, Alsultan A, Alzehrani F, Albuali W, Bubshait D, Abass E, Elbasheer M, Alkhanbashi A., Free PMC Article

    01/22/2022
    Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients.

    Identification of RPL5 gene variants and the risk of hepatic vein thrombosis in Saudi patients.
    Hassan FM, Alsultan AA, Alzahrani F, Albuali WH, Bubshait DK, Abass EM, Elbasheer MA, Alkhanbashi AA., Free PMC Article

    09/11/2021
    The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate.

    The important role of MDM2, RPL5, and TP53 in mycophenolic acid-induced cleft lip and palate.
    Lin Y, Song T, Ronde EM, Ma G, Cui H, Xu M., Free PMC Article

    06/5/2021
    Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint.

    Cancer-associated mutations in the ribosomal protein L5 gene dysregulate the HDM2/p53-mediated ribosome biogenesis checkpoint.
    Oršolić I, Bursać S, Jurada D, Drmić Hofman I, Dembić Z, Bartek J, Mihalek I, Volarević S.

    11/28/2020
    Our results also show extra-ribosomal uL18/L5 is formed during 60S assembly, not during degradation of mature cytoplasmic 60S subunits.

    Interaction between the assembly of the ribosomal subunits: Disruption of 40S ribosomal assembly causes accumulation of extra-ribosomal 60S ribosomal protein uL18/L5.
    Rahman N, Shamsuzzaman M, Lindahl L., Free PMC Article

    04/4/2020
    Patients with RPS19 mutations had the fewest number of defects, while patients with RPL5 had the greatest number of birth defects. This is the first study to show differences between Diamond-Blackfan anemia (DBA) genetic groups with regards to treatment.

    Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia.
    Arbiv OA, Cuvelier G, Klaassen RJ, Fernandez CV, Robitaille N, Steele M, Breakey V, Abish S, Wu J, Sinha R, Silva M, Goodyear L, Jardine L, Lipton JH, Corriveau-Bourque C, Brossard J, Michon B, Ghemlas I, Waespe N, Zlateska B, Sung L, Cada M, Dror Y.

    08/3/2019
    RPL5 remains an interesting candidate in multiple myelom(MM )because it is deleted in 20-40% of MM cases

    Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma.
    Hofman IJF, Patchett S, van Duin M, Geerdens E, Verbeeck J, Michaux L, Delforge M, Sonneveld P, Johnson AW, De Keersmaecker K., Free PMC Article

    10/27/2018
    Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations

    Whole exome sequencing in the differential diagnosis of Diamond-Blackfan anemia: Clinical and molecular study of three patients with novel RPL5 and mosaic RPS19 mutations.
    Errichiello E, Vetro A, Mina T, Wischmeijer A, Berrino E, Carella M, Romagnoli M, Sacchini P, Venesio T, Zecca M, Zuffardi O., Free PMC Article

    08/18/2018
    Low RPL5 expression is associated with cancer.

    The ribosomal protein gene RPL5 is a haploinsufficient tumor suppressor in multiple cancer types.
    Fancello L, Kampen KR, Hofman IJ, Verbeeck J, De Keersmaecker K., Free PMC Article

    10/14/2017
    Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.

    Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.
    Zhou X, Hao Q, Zhang Q, Liao JM, Ke JW, Liao P, Cao B, Lu H., Free PMC Article

    12/26/2015
    RPL5 mutation is associated with Diamond Blackfan Anemia.

    Clinical phenotype and genetic analysis of RPS19, RPL5, and RPL11 genes in Greek patients with Diamond Blackfan Anemia.
    Delaporta P, Sofocleous C, Stiakaki E, Polychronopoulou S, Economou M, Kossiva L, Kostaridou S, Kattamis A.

    02/7/2015
    Findings uncover a mechanism by which RPL5 and RPL11 can co-operatively suppress c-Myc expression, allowing a tightly controlled ribosome biogenesis in cells.

    Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.
    Liao JM, Zhou X, Gatignol A, Lu H., Free PMC Article

    12/20/2014
    Unlike other tumor suppressors, RPL5 and RPL11 play essential roles in normal cell proliferation.

    Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.
    Teng T, Mercer CA, Hexley P, Thomas G, Fumagalli S., Free PMC Article

    01/11/2014
    High frequency of RPL5 gene deletion is associated with Italian Diamond-Blackfan anemia.

    High frequency of ribosomal protein gene deletions in Italian Diamond-Blackfan anemia patients detected by multiplex ligation-dependent probe amplification assay.
    Quarello P, Garelli E, Brusco A, Carando A, Mancini C, Pappi P, Vinti L, Svahn J, Dianzani I, Ramenghi U., Free PMC Article

    12/14/2013
    Oncogenic splicing factor SRSF1 stabilizes the tumor suppressor protein p53 via RPL5, inducing cell senescence.

    Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.
    Fregoso OI, Das S, Akerman M, Krainer AR., Free PMC Article

    06/15/2013
    Mutations affect the ribosomal proteins RPL5 and RPL10 in 12 of 122 (9.8%) pediatric T-cell acute lymphoblastic leukemias.

    Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
    De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J., Free PMC Article

    03/30/2013
    disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53 activation by ribosomal biogenesis stress

    Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress.
    Bursać S, Brdovčak MC, Pfannkuchen M, Orsolić I, Golomb L, Zhu Y, Katz C, Daftuar L, Grabušić K, Vukelić I, Filić V, Oren M, Prives C, Volarevic S., Free PMC Article

    03/2/2013
    Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion.

    Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.
    Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I.

    05/26/2012
    Data show that all patients with RPS19 and RPL5 mutations had physical abnormalities.

    Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia.
    Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MJ, Sugita K, Ito E., Free PMC Article

    03/12/2011
    An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed.

    Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis.
    Alcina A, Fernández O, Gonzalez JR, Catalá-Rabasa A, Fedetz M, Ndagire D, Leyva L, Guerrero M, Arnal C, Delgado C, Lucas M, Izquierdo G, Matesanz F., Free PMC Article

    09/20/2010
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